Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

The predominant action of cilostazol on Aβ metabolism is likely to facilitate Aβ clearance due to the sustained cerebrovascular function in vivo. Our findings mechanistically demonstrate that cilostazol is a promising therapeutic approach for AD and CAA

Seções de referência de subsuperfície da aloformação Paranavaí

A Aloformação Paranavaí é uma unidade geológica quaternária definida na Bacia Hidrográfica do Alto Rio Paraná (SP, PR e MS), composta por depósitos coluviais originados a partir de unidades litoestratigráficas cretáceas da Bacia do Paraná. Os depósitos sedimentares são arenosos, inconsolidados, de coloração vermelho-acastanhada, homogêneos e maciços, comumente confundidos com solos e formações superficiais. Para o estabelecimento de seções de referência de subsuperfície para a Aloformação Paranavaí, foram obtidos testemunhos de sondagem em duas regiões no oeste paulista. Foi conduzido um estudo com diversos parâmetros (texturais, mineralógicos, geoquímicos, isotópicos e geocronológicos) nos sedimentos da Aloformação Paranavaí e do Grupo Bauru. Foram estabelecidas duas novas seções de referência para completar o estratótipo-de-unidade composto estabelecido: seção de referência Rancharia (idades luminescentes entre 71.650 ± 9.000 a 557.000 ± 65.000 AP) e seção de referência Oriente (83.000 ± 8.500 a 436 ± 53.000 anos AP). Idades luminescentes obtidas são crescentes de acordo com a profundidade da Aloformação Paranavaí, enquanto que os sedimentos do Grupo Bauru apresentam idades superiores ao alcance do método geocronológico empregado. Os dados obtidos nas seções de referência apresentam variabilidade em padrões de diversos parâmetros, comprovando diferentes gerações de deposição coluvial ao longo do Quaternário, no oeste paulista.The Paranavaí Alloformation is a Quaternary geological formation found in the Upper Paraná River Hydrographic Basin (states of São Paulo, Paraná and Mato Grosso do Sul), composed of colluvial deposits originated from the Cretaceous lithostratigraphic units of the Paraná Basin. The sedimentary deposits are reddish brown in color, sandy, non-consolidated, homogeneous, massive, and commonly confused with surface soils and formations. In order to obtain subsurface reference sections for the Paranavaí Alloformation, core samples were collected in two regions of the western part of the state of São Paulo. The study was conducted involving several parameters (textural, mineralogical, geochemical, isotopic and geochronological) of the sediments of the Paranavaí Alloformation and Bauru Group. Two new reference sections were obtained in order to establish the composite-stratotype of its constituent formations: Rancharia reference section (luminescence ages between 71650 ± 9000 and 557000 ± 65000 years BP) and Oriente reference section (luminescence ages between 83000 ± 8500 and 436 ± 53000 years BP). The luminescent ages obtained in this study increase according to the depth of the Paranavaí Alloformation, whereas the sediments of the Bauru Group have ages greater than the maximum limit of the geochronological method used. The information obtained from the reference sections shows variability in the patterns of various parameters, proving there were different generations of colluvial deposition throughout the Quaternary period in the western part of the state of São Paulo

Subsurface Reference Sections of the Paranavaí Alloformation

The Paranavaí Alloformation is a Quaternary geological formation found in the Upper Paraná River HydrographicBasin (states of São Paulo, Paraná and Mato Grosso do Sul), composed of colluvial deposits originated from the Cretaceouslithostratigraphic units of the Paraná Basin. The sedimentary deposits are reddish brown in color, sandy, non-consolidated,homogeneous, massive, and commonly confused with surface soils and formations. In order to obtain subsurface referencesections for the Paranavaí Alloformation, core samples were collected in two regions of the western part of the stateof São Paulo. The study was conducted involving several parameters (textural, mineralogical, geochemical, isotopicand geochronological) of the sediments of the Paranavaí Alloformation and Bauru Group. Two new reference sectionswere obtained in order to establish the composite-stratotype of its constituent formations: Rancharia reference section(luminescence ages between 71650 ± 9000 and 557000 ± 65000 years BP) and Oriente reference section (luminescenceages between 83000 ± 8500 and 436 ± 53000 years BP). The luminescent ages obtained in this study increase according ocorritothe depth of the Paranavaí Alloformation, whereas the sediments of the Bauru Group have ages greater than the maximum limit ofthe geochronological method used. The information obtained from the reference sections shows variability in the patterns of variousparameters, proving there were different generations of colluvial deposition throughout the Quaternary period in the western part ofthe state of São Paulo