The effects of soccer-specific intermittent exercise on salivary IgA responses

Exercise has been demonstrated to influence susceptibility to upper respiratory tract infections (URTI) because various aspects of immune function including mucosal immunity are temporarily changed after exercise. Lower concentrations of salivary 19A (s-IgA) as a predominant immunoglobulin and component of saliva or a chronic deficiency in s-IgA have been associated with an increased frequency of URTI episodes. Previous studies of aerobic exercise have incorporated the performance of running or cycling. Responses of s-19A to intermittent exercise patterns as they occur in soccer remain to be resolved. A laboratory based soccerspecific intermittent exercise protocol was used within this thesis to mimic the physiological stress associated with soccer, characterised by highintensity activity as noted during soccer play. The aims of this thesis were to determine the s-IgA responses to a bout or repeated bouts of soccerspecific intermittent exercise and investigate the effects of carbohydrate ingestion on s-IgA when such exercise is performed in increased ambient temperature. Laboratory based soccer-specific intermittent exercise and continuous exercise at the same moderate exercise intensity evoked insufficient stimulation of the hypothalamic-pituitary-adrenal axis to modify s-IgA responses. Changes in s-19A and cortisol did not differ between exercise types during or immediately following exercise, or 6 h, 24 h and 48 h afterwards. Physiological responses to intermittent exercise also conforming to the activity pattern of soccer match-play were similar to those for continuous exercise at the same average work-rate, despite the higher perceived exertion during intermittent exercise. Two bouts of soccer-specific intermittent exercise 48 h apart that were designed to provide a repeatable physiological stress comparable to strenuous soccer training induced s-19A responses that were similar following both bouts of exercise. Performing the second bout of exercise did not significantly suppress s-IgA concentration after 48 h recovery although a small progressive reduction in s-19A was observed. Performance of a second soccer-specific exercise bout in one day with a 2.25 h rest in between bouts elicited an increase in heart rate and perceived exertion, compared with a single session at the same time of day, but did not appear to suppress s-IgA outcomes. There was also no difference between responses of s-IgA concentration and secretion rate or salivary cortisol at the different times of day. Soccer can be played under hot environmental conditions and it is thought that addition of carbohydrate to fluids may prevent adverse changes in mucosal immune responses. Carbohydrate supplementation before and at regular intervals whilst performing soccer-specific intermittent exercise at 30°C, did not influence s-IgA responses or salivary cortisol when compared to placebo. In view of the failure of these experimental interventions to discern effects on s-IgA responses, a meta-analysis of the literature was conducted. The meta-analysis revealed an overall elevation in s-IgA concentration post acute exercise and following chronic exercise. In contrast, in term of s-IgA secretion rate, an overall significant decline after both acute and chronic exercise was a consistent finding. In conclusion, one exercise bout or repeated soccer-specific intermittent exercise in the present experiments did not induce compromises in s-IgA responses. There was no adverse effect upon s-IgA responses to intermittent exercise performance under conditions of heat stress with or without carbohydrate treatment. Although, 32 percent of studies included in the meta-analysis have indicated similar results, the disparity with overall findings may arise from differences in the exercise protocols used and/or bias for s-IgA changes in published studies

A combined continuous and interval aerobic training improves metabolic syndrome risk factors in men.

Individuals with metabolic syndrome have significantly higher risk for cardiovascular disease, Type 2 diabetes leading to premature death mortality. Metabolic syndrome has a complex aetiology, thus it may require a combined and multi-targeted aerobic exercise regimen to improve risk factors associated with the metabolic syndrome. Therefore, the aim of this study was to evaluate the effect of combined continuous and interval aerobic training on patients with metabolic syndrome. Thirty adult male with metabolic syndrome (54±8 years) were randomly divided into two groups: Test Training Group (TTG; n=15) or Control Group (CG; n=15). Subjects in TTG group performed combined continuous and interval aerobic training using a motorised treadmill three times per week for 16 weeks. Subjects in CG group were advised to continue with their normal activities of life. Twenty-two men completed the study (11 men in each group). At the end of the study, in TTG group, there were significant (for all, P<0.05) reductions in total body weight (-3.2%), and waist circumference (-3.43 cm), blood pressure (BP; up to -12.7 mmHg), plasma insulin, glucose and triacylglycerides levels. Moreover, there were significant (for all, P<0.05) increases in VO2max (-15.3%) and isometric strength of thigh muscle (28.1%) and HDL in TTG group. None of the above indices were changed in CG group at the end of 16 week study period. Our study suggests that adoption of a 16 week combined continuous and interval aerobic training regimen in men with metabolic syndrome could significantly reduce cardiovascular risk factors in these patients

