A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Alfuzosin hydrochloride transdermal films: evaluation of physicochemical, in vitro human cadaver skin permeation and thermodynamic parameters

Purpose: The main objective of the investigation was to develop a transdermal therapeutic system for alfuzosin hydrochloride and to study the effects of polymeric system and loading dose on the in vitro skin permeation pattern. Materials and methods: Principles of experimental design have been exploited to develop the dosage form. Ratio of ethyl cellulose (EC) and polyvinyl pyrrolidone (PVP) and loading dose were selected as independent variables and their influence on the cumulative amount of alfuzosin hydrochloride permeated per cm2 of human cadaver skin at 24 h (Q24), permeation flux (J) and steady state permeability coefficient (P SS) were studied using experimental design. Various physicochemical parameters of the transdermal films were also evaluated. Activation energy for in vitro transdermal permeation has been estimated. Results: Ratio of EC and PVP was found to be the main influential factor for all the dependent variables studied. Drug loading dose was also found to influence the dependent variables but to a lesser extent. Physicochemical parameters of the prepared films were evaluated and found satisfactory. Activation energy for alfuzosin permeation has also been estimated and reported. Conclusion: The therapeutic system was found to be dermatologically non-irritant and hence, a therapeutically effective amount of alfuzosin hydrochloride can be delivered via a transdermal route

Experimental and Numerical Shortest Route Optimization in Generating a Design Template for a Recreation Area in Kadifekale

As cities grow, their complexity and the complexity of their infrastructure for various applications increase. Especially, transportation design is usually a very cumbersome process in current urban development models, and it is becoming more complex. Traditional approaches are not always sufficient to solve such complex problems, therefore, design disciplines like architecture and urban design need new tools to optimize many parameters related to their design. An alternate way to solve this problem can be via finding shortest routes. In this context, this study aims to evaluate different shortest path algorithms within a methodological approach to urban transportation planning via either experimentation or mathematical modeling. Three methods; namely live slime mold plasmodium, Floyd-Warshall algorithm, and ant colony algorithm are used to design a template for routes within the historical Kadifekale district of Izmir, Turkey. The results from these approaches are compared, contrasted, and discussed in terms of their suitability for use as a guide for route creation. In conclusion, the parameters of an algorithm are significant on suggesting routes, thus the strengths and weaknesses of an algorithm should be carefully considered before application in a design problem