Utilità dello screening ecografico delle cardiopatie congenite nelle gravide a basso rischio

La valutazione dell’integrità del cuore fetale è data dallo studio delle 4 camere durante l’ecografia morfologica del secondo trimestre, mentre nelle gravide cosiddette a rischio per cardiopatie congenite viene consigliato l’ecocardio fetale, dove oltre alle 4 camere vengono analizzate le altre strutture cardiache ed anche la loro funzionalità. La frequenza delle cardiopatie congenite, però, è del: 25-30% nelle gravide a rischio e del 70-75% nelle gravide a basso rischio. Nella nostra divisione di ostetricia abbiamo effettuato un test di screening su 1.030 gravide tra la 20ª e 24ª settimana considerate a basso rischio. Il test prevede lo studio delle 4-camere, dell’asse lungo sn, dell’asse lungo dx e dell’arco aortico. Le stesse scansioni vengono poi valutate con il color-Doppler. Il test è risultato positivo in 7 casi

Correlazione tra anomalie flussimetriche ed outcome in feti con IUGR

Il ritardo di crescita intrauterino (IUGR, Intrauterine Growth Restriction) (peso fetale <10° percentile) è una condizione patologica che complica la gravidanza in circa il 15% dei casi (1). La flussimetria Doppler dei vasi fetali e il profilo biofisico fetale rappresentano a tutt’oggi la metodica più efficace nonché l’unica disponibile per la sorveglianza del feto con IUGR (5). Abbiamo monitorizzato 33 gravide con IUGR comparso dopo la 27ª settimana; le pazienti sono state divise in 3 gruppi a seconda della settimana di comparsa del ritardo. Tutte le pazienti sono state sottoposte ad intervalli regolari a: valutazione biometrica, flussimetria arteriosa e venosa, calcolo AFI, CTG. L’outcome neonatale peggiore si è avuto nel 3° gruppo. Scopo del nostro studio è stato quello di verificare la correlazione tra anomalie della flussimetria fetale e outcome neonatale in feti con IUGR (CA < 10° percentile). Da quanto emerso dai risultati si può comprendere come l’epoca di comparsa del ritardo di crescita sia di grande rilevanza per la prognosi neonatale (8)

Energy release as a parameter for fatigue design of additive manufactured metals

Additive manufacturing (AM) is spreading in a wide range of industrial fields. The influence of the printing parameters on the mechanical performance is still an open issue among researchers, particularly when dealing with fatigue loads, which can lead to an unexpected failure. Classical fatigue tests require a large amount of time and materials to be consumed. Compared to the traditional fatigue assessment, the thermographic method (TM) is able to derive in a very rapid way the SN curve and fatigue limit of the material monitoring its energetic release during fatigue tests. In this work, for the first time, the energetic release during fatigue test has been evaluated in specimens made of AISI 316L, obtained by SLM technique. Compared to literature data, the specimens show premature failure, even at low stress levels, with brittle fracture surfaces. The internal microstructure seems to be strictly related to the energetic release of the material

thermographic analysis during tensile tests and fatigue assessment of s355 steel

Abstract Structural S355 steel is widely applied in various sectors. Fatigue properties are of fundamental importance and extremely time consuming to be assessed. The aim of this research activity is to apply the Static Thermographic Method during tensile tests and correlate the temperature trend to the fatigue properties of the same steel. The Digital Image Correlation (DIC) and Infrared Thermography (IR) techniques have been used during all static tests. The Digital Image Correlation technique allowed the detection of displacements and strain, and so the evaluation of the mechanical properties of the material. Traditional fatigue tests were also performed in order to evaluate the stress-number of cycles to failure curve of the same steel. The value of the fatigue limit, obtained by the traditional procedure, was compared with the values predicted by means of the Static Thermographic Method (STM) obtained from tensile tests. The predicted values are in good agreement with the experimental values of fatigue life

New frontiers on adjuvants drug strategies and treatments in periodontitis

Causes of the progression of periodontitis such as an imbalance between the immune response by the host by the release of inflammatory mediators in the response of the oral pathogenic dysbiotic biofilm have been identified. New insights on specific cell signaling pathways that appear during periodontitis have attracted the attention of researchers in the study of new personalised approaches for the treatment of periodontitis. The gold standard of non‐surgical therapy of perio-dontitis involves the removal of supra and subgingival biofilm through professional scaling and root planing (SRP) and oral hygiene instructions. In order to improve periodontal clinical outcomes and overcome the limitations of traditional SRP, additional adjuvants have been developed in recent decades, including local or systemic antibiotics, antiseptics, probiotics, anti‐inflammatory and anti-resorptive drugs and host modulation therapies. This review is aimed to update the current and recent evolution of therapies of management of periodontitis based on the adjunctive and target therapies. Moreover, we discuss the advances in host modulation of periodontitis and the impact of targeting epigenetic mechanisms approaches for a personalised therapeutic success in the management of periodontitis. In conclusion, the future goal in periodontology will be to combine and personalise the periodontal treatments to the colonising microbial profile and to the specific response of the individual patient

Curcumin loaded polymeric vs. Lipid nanoparticles: Antioxidant effect on normal and hypoxic olfactory ensheathing cells

Background: Curcumin (Cur) shows anti-inflammatory and antioxidant effects on central nervous system diseases. The aim of this study was to develop Cur-loaded polymeric and lipid nanoparticles for intranasal delivery to enhance its stability and increase antioxidant effect on olfactory ensheathing cells (OECs). Methods: The nanosuspensions were subjected to physico-chemical and technological evaluation through photon correlation spectroscopy (PCS), differential scanning calorimetry (DSC) and UV-spectrophotometry. The cytotoxicity studies of nanosuspensions were carried out on OECs. A viability test was performed after 24 h of exposure of OECs to unloaded and curcumin-loaded nanosuspensions. The potential protective effect of Cur was assessed on hypoxic OECs cells. Uptake studies were performed on the same cell cultures. Thermal analysis was performed to evaluate potential interaction of Cur with a 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) biomembrane model. Results: PCS analysis indicated that lipid and polymeric nanosuspensions showed a mean size of 127.10 and 338.20 nm, respectively, high homogeneity and negative zeta potential. Incorporation of Cur into both nanocarriers increased drug stability up to 135 days in cryoprotected freeze-dried nanosuspensions. Cell viability was improved when hypoxic OECs were treated with Cur-loaded polymeric and lipid nanosuspensions compared with the control. Conclusions: Both nanocarriers could improve the stability of Cur as demonstrated by technological studies. Biological studies revealed that both nanocarriers could be used to deliver Cur by intranasal administration for brain targeting

fatigue life evaluation of car front halfshaft

Abstract The present paper is the result of the collaboration between the Engineering Department of Messina University and the car company Maserati S.p.A. The aim of this paper is to determine the T-N torsion fatigue curve at R= -1 of the mechanical system "front halfshaft" of an existing car. In particular, experimental fatigue tests were carried out in the laboratories of the Engineering Department of the University of Messina. Torsion fatigue tests of the entire mechanical system were carried out on 15 different front halfshafts. Evaluations of the crack propagation and of failure analysis were made to determine the causes of breakage. In conclusion, the T-N fatigue curve of the mechanical system "front halfshaft" has been obtained

Impact of Periodontitis on Glycemic Control and Metabolic Status in Diabetes Patients: Current Knowledge on Early Disease Markers and Therapeutic Perspectives

Diabetes mellitus and periodontitis are two of the most common chronic diseases affecting the world's population, and they are intimately linked. For several years, in fact, it has been known that there is an interdependent relationship between the two diseases: Diabetes promotes the destruction of periodontal tissues, and periodontal disease negatively affects glycemic control. In relation to the control of dental plaque and oral dysbiosis responsible for periodontal disease, both nonsurgical and surgical therapy associated with proper home hygiene procedures have emerged as essential for good glycemic control. Moreover, several evidences suggest the essential role played by the control of periodontal disease in preventing the onset of the most common complications of diabetes: cardiovascular diseases, retinopathies, and other systemic diseases. The aim of this study is to update the current knowledge on the bi-univocal relationship between diabetes and periodontitis and the impact of therapy in the optimal management of these two disorders. From the information found in the literature, it has emerged that the correct treatment of periodontal disease in diabetic patients represents one of the main mechanisms and means currently established and valid to control periodontal disease and glucose metabolism and prevent the onset or development of diabetic complications

Water extract of Cryphaea heteromalla (Hedw.) D. Mohr bryophyte as a natural powerful source of biologically active compounds

Bryophytes comprise of the mosses, liverworts, and hornworts. Cryphaea heteromalla, (Hedw.) D. Mohr, is a non-vascular lower plant belonging to mosses group. To the date, the most chemically characterized species belong to the liverworts, while only 3.2% and 8.8% of the species belonging to the mosses and hornworts, respectively, have been investigated. In this work, we present Folin–Ciocalteu and oxygen radical absorbance capacity (ORAC) data related to crude extracts of C. heteromalla obtained by three different extraction solvents: pure water (WT), methanol:water (80:20 v/v) (MET), and ethanol:water (80:20 v/v) (ETH). The water extract proved to be the best solvent showing the highest content of biophenols and the highest ORAC value. The C. heteromalla-WT extract was investigated by HPLC-TOF/MS (High Performance Liquid Chromatography-Time of Flight/Mass Spectrometry) allowing for the detection of 14 compounds, five of which were phenolic compounds, derivatives of benzoic, caffeic, and coumaric acids. Moreover, the C. heteromalla WT extract showed a protective effect against reactive oxygen species (ROS) generation induced by tert-butyl hydroperoxide (TBH) on the murine NIH-3T3 fibroblast cell line

Toward the use of temporary tattoo electrodes for impedancemetric respiration monitoring and other electrophysiological recordings on skin

The development of dry, ultra-conformable and unperceivable temporary tattoo electrodes (TTEs), based on the ink-jet printing of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) on top of commercially available temporary tattoo paper, has gained increasing attention as a new and promising technology for electrophysiological recordings on skin. In this work, we present a TTEs epidermal sensor for real time monitoring of respiration through transthoracic impedance measurements, exploiting a new design, based on the application of soft screen printed Ag ink and magnetic interlink, that guarantees a repositionable, long-term stable and robust interconnection of TTEs with external “docking” devices. The efficiency of the TTE and the proposed interconnection strategy under stretching (up to 10%) and over time (up to 96 h) has been verified on a dedicated experimental setup and on humans, fulfilling the proposed specific application of transthoracic impedance measurements. The proposed approach makes this technology suitable for large-scale production and suitable not only for the specific use case presented, but also for real time monitoring of different bio-electric signals, as demonstrated through specific proof of concept demonstrators