Assessment of change in prostate volume and shape following surgical resection through co-registration of in-vivo MRI and fresh specimen ex-vivo MRI

International audienc

Effect of some Heterocyclic Synthetic Nitrogen Regulators for Increasing the Efficacy of Urea in Paddy-wheat Crop Rotation

98-101In developing countries urea is the major source of nitrogen, but it is a matter of concern that one-third of urea (30-35%) is only utilized by the plants and the rest two-third (65-70%) is lost by volatilization, denitrification, leaching and absorbed in lower profiles of the soil. Due to this farmers suffer a great economic loss and have to face the polluted environment and contaminated water. This wasteful loss of nitrogen can be controlled to a certain extent by application of some heterocyclic nitrogen regulators like pyrazoles and isoxazoles. The isoxazole regulators can control urea hydrolysis and denitrification, and increase N-uptake and apparent N-recovery by formation of nitrogen complexes in soil which can be easily adsorbed by growing plants. The present investigation was carried out in a IARI farm soil (Typic Haplustept) and urea fortified with different synthetic isoxazole compounds for N-regulation. The study indicated that the test regulators (at 5% of the fertilizer level) significantly retarded the nitrification of soil applied urea. In vitro studies have revealed that whereas 75% soil applied urea-N got converted to nitrate-N within a week's time, the use of test chemicals delayed the urea transformation for 10-14 days to achieve the same level of nitrate-N. These regulators not only increased the dry matter yield by 20-25% over control, but their application along with fertilizer also increased the apparent -N recovery by 20-40% in both paddy and wheat crops. The use of these chemicals was not detrimental to soil health. These nitrification regulators retarded the conversion of ammoniacal-N to nitrate-N without accumulation of nitrite-N, which is supposed to be toxic to the plants

Design and development of a unique drop sensing unit for infusion pump.

In the present set-up the precise assembly of drop sensor unit has three IR-LED/detector pairs placed at different planes across drip chamber to detect the falling drop. The prismatic effects due to drops sticking to the walls in front of one pair of transmitter/detector is compensated by other two pairs. This increases a reliability and dependability of the overall system. The unit can accommodate variable sizes of drip chambers available in the market. Details of the above unit are given and the overall performance improvement due to the present device are also discussed

Preliminary experience with a novel method of three-dimensional co-registration of prostate cancer digital histology and in vivo multiparametric MRI

International audienc

In vivo genotoxicity evaluation of a plant based antiarthritic and anticancer therapeutic agent Boswelic acids in rodents

The genotoxic potential of anti-inflammatory/anti-arthritic and anticancer plant based drug molecule Boswelic acids (BA) was studied by in vivo system. Systematic literature survey revealed that studies on the genotoxicity of BA are not available. Although reports on genotoxicity of Boswellia serrata dry extract and modified 3-O-acetyl-11-keto-b-boswelic acid are available and these studies were conducted in vitro systems. The earlier general toxicity study of BA has been conducted by us, revealed it to be non toxic. The genotoxicity was carried out in Wistar rats using different cytogenetic assay systemabnormalities viz. chromosomal aberrations; sperm morphology, micronuclei and comet assays. Six groups of animals, each comprised of five rats, were taken for each study. Group1-4 received BA at 125,250, 500 and 1000mg/kg p.o., respectively prepared as 2% gum acacia suspension, fifth group received a positive control cyclophosphamide (CP) 40 mg/kg p.o. or metronedazole (MTZ) 130 mg/kg p.o. or mercuric chloride (HgCl2) 0.864 mg/kg p.o. (as per the experiment requirement) whereas the sixth group kept as vehicle control. The results on the bases of the data obtained revealed that BA is quite safe as it did not show any genotoxicity at any dose level up to 1000mg/kg. The positive controls used in different experiments showed highly significant abnormal cytogenetic changes in comparison to the control group