Study of the Local Interstellar Medium using Pulsar Scintillation

We present here the results from an extensive scintillation study of twenty pulsars in the dispersion measure (DM) range 3 - 35 pc cm^-3 carried out using the Ooty Radio Telescope, to investigate the distribution of ionized material in the local interstellar medium (LISM). Our analysis reveals several anomalies in the scattering strength, which suggest that the distribution of scattering material in the Solar neighborhood is not uniform. Our model suggests the presence of a low density bubble surrounded by a shell of much higher density fluctuations. We are able to put some constraints on geometrical and scattering properties of such a structure, and find it to be morphologically similar to the Local Bubble known from other studies.Comment: 5 pages, 3 figure

Domain walls between gauge theories

Noncommutative U(N) gauge theories at different N may be often thought of as different sectors of a single theory: the U(1) theory possesses a sequence of vacua labeled by an integer parameter N, and the theory in the vicinity of the N-th vacuum coincides with the U(N) noncommutative gauge theory. We construct noncommutative domain walls on fuzzy cylinder, separating vacua with different gauge theories. These domain walls are solutions of BPS equations in gauge theory with an extra term stabilizing the radius of the cylinder. We study properties of the domain walls using adjoint scalar and fundamental fermion fields as probes. We show that the regions on different sides of the wall are not disjoint even in the low energy regime -- there are modes penetrating from one region to the other. We find that the wall supports a chiral fermion zero mode. Also, we study non-BPS solution representing a wall and an antiwall, and show that this solution is unstable. We suggest that the domain walls emerge as solutions of matrix model in large class of pp-wave backgrounds with inhomogeneous field strength. In the M-theory language, the domain walls have an interpretation of a stack of branes of fingerstall shape inserted into a stack of cylindrical branes.Comment: Final version; minor corrections; to appear in Nucl.Phys.

Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice

Hearing relies on the mechanosensory inner and outer hair cells (OHCs) of the organ of Corti, which convert mechanical deflections of their actin-rich stereociliary bundles into electrochemical signals. Several actin-associated proteins are essential for stereocilia formation and maintenance, and their absence leads to deafness. One of the most abundant actin-bundling proteins of stereocilia is plastin 1, but its function has never been directly assessed. Here, we found that plastin 1 knock-out (Pls1 KO) mice have a moderate and progressive form of hearing loss across all frequencies. Auditory hair cells developed normally in Pls1 KO, but in young adult animals, the stereocilia of inner hair cells were reduced in width and length. The stereocilia of OHCs were comparatively less affected; however, they also showed signs of degeneration in ageing mice. The hair bundle stiffness and the acquisition of the electrophysiological properties of hair cells were unaffected by the absence of plastin 1, except for a significant change in the adaptation properties, but not the size of the mechanoelectrical transducer currents. These results show that in contrast to other actin-bundling proteins such as espin, harmonin or Eps8, plastin 1 is dispensable for the initial formation of stereocilia. However, the progressive hearing loss and morphological defects of hair cells in adult Pls1 KO mice point at a specific role for plastin 1 in the preservation of adult stereocilia and optimal hearing. Hence, mutations in the human PLS1 gene may be associated with relatively mild and progressive forms of hearing loss

A Nonparametric Method for the Derivation of α/β Ratios from the Effect of Fractionated Irradiations

Multifractionation isoeffect data are commonly analysed under the assumption that cell survival determines the observed tissue or tumour response, and that it follows a linear-quadratic dose dependence. The analysis is employed to derive the α/β ratios of the linear-quadratic dose dependence, and different methods have been developed for this purpose. A common method uses the so-called Fe plot. A more complex but also more rigorous method has been introduced by Lam et al. (1979). Their method, which is based on numerical optimization procedures, is generalized and somewhat simplified in the present study. Tumour-regrowth data are used to explain the nonparametric procedure which provides α/β ratios without the need to postulate analytical expressions for the relationship between cell survival and regrowth delay

Exponential Metric Fields

The Laser Interferometer Space Antenna (LISA) mission will use advanced technologies to achieve its science goals: the direct detection of gravitational waves, the observation of signals from compact (small and dense) stars as they spiral into black holes, the study of the role of massive black holes in galaxy evolution, the search for gravitational wave emission from the early Universe. The gravitational red-shift, the advance of the perihelion of Mercury, deflection of light and the time delay of radar signals are the classical tests in the first order of General Relativity (GR). However, LISA can possibly test Einstein's theories in the second order and perhaps, it will show some particular feature of non-linearity of gravitational interaction. In the present work we are seeking a method to construct theoretical templates that limit in the first order the tensorial structure of some metric fields, thus the non-linear terms are given by exponential functions of gravitational strength. The Newtonian limit obtained here, in the first order, is equivalent to GR.Comment: Accepted for publication in Astrophysics and Space Science, 17 page

Correlated Hybrid Fluctuations from Inflation with Thermal Dissipation

We investigate the primordial scalar perturbations in the thermal dissipative inflation where the radiation component (thermal bath) persists and the density fluctuations are thermally originated. The perturbation generated in this model is hybrid, i.e. it consists of both adiabatic and isocurvature components. We calculate the fractional power ratio ($S$) and the correlation coefficient ($\cos\Delta$) between the adiabatic and the isocurvature perturbations at the commencing of the radiation regime. Since the adiabatic/isocurvature decomposition of hybrid perturbations generally is gauge-dependent at super-horizon scales when there is substantial energy exchange between the inflaton and the thermal bath, we carefully perform a proper decomposition of the perturbations. We find that the adiabatic and the isocurvature perturbations are correlated, even though the fluctuations of the radiation component is considered uncorrelated with that of the inflaton. We also show that both $S$ and $\cos \Delta$ depend mainly on the ratio between the dissipation coefficient $\Gamma$ and the Hubble parameter $H$ during inflation. The correlation is positive ($\cos\Delta > 0$) for strong dissipation cases where $\Gamma/H >0.2$, and is negative for weak dissipation instances where $\Gamma/H <0.2$. Moreover, $S$ and $\cos \Delta$ in this model are not independent of each other. The predicted relation between $S$ and $\cos\Delta$ is consistent with the WMAP observation. Other testable predictions are also discussed.Comment: 18 pages using revtex4, accepted for publication in PR