51 research outputs found

    A rapid screening, “combinatorial-type” survey of the metalloligand chemistry of Pt₂(PPh₃)₄(ÎŒ-S)₂ using electrospray mass spectrometry

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    Electrospray mass spectrometry is a rapid and powerful technique for a combinatorial-like survey of the chemistry of the metalloligand Pt₂(PPh₃)₄(ÎŒ-S)₂, leading to the successful isolation and crystallographic characterisation of the novel protonated species Pt₂(PPh₃)₄(ÎŒ-S)(ÎŒ-SH) together with a range of metallated derivatives

    Investigating hookworm genomes by comparative analysis of two Ancylostoma species

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    Background Hookworms, infecting over one billion people, are the mostly closely related major human parasites to the model nematode Caenorhabditis elegans. Applying genomics techniques to these species, we analyzed 3,840 and 3,149 genes from Ancylostoma caninum and A. ceylanicum. Results Transcripts originated from libraries representing infective L3 larva, stimulated L3, arrested L3, and adults. Most genes are represented in single stages including abundant transcripts like hsp-20 in infective L3 and vit-3 in adults. Over 80% of the genes have homologs in C. elegans, and nearly 30% of these were with observable RNA interference phenotypes. Homologies were identified to nematode-specific and clade V specific gene families. To study the evolution of hookworm genes, 574 A. caninum / A. ceylanicum orthologs were identified, all of which were found to be under purifying selection with distribution ratios of nonsynonymous to synonymous amino acid substitutions similar to that reported for C. elegans / C. briggsae orthologs. The phylogenetic distance between A. caninum and A. ceylanicum is almost identical to that for C. elegans / C. briggsae. Conclusion The genes discovered should substantially accelerate research toward better understanding of the parasites' basic biology as well as new therapies including vaccines and novel anthelmintics

    A two-mass expanding exact space-time solution

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    In order to understand how locally static configurations around gravitationally bound bodies can be embedded in an expanding universe, we investigate the solutions of general relativity describing a space-time whose spatial sections have the topology of a 3-sphere with two identical masses at the poles. We show that Israel junction conditions imply that two spherically symmetric static regions around the masses cannot be glued together. If one is interested in an exterior solution, this prevents the geometry around the masses to be of the Schwarzschild type and leads to the introduction of a cosmological constant. The study of the extension of the Kottler space-time shows that there exists a non-static solution consisting of two static regions surrounding the masses that match a Kantowski-Sachs expanding region on the cosmological horizon. The comparison with a Swiss-Cheese construction is also discussed.Comment: 15 pages, 5 figures. Replaced to match the published versio

    Do primordial Lithium abundances imply there's no Dark Energy?

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    Explaining the well established observation that the expansion rate of the universe is apparently accelerating is one of the defining scientific problems of our age. Within the standard model of cosmology, the repulsive 'dark energy' supposedly responsible has no explanation at a fundamental level, despite many varied attempts. A further important dilemma in the standard model is the Lithium problem, which is the substantial mismatch between the theoretical prediction for 7-Li from Big Bang Nucleosynthesis and the value that we observe today. This observation is one of the very few we have from along our past worldline as opposed to our past lightcone. By releasing the untested assumption that the universe is homogeneous on very large scales, both apparent acceleration and the Lithium problem can be easily accounted for as different aspects of cosmic inhomogeneity, without causing problems for other cosmological phenomena such as the cosmic microwave background. We illustrate this in the context of a void model.Comment: 14 pages, 4 figures. v2: minor rearrangements in the text, comments and references expanded, results unchange

    Crossing of the w=-1 Barrier in Two-Fluid Viscous Modified Gravity

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    Singularities in the dark energy late universe are discussed, under the assumption that the Lagrangian contains the Einstein term R plus a modified gravity term of the form R^\alpha, where \alpha is a constant. It is found, similarly as in the case of pure Einstein gravity [I. Brevik and O. Gorbunova, Gen. Rel. Grav. 37 (2005), 2039], that the fluid can pass from the quintessence region (w>-1) into the phantom region (w<-1) as a consequence of a bulk viscosity varying with time. It becomes necessary now, however, to allow for a two-fluid model, since the viscosities for the two components vary differently with time. No scalar fields are needed for the description of the passage through the phantom barrier.Comment: 16 pages latex, no figure

    The first decade of web-based sports injury surveillance: Descriptive epidemiology of injuries in US high school girls’ basketball (2005–2006 through 2013–2014) and National Collegiate Athletic Association women’s basketball (2004–2005 through 2013–2014)

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    Context: The advent of Web-based sports injury surveillance via programs such as the High School Reporting Information Online system and the National Collegiate Athletic Association Injury Surveillance Program has aided the acquisition of girls’ and women’s basketball injury data. Objective: To describe the epidemiology of injuries sustained in high school girls’ basketball in the 2005–2006 through 2013–2014 academic years and collegiate women’s basketball in the 2004–2005 through 2013–2014 academic years using Web-based sports injury surveillance. Design: Descriptive epidemiology study. Setting: Online injury surveillance from basketball teams in high school girls (annual average ÂŒ 100) and collegiate women (annual average ÂŒ 57). Patients or Other Participants: Girls’ and women’s basketball players who participated in practices and competitions during the 2005–2006 through 2013–2014 academic years in high school or the 2004–2005 through 2013–2014 academic years in college. Main Outcome Measure(s): Certified athletic trainers collected time-loss (24 hours) injury and exposure data. Injury rates per 1000 athlete-exposures (AEs) were calculated. Injury rate ratios (IRRs) with 95% confidence intervals (CIs) were used to compare injury rates by school size or division, time in season, event type, and competition level. Results: The High School Reporting Information Online system documented 2930 time-loss injuries during 1 609 733 AEs; the National Collegiate Athletic Association Injury Surveillance Program documented 3887 time-loss injuries during 783 600 AEs. The injury rate was higher in college than in high school (4.96 versus 1.82/1000 AEs; IRR ÂŒ 2.73; 95% CI ÂŒ 2.60, 2.86). The injury rate was higher in competitions than in practices for both high school (IRR ÂŒ 3.03; 95% CI ÂŒ 2.82, 3.26) and collegiate (IRR ÂŒ 1.99; 95% CI ÂŒ 1.86, 2.12) players. The most common injuries at both levels were ligament sprains, concussions, and muscle/tendon strains; the majority of injuries affected the ankle, knee, and head/face. These injuries were often caused by contact with another player or a noncontact mechanism. Conclusions: Injury rates were higher in collegiate than in high school athletes and in competitions than in practices. Similarities in distributions of injuries by body parts, specific diagnoses, and mechanisms of injury suggest that both levels may benefit from similar injury-prevention strategies

