On Maximum Margin Hierarchical Classification

We present work in progress towards maximum margin hierarchical classification where the objects are allowed to belong to more than one category at a time. The classification hierarchy is represented as a Markov network equipped with an exponential family defined on the edges. We present a variation of the maximum margin multilabel learning framework, suited to the hierarchical classification task and allows efficient implementation via gradient-based methods. We compare the behaviour of the proposed method to the recently introduced hierarchical regularized least squares classifier as well as two SVM variants in Reuter's news article classification

Gender Differences in Political Participation: Comparing Street Demonstrators in Sweden and the United Kingdom

This is the author accepted manuscript. The final version is available from SAGE Publications via the DOI in this record.Research on gender and politics has primarily focused on women’s participation in women’s movements and institutional politics separately. Our paper is innovative in multiple respects: First, employing a comparative perspective we analyse what impact gender regimes have on participation in street protests. Second, we study the relationship between participation in electoral and protest politics and how this relationship is gendered. Third, we compare the participation of men and women in social movements. We are able to do this by drawing on nuanced survey data of five street demonstrations in the UK and Sweden which we benchmark against the more widely used European Social Survey. Our comparative research demonstrates that involvement in protest and institutional politics varies by gender, country and context. Our findings have important implications for gender equality in terms of social inclusion and political representation and contribute to political sociology, sociology of gender, and social movement research.Economic and Social Research Council (ESRC)British Academ

Do gender regimes matter? Gender differences in involvement in anti-austerity protests - a comparison of Spain, Sweden and the United Kingdom

This is the final version. Available on open access from Taylor & Francis (Routledge) via the DOI in this record.Responses to the Great Recession are varied across welfare states and gendered in their consequences. Combining gender, social policy and social movement scholarship, this paper investigates how the differential policy responses to the Financial Crisis in three European countries shaped gender-differences in anti-austerity demonstrations. We compare the involvement and characteristics of women and men in anti-austerity protests using data collected at street demonstrations (2010–2012). We conduct cross-national multi-level analysis of demonstrators from countries representing different gender regimes (Spain, Sweden and the United Kingdom). Our results show that gender regimes have a significant impact on women’s and men’s involvement in anti-austerity protests. We thus make an important contribution to research on gender differences in participation in anti-austerity demonstrations post-Great Recession. Our comparison of women’s and men’s participation in anti-austerity street demonstrations suggests that at the country or regime level resources matter more than grievances, but that grievances matter at the individual level. This innovative paper links scholarship on gender regimes with research on protest participation. Resources and experiences of grievances are shaped by gender regimes which provide access to decision-making and social support. We reveal novel insights into the connection between gender regimes and demonstration participation.Economic and Social Research Council (ESRC)European CommissionEuropean Science Foundatio

Clustering of the Diffuse Infrared Light from the COBE DIRBE maps. III. Power spectrum analysis and excess isotropic component of fluctuations

The cosmic infrared background (CIB) radiation is the cosmic repository for energy release throughout the history of the universe. Using the all-sky data from the COBE DIRBE instrument at wavelengths 1.25 - 100 mic we attempt to measure the CIB fluctuations. In the near-IR, foreground emission is dominated by small scale structure due to stars in the Galaxy. There we find a strong correlation between the amplitude of the fluctuations and Galactic latitude after removing bright foreground stars. Using data outside the Galactic plane ($|b| > 20\deg$) and away from the center ($90\deg< l <270\deg$) we extrapolate the amplitude of the fluctuations to cosec$|b|=0$. We find a positive intercept of $\delta F_{\rm rms} = 15.5^{+3.7}_{-7.0},5.9^{+1.6}_{-3.7}, 2.4^{+0.5}_{-0.9}, 2.0^{+0.25}_{-0.5}$ nW/m2/sr at 1.25, 2.2,3.5 and 4.9 mic respectively, where the errors are the range of 92% confidence limits. For color subtracted maps between band 1 and 2 we find the isotropic part of the fluctuations at $7.6^{+1.2}_{-2.4}$ nW/m2/sr. Based on detailed numerical and analytic models, this residual is not likely to originate from the Galaxy, our clipping algorithm, or instrumental noise. We demonstrate that the residuals from the fit used in the extrapolation are distributed isotropically and suggest that this extra variance may result from structure in the CIB. For 2\deg< \theta < 15^\deg, a power-spectrum analysis yields firm upper limits of (\theta/5^\deg) \times\delta F_{\rm rms} (\theta) < 6, 2.5, 0.8, 0.5 nW/m2/sr at 1.25, 2.2, 3.5 and 4.9 mic respectively. From 10-100 mic, the upper limits <1 nW/m2/sr.Comment: Ap.J., in press. 69 pages including 24 fig

Discrete Formulation for the dynamics of rods deforming in space

We describe the main ingredients needed to create, from the smooth lagrangian density, a variational principle for discrete motions of a discrete rod, with corresponding conserved Noether currents. We describe all geometrical objects in terms of elements on the linear Atiyah bundle, using a reduced forward difference operator. We show how this introduces a discrete lagrangian density that models the discrete dynamics of a discrete rod. The presented tools are general enough to represent a discretization of any variational theory in principal bundles, and its simplicity allows to perform an iterative integration algorithm to compute the discrete rod evolution in time, starting from any predefined configurations of all discrete rod elements at initial times

