Central Santa Catarina coastal dunefields chronology and their relation to relative sea level and climatic changes

During the past decades, there have been contrarian explanations for the formation and stabilization of coastal dunefields: while many authors believe the dunes formation would be enhanced by falling sea level, others argue that a rising or stable sea level context would be favorable. For Brazilian coastal dunefields, the second hypothesis seems to be more consistent with the luminescence ages found so far; however, most of these data were obtained without using the SAR protocol. Another point of concern is the role of climate change in the aeolian system, which is still not very clear. The aim of this paper is to try to clarify these two questions. To this end, five coastal dunefields were selected in central Santa Catarina coast. The remote sensing and dating results allowed the discrimination and mapping of at least four aeolian generations. Their age distribution in relation to the global curve of relative sea level variation during the Late Pleistocene allows us to suggest that the formation of Aeolian dunefields in the coastal context is supported by stable relative sea level. However, relative sea level is not the only determinant for the formation and preservation of the aeolian coastal dunes. Evidences of climatic control indicate that the initiation of dunefields would be favored by periods of less humidity while their stabilization would occur preferably during the periods of rain intensification, connected to monsoon activity

Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men

Context: Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability.Objective: To investigate the genetic regulation of serum E2 and E1 in men.Design, Setting, and Participants: Genome-wide association study in 11,097 men of European origin from nine epidemiological cohorts.Main Outcome Measures: Genetic determinants of serum E2 and E1 levels.Results: Variants in/near CYP19A1 demonstrated the strongest evidence for association with E2, resolving to three independent signals. Two additional independent signals were found on the X chromosome; FAMily with sequence similarity 9, member B (FAM9B), rs5934505 (P = 3.4 × 10-8) and Xq27.3, rs5951794 (P = 3.1 × 10-10). E1 signals were found in CYP19A1 (rs2899472, P = 5.5 × 10-23), in Tripartite motif containing 4 (TRIM4; rs17277546, P = 5.8 × 10-14), and CYP11B1/B2 (rs10093796, P = 1.2 × 10-8). E2 signals in CYP19A1 and FAM9B were associated with bone mineral density (BMD). Mendelian randomization analysis suggested a causal effect of serum E2 on BMD in men. A 1 pg/mL genetically increased E2 was associated with a 0.048 standard deviation increase in lumbar spine BMD (P = 2.8 × 10-12). In men and women combined, CYP19A1 alleles associated with higher E2 levels were associated with lower degrees of insulin resistance.Conclusions: Our findings confirm that CYP19A1 is an important genetic regulator of E2 and E1 levels and strengthen the causal importance of E2 for bone health in men. We also report two independent loci on the X-chromosome for E2, and one locus each in TRIM4 and CYP11B1/B2, for E1

Risk factors for Colles' fracture in men and women: results from the European Prospective Osteoporosis Study

The aim of this study was to determine the contribution of constitutional and lifestyle variables on the subsequent risk of distal forearm (Colles') fracture in a multinational, multicenter, population-prospective study. A total of 15,745 subjects from the European Vertebral Osteoporosis Study, who had completed a baseline questionnaire on lifestyle and constitutional factors, were followed up annually using a validated questionnaire to ascertain the occurrence of new fractures. Risks are expressed as hazard ratios (with 95% confidence intervals) derived from a Cox proportional hazards regression model. The incidence of Colles' fracture was 1.7 and 7.3 per 1000 person years in men and women, respectively. In women delayed menarche, over the age of 15 years, was associated with a modest increased risk [HR 1.5 (range 1.1–2.0)]. Regular walking in that group also increased the risk [HR 1.6 (1.2–2.2)] perhaps reflecting the increased exposure to risk of falling. None of the other factors examined revealed any important influences. The results are broadly in line with the few other published prospective studies suggesting only a modest role for these factors in influencing susceptibility to fracture