    The first decade of web-based sports injury surveillance: Descriptive epidemiology of injuries in US high school boys’ basketball (2005–2006 through 2013–2014) and National Collegiate Athletic Association men’s basketball (2004–2005 through 2013–2014)

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    Context: The advent of Web-based sports injury surveillance via programs such as the High School Reporting Information Online system and the National Collegiate Athletic Association Injury Surveillance Program has aided the acquisition of boys’ and men’s basketball injury data. Objective: To describe the epidemiology of injuries sustained in high school boys’ basketball in the 2005–2006 through 2013–2014 academic years and collegiate men’s basketball in the 2004–2005 through 2013–2014 academic years using Web-based sports injury surveillance. Design: Descriptive epidemiology study. Setting: Online injury surveillance from basketball teams of high school boys (annual average ÂŒ 100) and collegiate men (annual average ÂŒ 55). Patients or Other Participants: Boys’ and men’s basketball players who participated in practices and competitions during the 2005–2006 through 2013–2014 academic years in high school or the 2004–2005 through 2013–2014 academic years in college. Main Outcome Measures: Athletic trainers collected time-loss (24 hours) injury and exposure data. Injury rates per 1000 athlete-exposures (AEs) were calculated. Injury rate ratios (IRRs) with 95% confidence intervals (CIs) compared injury rates by school size or division, time in season, event type, and competition level. Results: The High School Reporting Information Online system documented 3056 time-loss injuries during 1 977 480 AEs; the National Collegiate Athletic Association Injury Surveillance Program documented 4607 time-loss injuries during 868 631 AEs. The injury rate was higher for college than for high school (5.30 versus 1.55/1000 AE; IRR ÂŒ 3.43; 95% CI ÂŒ 3.28, 3.59). The injury rate was higher for competitions than for practices in both high school (IRR ÂŒ 2.38; 95% CI ÂŒ 2.22, 2.56) and college (IRR ÂŒ 2.02; 95% CI ÂŒ 1.90, 2.14). The most common injuries at both levels were ligament sprains, muscle/ tendon strains, and concussions; most injuries affected the ankle, knee, and head/face. Injuries were most often caused by contact with another player or noncontact mechanisms. Conclusions: Injury rates were greater among collegiate players compared with high school players and were greater during competitions than practices at both levels. Distributions of injuries by body part, diagnoses, and mechanisms of injury were similar, suggesting that athletes at both levels may benefit from similar injury-prevention strategies

    Black hole solutions in F(R) gravity with conformal anomaly

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    In this paper, we consider F(R)=R+f(R)F(R)=R+f(R) theory instead of Einstein gravity with conformal anomaly and look for its analytical solutions. Depending on the free parameters, one may obtain both uncharged and charged solutions for some classes of F(R)F(R) models. Calculation of Kretschmann scalar shows that there is a singularity located at r=0r=0, which the geometry of uncharged (charged) solution is corresponding to the Schwarzschild (Reissner-Nordstr\"om) singularity. Further, we discuss the viability of our models in details. We show that these models can be stable depending on their parameters and in different epoches of the universe.Comment: 12 pages, one figur

    Agnesi Weighting for the Measure Problem of Cosmology

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    The measure problem of cosmology is how to assign normalized probabilities to observations in a universe so large that it may have many observations occurring at many different spacetime locations. I have previously shown how the Boltzmann brain problem (that observations arising from thermal or quantum fluctuations may dominate over ordinary observations if the universe expands sufficiently and/or lasts long enough) may be ameliorated by volume averaging, but that still leaves problems if the universe lasts too long. Here a solution is proposed for that residual problem by a simple weighting factor 1/(1+t^2) to make the time integral convergent. The resulting Agnesi measure appears to avoid problems other measures may have with vacua of zero or negative cosmological constant.Comment: 26 pages, LaTeX; discussion is added of how Agnesi weighting appears better than other recent measure

    Geometric and thermodynamic properties in Gauss-Bonnet gravity

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    In this paper, the generalized second law (GSL) of thermodynamics and entropy is revisited in the context of cosmological models in Gauss-Bonnet gravity with the boundary of the universe is assumed to be enclosed by the dynamical apparent horizon. The model is best fitted with the observational data for distance modulus. The best fitted geometric and thermodynamic parameters such as equation of state parameter, deceleration parameter and entropy are derived. To link between thermodynamic and geometric parameters, the "entropy rate of change multiplied by the temperature" as a model independent thermodynamic state parameter is also derived. The results show that the model is in good agreement with the observational analysis.Comment: 13 pages, 13 figures, to be published in Astrophysics and Space Sc
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