1,257 research outputs found
Influencing Choices by Changing Beliefs: A Logical Theory of Influence, Persuasion, and Deception
Wemodelpersuasion,viewedasadeliberateactionthroughwhichan agent (persuader) changes the beliefs of another agent’s (persuadee). This notion of persuasion paves the way to express the idea of persuasive influence, namely inducing a change in the choices of the persuadee by changing her beliefs. It allows in turns to express different aspects of deception. To this end, we propose a logical framework that enables expressing actions and capabilities of agents, their mental states (desires, knowledge and beliefs), a variety of agency operators as well as the connection between mental states and choices. Those notions, once combined, enable us to capture, the notion of influence, persuasion and deception, as well as their relation
Isospin splitting of the nucleon mean field
The isospin splitting of the nucleon mean field is derived from the Brueckner
theory extended to asymmetric nuclear matter. The Argonne V18 has been adopted
as bare interaction in combination with a microscopic three body force. The
isospin splitting of the effective mass is determined from the
Brueckner-Hartree-Fock self-energy: It is linear acording to the Lane ansatz
and such that for neutron-rich matter. The symmetry potential
is also determined and a comparison is made with the predictions of the
Dirac-Brueckner approach and the phenomenological interactions. The theoretical
predictions are also compared with the empirical parametrizations of neutron
and proton optical-model potentials based on the experimental nucleon-nucleus
scattering and the phenomenological ones adopted in transport-model simulations
of heavy-ion collisions. The direct contribution of the rearrangement term due
to three-body forces to the single particle potential and symmetry potential is
discussed.Comment: 8 pages, 10 figure
OWL-POLAR : semantic policies for agent reasoning
The original publication is available at www.springerlink.comPostprin
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First Report of NRG Oncology/Radiation Therapy Oncology Group 0622: A Phase 2 Trial of Samarium-153 Followed by Salvage Prostatic Fossa Irradiation in High-Risk Clinically Nonmetastatic Prostate Cancer After Radical Prostatectomy.
PURPOSE: To investigate the utility of 153Sm lexidronam (Quadramet) in the setting of men with prostate cancer status post radical prostatectomy who develop biochemical failure with no clinical evidence of osseous metastases.
PATIENTS AND METHODS: Trial NRG Oncology RTOG 0622 is a single-arm phase 2 trial that enrolled men with pT2-T4, N0-1, M0 prostate cancer status post radical prostatectomy, who meet at least 1 of these biochemical failure criteria: (1) prostate-specific antigen (PSA) \u3e 1.0 ng/mL; (2) PSA \u3e 0.2 ng/mL if Gleason score 9 to 10; or (3) PSA \u3e 0.2 ng/mL if N1. Patients received 153Sm (2.0 mCi/kg intravenously × 1) followed by salvage external beam radiation therapy (EBRT) to the prostatic fossa (64.8-70.2 Gy in 1.8-Gy daily fractions). No androgen deprivation therapy was allowed. The primary objective was PSA response within 12 weeks of receiving 153Sm. The secondary objectives were to: (1) assess the completion rate for the regimen of 153Sm and EBRT; (2) evaluate the hematologic toxicity and other adverse events (AEs) at 12 and 24 weeks; and (3) determine the freedom from progression rate at 2 years.
RESULTS: A total of 60 enrolled eligible patients were included in this analysis. Median follow-up was 3.97 years. A PSA response was achieved in 7 of 52 evaluable patients (13.5%), compared with the 25% hypothesized. The 2-year freedom from progression rate was 25.5% (95% confidence interval 14.4%-36.7%), and the biochemical failure rate was 64.4% (95% CI 50.5%-75.2%). Samarium-153 was well tolerated, with 16 (of 60) grade 3 to 4 hematologic AEs and no grade 5 hematologic AEs. Radiation therapy was also well tolerated, with no grade 3 to 5 acute radiation therapy-related AEs and 1 grade 3 to 4 and no grade 5 late radiation therapy-related AEs.
CONCLUSIONS: Trial NRG Oncology RTOG 0622 did not meet its primary endpoint of PSA response, although the regimen of 153Sm and salvage EBRT was well tolerated. Although the toxicity profile supports study of 153Sm in high-risk disease, it may not be beneficial in men receiving EBRT
Environmental influences predominate in remission from alcohol use disorder in young adult twins
Background. Familial influences on remission from alcohol use disorder (AUD) have been studied using family history of AUD rather than family history of remission. The current study used a remission phenotype in a twin sample to examine the relative contributions of genetic and environmental influences to remission
Common genetic and environmental contributions to post-traumatic stress disorder and alcohol dependence in young women
BACKGROUND: The few genetically informative studies to examine post-traumatic stress disorder (PTSD) and alcohol dependence (AD), all of which are based on a male veteran sample, suggest that the co-morbidity between PTSD and AD may be attributable in part to overlapping genetic influences, but this issue has yet to be addressed in females. METHOD: Data were derived from an all-female twin sample (n=3768) ranging in age from 18 to 29 years. A trivariate genetic model that included trauma exposure as a separate phenotype was fitted to estimate genetic and environmental contributions to PTSD and the degree to which they overlap with those that contribute to AD, after accounting for potential confounding effects of heritable influences on trauma exposure. RESULTS: Additive genetic influences (A) accounted for 72 % of the variance in PTSD ; individual-specific environmental (E) factors accounted for the remainder. An AE model also provided the best fit for AD, for which heritability was estimated to be 71 %. The genetic correlation between PTSD and AD was 0.54. CONCLUSIONS: The heritability estimate for PTSD in our sample is higher than estimates reported in earlier studies based almost exclusively on an all-male sample in which combat exposure was the precipitating traumatic event. However, our findings are consistent with the absence of evidence for shared environmental influences on PTSD and, most importantly, the substantial overlap in genetic influences on PTSD and AD reported in these investigations. Additional research addressing potential distinctions by gender in the relative contributions of genetic and environmental influences on PTSD is merited
Epigenome‐wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/133545/1/em22024.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133545/2/em22024_am.pd
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