[Grußwort zur Eröffnung der Tagung: 6th Frankfurt Scientific Symposium, GNARP und wie sie die Welt sieht: Aussichten transatlantischer Partnerschaft im digitalen Zeitalter: 5.10.2006 - 7.10.2006]

... This year's Scientific Symposium of the University Library is already number six in the row. It was again prepared and organised like some of the previous conferences together with our North American partners. This means that a continuous specialists’ discussion and a professional partnership have been already installed. All librarians and information managers are invited to learn more about the results of this co­operation every year when it's time for the next Symposium during Frankfurt Book Fair. ..

A Complexity Preserving Transformation from Jinja Bytecode to Rewrite Systems

We revisit known transformations from Jinja bytecode to rewrite systems from the viewpoint of runtime complexity. Suitably generalising the constructions proposed in the literature, we define an alternative representation of Jinja bytecode (JBC) executions as "computation graphs" from which we obtain a novel representation of JBC executions as "constrained rewrite systems". We prove non-termination and complexity preservation of the transformation. We restrict to well-formed JBC programs that only make use of non-recursive methods and expect tree-shaped objects as input. Our approach allows for simplified correctness proofs and provides a framework for the combination of the computation graph method with standard techniques from static program analysis like for example "reachability analysis".Comment: 36 page

The arrival of the frequent: how bias in genotype-phenotype maps can steer populations to local optima

Genotype-phenotype (GP) maps specify how the random mutations that change genotypes generate variation by altering phenotypes, which, in turn, can trigger selection. Many GP maps share the following general properties: 1) The number of genotypes $N_G$ is much larger than the number of selectable phenotypes; 2) Neutral exploration changes the variation that is accessible to the population; 3) The distribution of phenotype frequencies $F_p=N_p/N_G$, with $N_p$ the number of genotypes mapping onto phenotype $p$, is highly biased: the majority of genotypes map to only a small minority of the phenotypes. Here we explore how these properties affect the evolutionary dynamics of haploid Wright-Fisher models that are coupled to a simplified and general random GP map or to a more complex RNA sequence to secondary structure map. For both maps the probability of a mutation leading to a phenotype $p$ scales to first order as $F_p$, although for the RNA map there are further correlations as well. By using mean-field theory, supported by computer simulations, we show that the discovery time $T_p$ of a phenotype $p$ similarly scales to first order as $1/F_p$ for a wide range of population sizes and mutation rates in both the monomorphic and polymorphic regimes. These differences in the rate at which variation arises can vary over many orders of magnitude. Phenotypic variation with a larger $F_p$ is therefore be much more likely to arise than variation with a small $F_p$. We show, using the RNA model, that frequent phenotypes (with larger $F_p$) can fix in a population even when alternative, but less frequent, phenotypes with much higher fitness are potentially accessible. In other words, if the fittest never `arrive' on the timescales of evolutionary change, then they can't fix. We call this highly non-ergodic effect the `arrival of the frequent'.Comment: full paper plus supplementary material

Arteriogenesis versus angiogenesis: similarities and differences

Cardiovascular diseases account for more than half of total mortality before the age of 75 in industrialized countries. To develop therapies promoting the compensatory growth of blood vessels could be superior to palliative surgical surgical interventions. Therefore, much effort has been put into investigating underlying mechanisms. Depending on the initial trigger, growth of blood vessels in adult organisms proceeds via two major processes, angiogenesis and arteriogenesis. While angiogenesis is induced by hypoxia and results in new capillaries, arteriogenesis is induced by physical forces, most importantly fluid shear stress. Consequently, chronically elevated fluid shear stress was found to be the strongest trigger under experimental conditions. Arteriogenesis describes the remodelling of pre-existing arterio-arteriolar anastomoses to completely developed and functional arteries. In both growth processes, enlargement of vascular wall structures was proposed to be covered by proliferation of existing wall cells. Recently, increasing evidence emerges, implicating a pivotal role for circulating cells, above all blood monocytes, in vascular growth processes. Since it has been shown that monocytes/macrophage release a cocktail of chemokines, growth factors and proteases involved in vascular growth, their contribution seems to be of a paracrine fashion. A similar role is currently discussed for various populations of bone-marrow derived stem cells and endothelial progenitors. In contrast, the initial hypothesis that these cells -after undergoing a (trans-)differentiation- contribute by a structural integration into the growing vessel wall, is increasingly challenged

Book Review: Body by Weimar: Athletes, Gender, and German Modernity (By Erik N. Jensen. New York, NY: Oxford University Press. 2010. S. 184)

For a long time, the history of sports has tended to limit its interest to sport’s inherent structures and developments. It has failed, and often continues to fail, to analyse sport in a broader context. In the last few years, however, there have been efforts to examine the significance of sport in relation to social, cultural and political developments. Jensen ties in with these approaches, which, in the case of Weimar history, have started examining boxing, football and other competitive sports in general to explore the culture and society of Germany in the 1920s and early 1930s..