22 research outputs found
Π’Π΅ΡΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ Π³Π΅Π»ΠΈΠΉ-ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π½Π°Ρ ΡΠΌΠ΅ΡΡ Π² Π»Π΅ΡΠ΅Π±Π½ΠΎΠΌ Π°Π»Π³ΠΎΡΠΈΡΠΌΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ Ρ COVID-19
Background. The paper discusses the use of a thermal helium-oxygen mixture (t-ΠΠ΅/Π2 ), a novel technology, in treating patients with the 2019-nCoV acute respiratory disease (COVID-19) who develop life-threatening respiratory failure.
Aim to evaluate the safety and efficacy of t-ΠΠ΅/Π2 inhalation combined with standard therapy in the treatment of acute respiratory failure in patients with COVID-19.
Materials and Methods. This was a single-center, randomized, prospective study of 70 patients with COVID-19. All patients were divided into two groups: in Group 1 (n = 38) patients received t-He/Π2 in addition to the standard COVID-19 treatment; and in Group 2 (n = 32) patients were given the standard treatment in accordance with the Clinical Treatment Guidelines for patients with COVID-19, developed by the Ministry of Health of the Russian Federation. The male/female ratio was 18/20 in Group 1 and 18/14 in Group 2. The mean age of the patients in the study was 53.5 years (43; 62): 56 years (42; 64) in Group 1 and 52 years (43; 66) in Group 2. All patients had computed tomography (CT) signs of lung injury: ground-glass opacities and areas of consolidation. SARS-CoV-2 RNA was detected in 30 Group 1 patients and 28 Group 2 patients. The patients were matched by sex, age, body mass index (BMI), area of pulmonary involvement, and laboratory findings. All patients provided voluntary informed consent to participate in the study and signed a consent form.
Results. Inhalation of thermal helium-oxygen mixture combined with standard therapy did not cause any procedure-related side effects in any of the patients. The following changes were observed in all patients: pO2 /FiO2 , SpO2 , and lymphocyte counts increased, C-reactive protein (CRP) levels decreased, and D-dimer and ferritin levels returned to normal. In Group 1 statistically significant changes in the above-mentioned parameters were seen within three days, while in Group 2 the same changes were observed between Days 7 and 10 of treatment. In Group 1 patients cleared SARS-CoV-2 within 4872 hours after initiation of inhalation, which was confirmed by polymerase chain reaction (PCR), and in Group 2 virus elimination was achieved within 72168 hours.
Conclusion. The addition of inhalation of a thermal gas mixture of helium and oxygen (t-He/Π2 ) to the standard therapy for patients with SARS-CoV-2 infection, CT signs of pneumonia (grades Π‘T2 or CT3), and acute respiratory failure improves gas exchange, contributes to a more rapid virus elimination, and indirectly reduces inflammation.ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅. Π ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΡΠ΅ΡΡ ΠΏΠΎΠΉΠ΄Π΅Ρ ΠΎ Π½ΠΎΠ²ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π³Π΅Π»ΠΈΡ ΠΈ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π° (t-ΠΠ΅/Π2 ) Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π²ΠΈΡΡΡΠ½ΡΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅ΠΌ Π‘OVID-19 Π½Π° ΡΡΠ°ΠΏΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΆΠΈΠ·Π½Π΅ΡΠ³ΡΠΎΠΆΠ°ΡΡΠ΅Π³ΠΎ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ.
Π¦Π΅Π»Ρ ΠΈΠ·ΡΡΠΈΡΡ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ ΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈΠ½Π³Π°Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ t-ΠΠ΅/Π2 Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΎΡΡΡΠΎΠΉ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π‘OVID-19 Π½Π° ΡΠΎΠ½Π΅ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ.
ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΎΠ΄Π½ΠΎΡΠ΅Π½ΡΡΠΎΠ²ΠΎΠ΅ ΡΠ°Π½Π΄ΠΎΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠ»ΠΎ Π²ΠΊΠ»ΡΡΠ΅Π½ΠΎ 70 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ COVID-19. ΠΠ°ΡΠΈΠ΅Π½ΡΡ Π±ΡΠ»ΠΈ ΡΠ°Π·Π΄Π΅Π»Π΅Π½Ρ Π½Π° Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ: Π² ΠΏΠ΅ΡΠ²ΠΎΠΉ (n = 38) Π² ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΠΉ ΠΏΡΠΎΡΠΎΠΊΠΎΠ» Π»Π΅ΡΠ΅Π½ΠΈΡ COVID-19 Π±ΡΠ»Π° Π²ΠΊΠ»ΡΡΠ΅Π½Π° ΡΠ΅ΡΠ°ΠΏΠΈΡ t-ΠΠ΅/Π2 ; Π²ΠΎ Π²ΡΠΎΡΠΎΠΉ (n = 32) ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΡΡΠ°Π½Π΄Π°ΡΡΠ½Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ Π² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΈΠΈ Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΡΠΌΠΈ ΠΠΈΠ½Π·Π΄ΡΠ°Π²Π° Π ΠΎΡΡΠΈΠΈ Π΄Π»Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ COVID. Π ΠΏΠ΅ΡΠ²ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΠΌΡΠΆΡΠΈΠ½Ρ/ΠΆΠ΅Π½ΡΠΈΠ½Ρ 18/20, Π° Π²ΠΎ Π²ΡΠΎΡΠΎΠΉ 18/14. Π‘ΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΎΡΡΠ°Π²Π»ΡΠ» 53,5 Π³ΠΎΠ΄Π° (43 Π³ΠΎΠ΄Π° ΠΌΡΠΆΡΠΈΠ½Ρ; 62 Π³ΠΎΠ΄Π° ΠΆΠ΅Π½ΡΠΈΠ½Ρ), Π² ΠΏΠ΅ΡΠ²ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ 56 Π»Π΅Ρ (42 ΠΈ 64 Π³ΠΎΠ΄Π° ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ), Π²ΠΎ Π²ΡΠΎΡΠΎΠΉ 52 Π³ΠΎΠ΄Π° (43 ΠΈ 66 Π»Π΅Ρ). Π£ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΈΠΌΠ΅Π»ΠΈΡΡ ΠΠ’-ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π»Π΅Π³ΠΊΠΈΡ
ΠΏΠΎ ΡΠΈΠΏΡ ΠΌΠ°ΡΠΎΠ²ΠΎΠ³ΠΎ ΡΡΠ΅ΠΊΠ»Π°, ΡΡΠ°ΡΡΠΊΠΈ ΠΊΠΎΠ½ΡΠΎΠ»ΠΈΠ΄Π°ΡΠΈΠΈ. Π’Π΅ΡΡ Π ΠΠ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ° SARS-CoV-2 ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π² ΠΏΠ΅ΡΠ²ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ Ρ 30 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π²ΠΎ Π²ΡΠΎΡΠΎΠΉ Ρ 28. ΠΠ°ΡΠΈΠ΅Π½ΡΡ ΡΠΎΠΏΠΎΡΡΠ°Π²ΠΈΠΌΡ ΠΏΠΎ ΠΏΠΎΠ»Ρ, Π²ΠΎΠ·ΡΠ°ΡΡΡ, ΠΈΠ½Π΄Π΅ΠΊΡΡ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° (ΠΠΠ’), ΠΏΠ»ΠΎΡΠ°Π΄ΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ Π»Π΅Π³ΠΎΡΠ½ΠΎΠΉ ΠΏΠ°ΡΠ΅Π½Ρ
ΠΈΠΌΡ, Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠΌ Π΄Π°Π½Π½ΡΠΌ. ΠΡΠ΅ΠΌΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ Π±ΡΠ»ΠