Complexes of Organic Arsonic Acids: Part VIII - Complexes of VO2+ & Cu2+ with Arylarsonic Acids

988-99

Parasexual analysis in Trichoderma reesei using protoplast fusion

Protoplast fusion techniques were used to induce parasexuality in Trichoderma reesei and the products of fusion and segregation analyzed in order to get genetic data regarding the three cellulase markers, exoglucanase (exo), endoglucanase (endo) and beta-glucosidase ( beta- glu) and their location with respect to other auxotrophic markers. Five mutants derived from T. reesei QM 9414, a hypercellulase producer, were used in this study

Subgap Two-Photon States in Polycyclic Aromatic Hydrocarbons: Evidence for Strong Electron Correlations

Strong electron correlation effects in the photophysics of quasi-one-dimensional $\pi$-conjugated organic systems such as polyenes, polyacetylenes, polydiacetylenes, etc., have been extensively studied. Far less is known on correlation effects in two-dimensional $\pi$-conjugated systems. Here we present theoretical and experimental evidence for moderate repulsive electron-electron interactions in a number of finite polycyclic aromatic hydrocarbon molecules with $D_{6h}$ symmetry. We show that the excited state orderings in these molecules are reversed relative to that expected within one-electron and mean-field theories. Our results reflect similarities as well as differences in the role and magnitude of electron correlation effects in these two-dimensional molecules compared to those in polyenes.Comment: 11 pages, 5 figures, 2 table

Immunohistochemical expression of p16INK4a in premalignant lesions and malignant tumours of cervix

Background: Cervical carcinoma is the third most common cancer in women worldwide and firth most common cause of cancer related deaths. Human Papilloma virus, the most common cause of cervical cancer, causes functional inactivation of pRb, resulting in overexpression of p16INK4a. The overexpression of p16INK4a correlates well with the degree of cervical dysplasia and neoplasia. The present study is done to determine the IHC expression of p16INK4a so that it may be used as a biomarker for HPV and may play a role in the prevention, diagnosis and prognosis of cervical neoplasm. Methods: The present study was conducted on 60 formalin-fixed, paraffin-embedded specimens of cervical neoplasms, which comprised 47 cases of squamous cell carcinoma followed by 8 cases of adenocarcinoma, 3 cases of HSIL and 2 cases of LSIL. These were then subjected to IHC by p16INK4a. Cytoplasmic and nuclear positivity for p16INK4a was noted. Results: Overall 95% cases were positive for p16INK4a expression, 100% cases of adenocarcinoma, 98% cases of squamous cell carcinoma, 100% cases of HSIL and 0% cases of LSIL were positive for p16 expression. Conclusions: The present study showed statistical correlation of immunoreactivity of p16INK4a with histological type was clinically significant (p value <0.0001). In our study, p16INK4a immunohistochemical expression increased with increasing degree of dysplasia and with presence of cervical carcinoma

N terminus is key to the dominant negative suppression of CaV2 calcium channels: implications for episodic ataxia type 2

Expression of the calcium channels CaV2.1 and CaV2.2 is markedly suppressed by co-expression with truncated constructs containing Domain I. This is the basis for the phenomenon of dominant negative suppression observed for many of the episodic ataxia type 2 mutations in CaV2.1 that predict truncated channels. The process of dominant negative suppression has been shown previously to stem from interaction between the full-length and truncated channels and to result in downstream consequences of the unfolded protein response and endoplasmic reticulum-associated protein degradation. We have now identified the specific domain that triggers this effect. For both CaV2.1 and CaV2.2, the minimum construct producing suppression was the cytoplasmic N terminus. Suppression was enhanced by tethering the N terminus to the membrane with a CAAX motif. The 11-amino acid motif (including Arg52 and Arg54) within the N terminus, which we have previously shown to be required for G protein modulation, is also essential for dominant negative suppression. Suppression is prevented by addition of an N-terminal tag (XFP) to the full-length and truncated constructs. We further show that suppression of CaV2.2 currents by the N terminus-CAAX construct is accompanied by a reduction in CaV2.2 protein level, and this is also prevented by mutation of Arg52 and Arg54 to Ala in the truncated construct. Taken together, our evidence indicates that both the extreme N terminus and the Arg52, Arg54 motif are involved in the processes underlying dominant negative suppression

Study of Wind Turbine based SEIG under Balanced/Unbalanced Loads and Excitation

This paper presents the performance of a stand-alone self-excited induction generator (SEIG) driven by fixed pitch wind turbine. The main objective of the paper is: (i) dynamic study of SEIG under balanced R-L/R-C loads (ii) dynamic study of SEIG under balanced and unbalanced excitation, (iii) Fixed pitch wind turbine model has been considered for driving induction generator. An approach based on dynamic equations of an isolated SEIG under balanced/unbalanced conditions of loads is employed to study the behaviour of the system. The SEIG model with balanced/un-balanced load and excitation has been simulated using MATLAB/SIMULINK.DOI:http://dx.doi.org/10.11591/ijece.v2i3.30

Management of elderly patients with troponin positive chest pain in a District General Hospital

Background: The number of elderly patients that present with an acute coronary syndrome (ACS) is increasing, reflecting the growing number of people in the general population in this age group. The various guidelines do not generally specify a management strategy in this elderly group and the management is often at the discretion of the treating physician. We conducted an audit within our Cardiology Department to compare our practice of management of ACS in the elderly population based on the European Society of Cardiology guidelines. Methods: We conducted a retrospective analysis of the management of patients aged 80 and above that were admitted with troponin positive chest pain from 1st January to 31st December 2010. Patient information was primarily obtained from our computer data base system that includes blood results, ECHOs, diagnostic angiograms, discharge and clinic letters. If the information was inadequate we obtained patient files or contacted the relevant general practitioner. Results: Octo-nonagenarians represented just over a third (35%) of all patients that were admitted with a troponin positive event during the study period. We noted a 10% mortality rate observed in our study population over a 12 month period. Atrial fibrillation was an incidental finding in 22% of patients. Nearly half of these patients (49%) were managed by the cardiologists. 68% of these patients underwent diagnostic coronary angiography, of which 32% went on to have percutaneous coronary intervention and 7% underwent surgical intervention. Majority (80%) of patients that underwent angioplasty had more than 1 stent and 74% of patients required more than one coronary vessel to be stented. The length of stay in hospital was double for patients who were under the care of the general medical teams rather than the cardiology team. This group also had a higher number of other comorbidities such as dementia, malignancy, a history of gastro intestinal bleeds and chronic renal impairment. Conclusions: Octo and nonagenarians represent a significant proportion of our ACS patients. They have high mortality, greater number of comorbidities, diseased coronary vessels and if intervention was undertaken required more than one stent. Therefore, octo-nonagenarians represent a very complex group of patients. Guidelines and risk stratification are of limited value in this group as clinical trial data is currently lacking. Quality of life and risk to benefit assessments are of paramount importance in this group

Non-steady Force Measurement in an Orpheous Gas Turbine Engine Using Hydraulic Analogy

Determination of non-steady forces in a real turbine stage is difficult due to local flow conditions e.g. high pressure, high temperature and inaccessibility to the region etc. Experimentation in a real turbine is also prohibitive due to the costs involved. Recently, an alternative method of arriving at these non-steady forces through use of hydraulic analogy has been tried on flat plates. The paper describes the simulation of an orpheous gas turbine engine stage on the rotating water table. It discusses the modelling aspects and presents a comparison of the experimental and theoretical results obtained