6 research outputs found
Optimization of microwave assisted extraction (MAE) and soxhlet extraction of phenolic compound from licorice root
No full textEpidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies
No full textAmplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in pathogenesis, targeted therapy with EGFR-tyrosine kinase inhibitors (TKIs) or antibodies has only shown limited efficacy in patients. Here we discuss signaling pathways mediated by EGFR/EGFRvIII, current therapeutics, and novel strategies to target EGFR/EGFRvIII-amplified GBM
