Biased diffusion in a piecewise linear random potential

We study the biased diffusion of particles moving in one direction under the action of a constant force in the presence of a piecewise linear random potential. Using the overdamped equation of motion, we represent the first and second moments of the particle position as inverse Laplace transforms. By applying to these transforms the ordinary and the modified Tauberian theorem, we determine the short- and long-time behavior of the mean-square displacement of particles. Our results show that while at short times the biased diffusion is always ballistic, at long times it can be either normal or anomalous. We formulate the conditions for normal and anomalous behavior and derive the laws of biased diffusion in both these cases.Comment: 11 pages, 3 figure

Predictive markers of missed miscarriage

The aim of this study was to find useful the serological markers for missed miscarriage (MM) in order to predict the outcome of pregnancy. The study included 141 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were divided into 3 groups. Group 1 included 68 women with MM; Group 2 included 43 women with spontaneous miscarriage; Group 3 included 30 pregnant women without pathology. Proteomic analysis of the blood serum was performed using liquid chromatography-mass spectrometry. The results of our study show that immunoglobulin kappa variable 3-15 (KV315) can be considered as the most promising serologic marker for MM in early gestation. The potential role of KV315 as the serological marker is very important for predicting the course of pregnancy.(International Journal of Biomedicine. 2021;11(1):65-67.). © 2021, International Medical Research and Development Corporation. All rights reserved

Association of Polymorphisms in <i>PPARPGC1A,ACE</i>, and <i>DRD2 G</i>enes with Gestational Diabetes Mellitus

The aim of our research was to study the distribution of polymorphic variants of the DRD2/ANKK1 TaqIA (rs1800497 SNP), PPARGC1A rs8192678 SNP, and ACE I/D in gestational diabetes mellitus (GDM). Methods and Results: The study included 383 pregnant women (gestational age of 37.0-41.0 weeks) with GDM and 68 pregnant women without disturbed carbohydrate metabolism. This was a prospective case-control study. All patients were divided into 3 groups. Group 1 included 211 pregnant women with GDM who received diet therapy only; Group 2 included 172 pregnant women with GDM who received insulin therapy; Group 3 included 68 pregnant women without metabolic disorders. For the DRD2/ANKK1 TaqIA (rs1800497 SNP) (A1/A2; T/C), we found that the TT homozygous genotype and T allele prevailed in Groups with GDM compared with Group without metabolic disorders. Conclusion : A study of the DRD2/ANKK1 TaqIA (rs1800497 SNP), PPARGC1A rs8192678 SNP, and ACE I/D revealed statistically significant increased risks for GDM in carriers of the TT genotype and T allele of the DRD2/ANKK1 TaqIA (rs1800497 SNP)

The results of bacteriological examination in premature infants with neonatal morbidity and mortality

The purpose of this study was to assess the results of bacteriological studies in children born prematurely and compare the received data with the detected neonatal morbidity. Methods and Results: Our study included 227 pregnant women at gestational age of 28-36 weeks 6 days, and their newborns. Depending on the gestational age, they were divided into 3 groups. Group 1 included 73 women at gestational age of 28-30 weeks 6 days; Group 2 included 81 women at gestational age of 31-33 weeks 6 days, Group 3 included 73 women at gestational age of 34-36 weeks 6 days. All women underwent an assessment of vaginal microcenosis and the quantitative and qualitative composition of the biotope of the cervical discharge; the newborns underwent bacteriological examination of the auricle, pharynx and anus. Analysis of the results of bacteriological studies shows a significant growth of microorganisms in newborns from mothers of Group 1. The analysis of morbidity among premature infants showed that in each group there were 2 or 3 diseases, mainly of an infectious nature. The main proportion of morbidity (congenital pneumonia and infections of the perinatal period, diseases of the urinary system, neonatal jaundice of premature infants and cerebral ischemia) among newborns was found in Group 1, compared with Groups 2 and 3. The analysis of the results obtained showed that the low birth weight in preterm labor correlated with the growth of Staphylococcus epidermidis in the throat of newborns. Neonatal jaundice of premature newborns was characterized by 100% detection of Staphylococcus epidermidis and Serratia odorifera in the anus swabs, and Staphylococcus epidermidis in swabs from the pharynx and ear. Congenital pneumonia positively correlated with the growth of Staphylococcus epidermidis, E. coli, Candida spp, Enterococcus faecalis in the throat swab. The deceased children had a co-infection. Conclusion: Our study identified the main microorganisms affecting both perinatal morbidity and neonatal mortality: Staphylococcus epidermidis, Enterococcus faecalis, E. coli, Candida spp. It is necessary to note the frequent identification of E. coli strains resistant to the main antibacterial drugs. © 2020, International Medical Research and Development Corporation. All rights reserved

