Programmable multiport optical circuits in opaque scattering materials

We propose and experimentally verify a method to program the effective transmission matrix of general multiport linear optical circuits in random multiple-scattering materials by phase modulation of incident wavefronts. We demonstrate the power of our method by programming linear optical circuits in white paint layers with 2 inputs and 2 outputs, and 2 inputs and 3 outputs. Using interferometric techniques we verify our ability to program any desired phase relation between the outputs. The method works in a deterministic manner and can be directly applied to existing wavefront-shaping setups without the need of measuring a transmission matrix or to rely on sensitive interference measurements.Comment: 14 pages, 7 figure

Programming balanced optical beam splitters in white paint

Wavefront shaping allows for ultimate control of light propagation in multiple-scattering media by adaptive manipulation of incident waves. We shine two separate wavefront-shaped beams on a layer of dry white paint to create two enhanced output speckle spots of equal intensity. We experimentally confirm by interference measurements that the output speckle spots are almost correlated like the two outputs of an ideal balanced beam splitter. The observed deviations from the phase behavior of an ideal beam splitter are analyzed with a transmission matrix model. Our experiments demonstrate that wavefront shaping in multiple-scattering media can be used to approximate the functionality of linear optical devices with multiple inputs and outputs

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.</p

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3�6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55 of the global rise in mean BMI from 1985 to 2017�and more than 80 in some low- and middle-income regions�was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing�and in some countries reversal�of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories. © 2019, The Author(s)

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol�which is a marker of cardiovascular risk�changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95 credible interval 3.7 million�4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world. © 2020, The Author(s), under exclusive licence to Springer Nature Limited

Programmable multiport optical circuits in opaque scattering materials

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Light control with ordered and disordered nanophotonic media

In this dissertation experimental results are presented on controlling light with nanophotonic media. The first part describes research on forbidden zones of light: frequency gaps in photonic crystals. Polarization-resolved and position-dependent reflectance spectroscopy on silicon two- and three-dimensional photonic crystals revealed broad stop bands with record-high reflectivity exceeding 60%. A general diffraction phenomenon, called sub-Bragg diffraction, has been discovered and explained. Angle-averaged, polarization-resolved and position-dependent spectra reveal a common stop band of up to 16% gap-to-midgap frequency ratio for inverse woodpile photonic crystals, forming a strong experimental signature of the presence of a complete photonic band gap.\ud \ud The second part of this dissertation presents experiments on light propagation near the band edge in GaAs photonic-crystal waveguides. Phase-sensitive near-field microscopy was used to map light propagation with sub-wavelength resolution, revealing periodic field patterns consisting of superpositions of optical Bloch modes. A Bloch mode reconstruction algorithm was tested to extract and study individual Bloch modes. In the slow-light regime, the periodic field patterns are perturbed by Anderson-localized modes that form due to multiple-scattering on intrinsic disorder. A detailed dispersion diagram has been measured for a specific photonic-crystal waveguide. A method was introduced to reconstruct the density of optical states, constituting to the first experimental demonstration of an optical Lifshitz tail. \ud \ud The third part of this dissertation describes experiments towards adaptive quantum optics. A high-rate entangled-photon source was developed based on type-II spontaneous parametric down conversion. Single-photon propagation in multiple-scattering media has been controlled with wavefront shaping. The probability that a photon arrives at a target output speckle spot after propagation through a layer of white paint has been increased 30-fold. Wavefront shaping techniques on classical light have been successfully implemented to use opaque scattering media as a balanced optical beam splitter. This is the first demonstration of a multiple input and output wavefront shaping optimization. This work can be extended to program quantum interference in disordered photonic media in general, forming the outlook of adaptive quantum optics