Acute exercise and appetite-regulating hormones in overweight and obese individuals: A meta-analysis

In lean individuals, acute aerobic exercise is reported to transiently suppress sensations of appetite, suppress blood-concentrations of acylated ghrelin (AG) and increase glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY). Findings in overweight/obese individuals have yet to be synthesised. In this systematic review and meta-analysis, we quantified the effects acute exercise has on AG, total PYY and GLP-1 in overweight/obese individuals. The potential for body mass index (BMI) to act as a moderator for AG was also explored. Six published studies (73 participants, 78% male, mean BMI: 30.6 kg.m-2) met the inclusion criteria. Standardised mean differences (SMD) and standard errors were extracted for AG, total PYY and GLP-1 concentrations in control and exercise trials and synthesised using a random effects meta-analysis model. BMI was the predictor in a meta-regression for AG. Exercise moderately suppressed AG area-under-the-curve concentrations (pooled SMD -0.34, 95%CI: -0.53 to -0.15). The magnitude of this reduction was greater for higher mean BMIs (pooled meta-regression slope: -0.04 SMD/kg.m-2 (95%CI: -0.07 to 0.00)). Trivial SMDs were obtained for total PYY (0.10, 95%CI: -0.13 to 0.31) and GLP-1 (-0.03, 95%CI: -0.18 to 0.13). This indicates that exercise in overweight/obese individuals moderately alters AG in a direction that could be associated with decreased hunger and energy intake. (PROSPERO registration: CRD42014006265)

Acute Exercise and Appetite-Regulating Hormones in Overweight and Obese Individuals: A Meta-Analysis.

In lean individuals, acute aerobic exercise is reported to transiently suppress sensations of appetite, suppress blood concentrations of acylated ghrelin (AG), and increase glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY). Findings in overweight/obese individuals have yet to be synthesised. In this systematic review and meta-analysis, we quantified the effects that acute exercise has on AG and total PYY and GLP-1 in overweight/obese individuals. The potential for body mass index (BMI) to act as a moderator for AG was also explored. Six published studies (73 participants, 78% male, mean BMI: 30.6 kg·m-2) met the inclusion criteria. Standardised mean differences (SMDs) and standard errors were extracted for AG and total PYY and GLP-1 concentrations in control and exercise trials and synthesised using a random effects meta-analysis model. BMI was the predictor in metaregression for AG. Exercise moderately suppressed AG area-under-the-curve concentrations (pooled SMD: -0.34, 95% CI: -0.53 to -0.15). The magnitude of this reduction was greater for higher mean BMIs (pooled metaregression slope: -0.04 SMD/kg·m-2 (95% CI: -0.07 to 0.00)). Trivial SMDs were obtained for total PYY (0.10, 95% CI: -0.13 to 0.31) and GLP-1 (-0.03, 95% CI: -0.18 to 0.13). This indicates that exercise in overweight/obese individuals moderately alters AG in a direction that could be associated with decreased hunger and energy intake. This trial is registered with PROSPERO: CRD42014006265

Effects of aerobic and exhaustive exercise on salivary and serum total antioxidant capacity and lipid peroxidation indicators in sedentary men