Association of polymorphisms in PPARPGC1A, ACE, and DRD2 genes with gestational diabetes mellitus

The aim of our research was to study the distribution of polymorphic variants of the DRD2/ANKK1 TaqIA (rs1800497 SNP), PPARGC1A rs8192678 SNP, and ACE I/D in gestational diabetes mellitus (GDM). Methods and Results: The study included 383 pregnant women (gestational age of 37.0–41.0 weeks) with GDM and 68 pregnant women without disturbed carbohydrate metabolism. This was a prospective case-control study. All patients were divided into 3 groups. Group 1 included 211 pregnant women with GDM who received diet therapy only; Group 2 included 172 pregnant women with GDM who received insulin therapy; Group 3 included 68 pregnant women without metabolic disorders. For the DRD2/ANKK1 TaqIA (rs1800497 SNP) (A1/A2; T/C), we found that the TT homozygous genotype and T allele prevailed in Groups with GDM compared with Group without metabolic disorders. Conclusion: A study of the DRD2/ANKK1 TaqIA (rs1800497 SNP), PPARGC1A rs8192678 SNP, and ACE I/D revealed statistically significant increased risks for GDM in carriers of the TT genotype and T allele of the DRD2/ANKK1 TaqIA (rs1800497 SNP). © 2021, International Medical Research and Development Corporation. All rights reserved

Dyslipidemia as Predictor of Missed Miscarriage

Background: This study aimed at finding the diagnostic and prognostic possibilities of determining apoC-II, as a serological marker for MM in early gestation. Methods and Results: The study included 182 pregnant women aged between 18 and 45 years at gestational age under 11 weeks. All women were divided into 3 groups. Group 1 included 90 women with MM; Group 2 included 52 women with spontaneous miscarriage; Group 3 included 40 women without pathology (control group). Lipid metabolism disorders were diagnosed according to the Russian national recommendations of the VII revision (the Russian Society of Cardiologists [RSC, 2020]), considering the European recommendations (2019). Proteomic analysis of the blood serum was performed using liquid chromatography-mass spectrometry. Abnormalities in the lipid profile, manifested as isolated hypercholesterolemia, and combined hypercholesterolemia with hypertriglyceridemia, were more common in patients with MM and spontaneous abortions: 62.2% and 59.7% of cases, respectively, which correlates with the identified marker apoC-II in Group 1 and Group 2. Conclusion: ApoC-II can be considered as the most promising serologic marker for MM in the early gestation period for women with dyslipidemia. © 2021, International Medical Research and Development Corporation. All rights reserved

Peculiar properties of pregnancy and childbirth in women with gestational diabetes mellitus depending on body weight

The purpose of this study was to study the particularities of pregnancy in women with gestational diabetes mellitus and methods of delivery depending on body weight. Methods: The study included 366 pregnant women with gestational diabetes mellitus (GDM) who were delivered in the II quarter of 2019 - I quarter of 2020 in the maternity Department of The Moscow city clinical hospital No. 29 of the Moscow Department of health (gestation period – 37.0–41.0 weeks). Results: patients with GDM and obesity had significant weight gain during pregnancy, especially in the 1st and 2nd trimesters. Trimester weight gain in pregnant women with GDM and various degrees of obesity did not differ significantly. Correlation analysis showed that the higher the body weight of a mother with GDM, the higher the incidence of diabetic fetopathy (DF). The rate of delivery by caesarean section was much higher in the groups of patients with GDM and obesity than in normal-weight women with GDM. © 2020 EManuscript Technologies. All rights reserved