651 research outputs found
Medium-chain fatty acids released from polymeric electrospun patches inhibit Candida albicans growth and reduce the biofilm viability
Oral candidiasis is a very common oral condition among susceptible individuals, with the main causative organism being the fungus Candida albicans. Current drug delivery systems to the oral mucosa are often ineffective because of short drug/tissue contact times as well as increased prevalence of drug-resistant Candida strains. We evaluated the potency of saturated fatty acids as antifungal agents and investigated their delivery by novel electrospun mucoadhesive oral patches using agar disk diffusion and biofilm assays. Octanoic (C8) and nonanoic (C9) acids were the most effective at inhibiting C. albicans growth on disk diffusion assays, both in solution or when released from polycaprolactone (PCL) or polyvinylpyrrolidone/RS100 (PVP/RS100) electrospun patches. In contrast, dodecanoic acid (C12) displayed the most potent antifungal activity against pre-existing C. albicans biofilms in solution or when released by PCL or PVP/RS100 patches. Both free and patch-released saturated fatty acids displayed a significant toxicity to wild-type and azole-resistant strains of C. albicans. These data not only provide evidence that certain saturated fatty acids have the potential to be used as antifungal agents but also demonstrate that this therapy could be delivered directly to Candida-infected sites using electrospun mucoadhesive patches, demonstrating a potential new therapeutic approach to treat oral thrush
Data concerning AED registration in the Danish AED Network, and cardiac arrest-related characteristics of OHCAs, including AED coverage and AED accessibility
Quasi-classical Molecular Dynamics Simulations of the Electron Gas: Dynamic properties
Results of quasi-classical molecular dynamics simulations of the quantum
electron gas are reported. Quantum effects corresponding to the Pauli and the
Heisenberg principle are modeled by an effective momentum-dependent
Hamiltonian. The velocity autocorrelation functions and the dynamic structure
factors have been computed. A comparison with theoretical predictions was
performed.Comment: 8 figure
Photoassociation spectroscopy of cold calcium atoms
Photoassociation spectroscopy experiments on 40Ca atoms close to the
dissociation limit 4s4s 1S0 - 4s4p 1P1 are presented. The vibronic spectrum was
measured for detunings of the photoassociation laser ranging from 0.6 GHz to 68
GHz with respect to the atomic resonance. In contrast to previous measurements
the rotational splitting of the vibrational lines was fully resolved. Full
quantum mechanical numerical simulations of the photoassociation spectrum were
performed which allowed us to put constraints on the possible range of the
calcium scattering length to between 50 a_0 and 300 a_0
Fatty Acid Methyl Esters as Biosolvents of Epoxy Resins: A Physicochemical Study
The C8 to C18 fatty acid methyl esters (FAME) have been compared as solvents for two epoxy resin pre-polymers, bisphenol A diglycidyl ether (DGEBA) and triglycidyl paminophenol ether (TGPA). It was found that the solubilization limits vary according to the ester and that methyl caprylate is the best solvent of both resins. To explain these solubility performances, physical and chemical properties of FAME were studied, such as the Hansen parameters, viscosity, binary diffusion coefficient and vaporization enthalpy. Determination of the physicochemical parameters of FAME was carried out by laboratory experimentations and by calculation from bibliographic data. The Hansen parameters of FAME and epoxy resins pre-polymers were theoretically and experimentally determined. The FAME chain length showed a long dependence on the binary diffusion parameters and kinematic viscosity, which are mass and momentum transport properties. Moreover, the vaporization enthalpy of these compounds was directly correlated with the solubilization limits
Renormalized kinetic theory of classical fluids in and out of equilibrium
We present a theory for the construction of renormalized kinetic equations to
describe the dynamics of classical systems of particles in or out of
equilibrium. A closed, self-consistent set of evolution equations is derived
for the single-particle phase-space distribution function , the correlation
function , the retarded and advanced density response
functions to an external potential , and
the associated memory functions . The basis of the theory is an
effective action functional of external potentials that
contains all information about the dynamical properties of the system. In
particular, its functional derivatives generate successively the
single-particle phase-space density and all the correlation and density
response functions, which are coupled through an infinite hierarchy of
evolution equations. Traditional renormalization techniques are then used to
perform the closure of the hierarchy through memory functions. The latter
satisfy functional equations that can be used to devise systematic
approximations. The present formulation can be equally regarded as (i) a
generalization to dynamical problems of the density functional theory of fluids
in equilibrium and (ii) as the classical mechanical counterpart of the theory
of non-equilibrium Green's functions in quantum field theory. It unifies and
encompasses previous results for classical Hamiltonian systems with any initial
conditions. For equilibrium states, the theory reduces to the equilibrium
memory function approach. For non-equilibrium fluids, popular closures (e.g.
Landau, Boltzmann, Lenard-Balescu) are simply recovered and we discuss the
correspondence with the seminal approaches of Martin-Siggia-Rose and of
Rose.and we discuss the correspondence with the seminal approaches of
Martin-Siggia-Rose and of Rose.Comment: 63 pages, 10 figure
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Low temperature setting iron phosphate ceramics as a stabilization and solidification agent for incinerator ash contaminated with transuranic and RCRA metals
Incineration of combustible Mixed Transuranic Waste yields an ash residue that contains oxides of Resource Conservation and Recovery Act (RCRA) and transuranic metals. In order to dispose of this ash safely, it has to be solidified and stabilized to satisfy appropriate requirements for repository disposal. This paper describes a new method for solidification of incinerator ash, using room temperature setting iron phosphate ceramics, and includes fabrication procedures for these waste forms as well as results of the MCC-1 static leach test, XRD analysis, scanning electron microscopy studies and density measurements of the solidified waste form produced
Adaptive cluster expansion for the inverse Ising problem: convergence, algorithm and tests
We present a procedure to solve the inverse Ising problem, that is to find
the interactions between a set of binary variables from the measure of their
equilibrium correlations. The method consists in constructing and selecting
specific clusters of variables, based on their contributions to the
cross-entropy of the Ising model. Small contributions are discarded to avoid
overfitting and to make the computation tractable. The properties of the
cluster expansion and its performances on synthetic data are studied. To make
the implementation easier we give the pseudo-code of the algorithm.Comment: Paper submitted to Journal of Statistical Physic
Dislocation-Mediated Melting: The One-Component Plasma Limit
The melting parameter of a classical one-component plasma is
estimated using a relation between melting temperature, density, shear modulus,
and crystal coordination number that follows from our model of
dislocation-mediated melting. We obtain in good agreement
with the results of numerous Monte-Carlo calculations.Comment: 8 pages, LaTe
Combined CI+MBPT calculations of energy levels and transition amplitudes in Be, Mg, Ca, and Sr
Configuration interaction (CI) calculations in atoms with two valence
electrons, carried out in the V(N-2) Hartree-Fock potential of the core, are
corrected for core-valence interactions using many-body perturbation theory
(MBPT). Two variants of the mixed CI+MBPT theory are described and applied to
obtain energy levels and transition amplitudes for Be, Mg, Ca, and Sr
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