Expression of matrix metalloproteinase-2 and survivin in endometrioid and nonendometrioid endometrial cancers and clinicopathologic significance

Objective: To determine matrix metalloproteinase-2 and survivin expressions in endometrial cancers, their relation to clinical and histologic parameters and to investigate any difference in the expression of these markers between endometrioid and non-endometrioid cancers

A decentralized structure to reduce and resolve construction disputes in a hybrid blockchain network

Disputes routinely arise in construction projects, and they have major cost and schedule impacts. Therefore, they need to be either prevented effectively by proper contract and payment execution or resolved efficiently with enhanced resolution processes regarding cost, duration, effort, and transparency. However, current practices are inadequate for both effectiveness and efficiency since they mainly depend on centralized authority. This paper is designed in two folds; first, a generic blockchain-based online dispute resolution platform is tested with two litigation cases collected in 1999 and 2009 to show the need for a construction-focused system. Then, a new construction-specific framework, Decentralized Construction Enabling Transparent Resolution (DCENTR), is proposed to address the unique nature of construction projects. Ultimately, it is shown that dispute likelihood can be minimized through reliable contract and payment execution, and if occurred, construction disputes can be resolved with higher transparency and dramatic savings in effort, time, and cost

Evaluation of Susceptibility of Different Pear Hybrid Populations to Fire Blight (Erwinia amylovora)

WOS: 000292056600033Fire blight disease caused by pathogenic bacterium Erwinia amylovora, is the serious disease of pear, and there is not a certain chemical management against this disease except antibiotic-type compounds such as streptomycin. It is very important to improve new fire blight resistant cultivars in case of integrated disease management. With this purpose, different crosses have been made between Pyrus communis varieties that have good fruit characteristics and resistant cultigens. Besides, self and open pollination treatments have been carried out in maternal plants. The disease resistance level of the hybrids obtained from these combinations was determined by artificial inoculations by Erwinia amylovora in greenhouse conditions. A total of 3284 hybrids were inoculated, and 2631 of them survived and were distributed to different susceptibility classes. 19.88% of the inoculated hybrids was killed by Erwinia amylovora. Total distribution of the hybrids to susceptibility classes was as 6.18% in class "A- slightly susceptible", 3.11% in class "B- less susceptible", 8.89% in class "C- mid-susceptible", 20.28% in class "D- susceptible; and 61.54% in class "E- very susceptible". Majority of class "A- slightly susceptible" hybrids were obtained from 'Magness' x 'Ankara' combination. 'Kieffer' a 'Santa Maria', 'Kieffer' open pollination, 'Magness' x Aka; 'Magness' a 'Kieffer', 'Magness' x 'Santa Maria', 'Mustafa Bey' x 'Moonglow' treatments displayed good results with respect to 'A- slightly susceptible" character. It is very important to evaluate these hybrid pear populations through different fruit and tree characteristics in the future.TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TOVAG 106O719]This project was supported by TUBITAK (TOVAG 106O719)

Tumor budding and E-Cadherin expression in endometrial carcinoma: Are they prognostic factors in endometrial cancer?

Objective. To evaluate the prognostic value of tumor budding (TB) in endometrioid (EEC) and non-endometrioid endometrial cancers (NEEC) and to determine its correlation with expression of E-cadherin

Retrospective analysis of follicle loss after laparoscopic excision of endometrioma compared with benign nonendometriotic ovarian cysts.

Objective: To evaluate follicle loss in ovarian tissue after laparoscopic excision by the stripping technique in endometriomas versus benign nonendometriotic ovarian cysts. Methods: Cystectomy samples obtained from 127 ovaries from 104 patients (mean age, 29.05 +/- 05 years; range, 19-40 years) by laparoscopic excision (61 endometriomas and 66 benign nonendometriotic cysts) were evaluated for follicle loss. The samples including normal ovarian tissue were graded on a semiquantitative scale from 0 to 4, where 0 was complete absence of follicles and 4 was the pattern of primary and secondary follicles seen in a normal ovary. The results from endometriomas were compared with those from nonendometriotic cysts. Results: There were no differences in mean tissue thickness, or number of primordial, primary, or secondary follicles between the endometriomas and the nonendometriotic cysts (P>0.05). Ovarian cortex was detected in 92% and 82% of the endometriomas and nonendometriotic samples, respectively, (P=0.081). Semiquantitative scoring of ovarian tissue was significantly higher in endometriomas (1.64 +/- 1.35 versus 1.11 +/- 1.22, P=0.022). Conclusion: In up to 92% of the cystectomy samples, normal ovarian tissue was found adjacent to the benign cyst; however, functional follicle loss was slightly, but significantly, higher in the endometriomas. (C) 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved