10 research outputs found
Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy
Rosacea is a chronic inflammatory disease with transient and non-transient redness as key characteristics. Brimonidine is a selective α2-adrenergic receptor (AR) agonist approved for persistent facial erythema of rosacea based on significant efficacy and good safety data. The majority of patients treated with brimonidine report a benefit; however, there have been sporadic reports of worsening erythema after the initial response. A group of dermatologists, receptor physiology, and neuroimmunology scientists met to explore potential mechanisms contributing to side effects as well as differences in efficacy. We propose the following could contribute to erythema after application: (1) local inflammation and perivascular inflammatory cells with abnormally functioning ARs may lead to vasodilatation; (2) abnormal saturation and cells expressing different AR subtypes with varying ligand affinity; (3) barrier dysfunction and increased skin concentrations of brimonidine with increased actions at endothelial and presynaptic receptors, resulting in increased vasodilation; and (4) genetic predisposition and receptor polymorphism(s) leading to different smooth muscle responses. Approximately 80% of patients treated with brimonidine experience a significant improvement without erythema worsening as an adverse event. Attention to optimizing skin barrier function, setting patient expectations, and strategies to minimize potential problems may possibly reduce further the number of patients who experience side effects. Funding: Galderma International S.A.S., Paris, France
Double staining for 5-HT2AR (a) and CD3 (b), SERT (c), and CD3 (d) respectively in the papillary dermis of involved skin
<p><b>Copyright information:</b></p><p>Taken from "Neuroimmune mechanisms in patients with atopic dermatitis during chronic stress"</p><p></p><p>Journal of the European Academy of Dermatology and Venereology 2008;22(1):11-18.</p><p>Published online Jan 2008</p><p>PMCID:PMC2229631.</p><p>© 2008 The Authors Journal compilation © 2008 European Academy of Dermatology and Venereology</p> a and c, Texas red; b and d, FITC. Magnification, ×200