COVAD survey 2 long-term outcomes: unmet need and protocol

Vaccine hesitancy is considered a major barrier to achieving herd immunity against COVID-19. While multiple alternative and synergistic approaches including heterologous vaccination, booster doses, and antiviral drugs have been developed, equitable vaccine uptake remains the foremost strategy to manage pandemic. Although none of the currently approved vaccines are live-attenuated, several reports of disease flares, waning protection, and acute-onset syndromes have emerged as short-term adverse events after vaccination. Hence, scientific literature falls short when discussing potential long-term effects in vulnerable cohorts. The COVAD-2 survey follows on from the baseline COVAD-1 survey with the aim to collect patient-reported data on the long-term safety and tolerability of COVID-19 vaccines in immune modulation. The e-survey has been extensively pilot-tested and validated with translations into multiple languages. Anticipated results will help improve vaccination efforts and reduce the imminent risks of COVID-19 infection, especially in understudied vulnerable groups

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

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Not AvailableEight CMS lines and seven restorers were crossed in a line x tester fashion to elucidate the information on combining ability for achene yield, yield components and oil content and also to know the nature of gene action involved in inheritance ofimportant traits. A total of 56 crosses were evaluated for 9 different quantitative traits. The analysis of variance revealed the existence of a statistically significant difference between the genotypes used in crossing, which confirmed the differences among selected parents. Among the lines, CMS-853A and CMS-852A exhibited significant gca effect for most ofthe characters studied except autogamy (%) and were found to be the best combiners. Likewise, tester EC-601878 was the best combiner for plant height, head diameter, days to 50% flowering, achene yield, autogamy (%), hull content, volume weight and oil content. Twenty-three crosses showed significant positive sca effect for yield. Among the crosses, CMS-103A x EC-601978, CMS-10A x EC-601725, CMS-207AxEC-623023,P-89-1AxEC-623027, CMS-850AxEC-601878 andCMS-853AxEC-623027 exhibited higher positive sca effect for yield. Non additive component of the genetic variance was observed for majority of the traits studied.ICA