Hybrid functionals within the all-electron FLAPW method: implementation and applications of PBE0

We present an efficient implementation of the PBE0 hybrid functional within the full-potential linearized augmented-plane-wave (FLAPW) method. The Hartree-Fock exchange term, which is a central ingredient of hybrid functionals, gives rise to a computationally expensive nonlocal potential in the one-particle Schroedinger equation. The matrix elements of this exchange potential are calculated with the help of an auxiliary basis that is constructed from products of FLAPW basis functions. By representing the Coulomb interaction in this basis the nonlocal exchange term becomes a Brillouin-zone (BZ) sum over vector-matrix-vector products. We show that the Coulomb matrix can be made sparse by a suitable unitary transformation of the auxiliary basis, which accelerates the computation of the vector-matrix-vector products considerably. Additionally, we exploit spatial and time-reversal symmetry to identify the nonvanishing exchange matrix elements in advance and to restrict the k summations for the nonlocal potential to an irreducible set of k points. Favorable convergence of the self-consistent-field cycle is achieved by a nested density-only and density-matrix iteration scheme. We discuss the convergence with respect to the parameters of our numerical scheme and show results for a variety of semiconductors and insulators, including oxide materials, where the PBE0 hybrid functional improves the band gaps and the description of localized states in comparison with the PBE functional. Furthermore, we find that in contrast to conventional local exchange-correlation functionals ferromagnetic EuO is correctly predicted to be a semiconductor.Comment: 15 pages, 6 figures, 2 table

A systematic review of the role of bisphosphonates in metastatic disease

Objectives: To identify evidence for the role of bisphosphonates in malignancy for the treatment of hypercalcaemia, prevention of skeletal morbidity and use in the adjuvant setting. To perform an economic review of current literature and model the cost effectiveness of bisphosphonates in the treatment of hypercalcaemia and prevention of skeletal morbidity Data sources: Electronic databases (1966-June 2001). Cochrane register. Pharmaceutical companies. Experts in the field. Handsearching of abstracts and leading oncology journals (1999-2001). Review methods: Two independent reviewers assessed studies for inclusion, according to predetermined criteria, and extracted relevant data. Overall event rates were pooled in a meta-analysis, odds ratios ( OR) were given with 95% confidence intervals (CI). Where data could not be combined, studies were reported individually and proportions compared using chi- squared analysis. Cost and cost-effectiveness were assessed by a decision analytic model comparing different bisphosphonate regimens for the treatment of hypercalcaemia; Markov models were employed to evaluate the use of bisphosphonates to prevent skeletal-related events (SRE) in patients with breast cancer and multiple myeloma. Results: For acute hypercalcaemia of malignancy, bisphosphonates normalised serum calcium in >70% of patients within 2-6 days. Pamidronate was more effective than control, etidronate, mithramycin and low-dose clodronate, but equal to high dose clodronate, in achieving normocalcaemia. Pamidronate prolongs ( doubles) the median time to relapse compared with clodronate or etidronate. For prevention of skeletal morbidity, bisphosphonates compared with placebo, significantly reduced the OR for fractures (OR [95% CI], vertebral, 0.69 [0.57-0.84], non-vertebral, 0.65 [0.54-0.79], combined, 0.65 [0.55-0.78]) radiotherapy 0.67 [0.57-0.79] and hypercalcaemia 0.54 [0.36-0.81] but not orthopaedic surgery 0.70 [0.46-1.05] or spinal cord compression 0.71 [0.47-1.08]. However, reduction in orthopaedic surgery was significant in studies that lasted over a year 0.59 [0.39-0.88]. Bisphosphonates significantly increased the time to first SRE but did not affect survival. Subanalyses were performed for disease groups, drugs and route of administration. Most evidence supports the use of intravenous aminobisphosphonates. For adjuvant use of bisphosphonates, Clodronate, given to patients with primary operable breast cancer and no metastatic disease, significantly reduced the number of patients developing bone metastases. This benefit was not maintained once regular administration had been discontinued. Two trials reported significant survival advantages in the treated groups. Bisphosphonates reduce the number of bone metastases in patients with both early and advanced breast cancer. Bisphosphonates are well tolerated with a low incidence of side-effects. Economic modelling showed that for acute hypercalcaemia, drugs with the longest cumulative duration of normocalcaemia were most cost-effective. Zoledronate 4 mg was the most costly, but most cost-effective treatment. For skeletal morbidity, Markov models estimated that the overall cost of bisphosphonate therapy to prevent an SRE was pound250 and pound1500 per event for patients with breast cancer and multiple myeloma, respectively. Bisphosphonate treatment is sometimes cost-saving in breast cancer patients where fractures are prevented. Conclusions: High dose aminobisphosphonates are most effective for the treatment of acute hypercalcaemia and delay time to relapse. Bisphosphonates significantly reduce SREs and delay the time to first SRE in patients with bony metastatic disease but do not affect survival. Benefit is demonstrated after administration for at least 6-12 months. The greatest body of evidence supports the use of intravenous aminobisphosphonates. Further evidence is required to support use in the adjuvant setting