Background: Some studies have shown that aerobic exercise could promote the antioxidant defense system. Therefore, the aim of present study was to investigate the effects of aerobic and single bout of exhaustive exercise on salivary and serum malondialdehyde (MDA) and total antioxidant capacity (TAC) in non-athlete males. Materials and Methods: Twenty-seven male (age: 18-21 year) were randomly assigned into Control (n=12) and Aerobic-training (n=15) groups. Training group was participated in an aerobic exercise program (50-70 of Heart Rate Reserve) for 8 weeks (three times per week). After the termination of exercise program, both groups performed a progressive exercise to exhaustion on treadmill. To evaluate the MDA and TAC, serum and salivary samples were collected before and after the training as well as after the exhaustive exercise. Results: Aerobic exercise caused a significant increase in salivary and serum TAC (P&lt;0.05). Moreover, the intensive exercise reduced the serum TAC in Control group (P&lt;0.05). After the termination of exercise program, serum MDA was lower in Training group than the Control one, while no difference was noted for salivary measurement. A significant rise in serum MDA was found in Control group after the exhaustive exercise (P&lt;0.05). However, there was no significant relationship between the salivary and serum TAC and MDA levels. Conclusion: Aerobic exercise could be effective in preventing the exhaustive exercise-induced lipid peroxidation. Although the interpretation of results on salivary parameters require further studies

The effect of grape seed (Vitis vinifera L.) extract supplementation on lipid profile and high-sensitivity C-reactive protein levels after aerobic exercise in non-athlete males

Background: There are a few studies about the positive effects of exercise and polyphenols supplementation on reduction of cardiovascular risk factors. Therefore, this study aimed to investigate the effect of short-term grape seed extract (GSE) supplementation on lipid profile and high-sensitivity C-reactive protein (hs-CRP) levels after an aerobic exercise in non-athlete men. Materials and Methods: In a randomized double-blind study, 20 non-athlete men (age range, 19±1 years, body fat 12.20±3, body mass index 22.22±2, and VO2max 39.28±2 ml.kg-1.min-1) were allocated into two equal groups (n=10): the GSE supplementation (200 mg/day) and placebo groups. The hs-CRP, triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) and total cholesterol (TC) levels were measured before and after the supplementation and after an aerobic exercise protocol with 75 VO2max on the motorized treadmill for 30 minutes. Results: The results showed a significant reduction in TG and a significant increase in hs-CRP after the exercise in both groups (P0.05). In addition, there was a significant decrease in TC levels subsequent GSE supplementation (

Comparing the effects of combined endurance-resistance training versus resistance-endurance on growth hormone and insulin-like growth factor-I in non-athlete prepubertal girls

Background: In children and adolescents, the anabolic effects of exercise are mediated through growth hormone (GH) and insulin-like growth factor-I (IGF-I). Therefore, this study aimed to compare the effects of combined endurance-resistance versus resistance-endurance exercises on GH and IGF-I in non-athlete prepubertal girls. Materials and Methods: In this semi-experimental study, 16 prepubertal girls aged 9-11 years old, after homogenization, were randomly allocated into two equal groups (n=8): the endurance-resistance and resistance-endurance. Activities in both groups included combined endurance (20 minutes of moderate-intensity aerobic exercise with 60-70 of the maximal oxygen uptake (VO2max) on a treadmill)-resistance (biceps, triceps, chest press, butterfly, knee extension and flexion, moderate leg press with 60 of 1-RM, and 1 set of 10 repetitions) and resistance-endurance training with different orders. Before, immediately after and 2 hours after the exercise, blood samples were taken and GH and IGF-1 levels were measured. Results: Immediately after the training, in both group, GH levels (3.39 ng/ml vs 1.8 ng/ml) were significantly increased compared to the resting condition (0.77 ng/ml vs 0.72 ng/ml) (P=0.017). However, GH levels (0.97 ng/ml vs 0.18 ng/ml) were significantly decreased in both groups after 2 hours (P=0.012). The GH levels in the endurance-resistance group were higher compared to the resistance-endurance group. Changes in IGF-1 levels in both training groups before, immediately after and 2 hours after the training did not show significant differences.Conclusion: It seems that combined endurance-resistance training is more appropriate option for non-athlete prepubertal girls