4 research outputs found
Partial characterization and anticoagulant activity of a heterofucan from the brown seaweed Padina gymnospora
Anti-inflammatory Properties Of A Heparin-like Glycosaminoglycan With Reduced Anti-coagulant Activity Isolated From A Marine Shrimp
The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug. © 2008 Elsevier Ltd. All rights reserved.162195889595Fransson, L.A., (1985) Aspinall GO, 3, pp. 337-413. , Orlando F.L. (Ed), Academic PressYoung, E., (2007) Thromb. Res., , 10.1016/j.thromres.2006.10.026Weiler, J.M., Edens, R.E., Linhardt, R.J., Kapelanski, D.P., (1992) J. 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Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells
The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfate from tuna fish show a potent heparin cofactor II activity. A heparan sulfate derived from bovine pancreas has a potent antithrombotic activity in an arterial and venous thrombosis model with a negligible activity upon the serine proteases of the coagulation cascade. It is suggested that the antithrombotic activity of heparin and other antithrombotic agents is due at least in part to their action on endothelial cells stimulating the synthesis of an antithrombotic heparan sulfate