The impact of industry group culture on the development of opportunism in cross-sector alliances

Over the last two decades the world economy has dramatically transformed, with strategic alliances and partnerships across industrial and global boundaries becoming an important means to maintaining and regaining competitive positioning. In spite of an increase in partnership activity, alliances continue to face problems fuelled by factors such as partner opportunism, and cultural incompatibility. This paper highlights the emergence of opportunism in alliances arising from cross-sectoral partners’ differences in cultural values and norms. The literature indicates that cultural differences are important factors for understanding the behaviour of managers across sectors

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.

Contraction in the mammalian heart is controlled by the intracellular Ca2+ concentration as it is in all striated muscle, but the heart has an additional signalling system that comes into play to increase heart rate and cardiac output during exercise or stress. β-adrenergic stimulation of heart muscle cells leads to release of cyclic-AMP and the activation of protein kinase A which phosphorylates key proteins in the sarcolemma, sarcoplasmic reticulum and contractile apparatus. Troponin I (TnI) and Myosin Binding Protein C (MyBP-C) are the prime targets in the myofilaments. TnI phosphorylation lowers myofibrillar Ca2+-sensitivity and increases the speed of Ca2+-dissociation and relaxation (lusitropic effect).Recent studies have shown that this relationship between Ca2+-sensitivity and TnI phosphorylation may be unstable. In familial cardiomyopathies, both dilated and hypertrophic (DCM and HCM), a mutation in one of the proteins of the thin filament often results in the loss of the relationship (uncoupling) and blunting of the lusitropic response. For familial dilated cardiomyopathy in thin filament proteins it has been proposed that this uncoupling is causative of the phenotype. Uncoupling has also been found in human heart tissue from patients with hypertrophic obstructive cardiomyopathy as a secondary effect. Recently, it has been found that Ca2+-sensitizing drugs can promote uncoupling, whilst one Ca2+-desensitising drug Epigallocatechin 3-Gallate (EGCG) can reverse uncoupling.We will discuss recent findings about the role of uncoupling in the development of cardiomyopathies and the molecular mechanism of the process

A pressão coronária (às vezes) mente. . .

Comment on: Comparative analysis of fractional flow reserve and instantaneous wave-free ratio: Results of a five-year registry. [Rev Port Cardiol. 2018]info:eu-repo/semantics/publishedVersio

COMPARISON OF KINEMATICS AND ACCURACY OF OVERHAND AMERICAN FOOTBALL THROWING

This study examined elbow angle, wrist velocity and throwing accuracy during American Football throws. Six repetitions of three types of throws: Self-selected pass (SS), Lob pass (L), and a Bullet pass (B); were performed to hit a point scaled target from 10.97 m. Independent variables were frontal plane shoulder angle (more or less than 90º) and throw type; dependent variables were elbow angle in the sagittal plane, wrist velocity at ball release, and accuracy. There were no differences for shoulder angle for any variable; while throw types differed only for wrist speed (highest to lowest B, SS, and L). Significant interactions occurred for all variables. These findings suggest that recommendations for American football throwing technique are complicated by the combination of throw type and shoulder angle; and that with no restrictions subjects will throw with more accuracy

Effects of peer comparisons on low-promotability tasks: Evidence from a university field experiment

Governance—the way rules are set and implemented—in many institutions is sustained through the service of groups of individuals, performing low-promotability tasks. For instance, the success of not-for-profit professional societies, civic organizations, and public universities depends on the willingness of members and employees to serve in governance. Typically service is requested by annual calls to serve. We implement and analyze a field experiment at a large public university using a randomized experimental design, to investigate whether responses to calls to serve are affected by revealing a department's service rankings among its peer departments. We find that revealing a service ranking in the lowest quartile leads to significantly higher response rates than disclosing a median and higher-than-median ranking. Second, beyond informing department heads of their departments’ service rank, directly informing individual faculty members does not have an additional effect on response rates. Third, we show that the treatment effects in the lowest serving quartile are driven by female faculty responses, even though female faculty members were no more likely than their male peers to respond to serve before the experiment. If taking on such tasks is detrimental to promotion, while important for the overall institution, this has implications for the faculty careers of women and men. We discuss potential mechanisms behind the results; formally testing these mechanisms is an area for future research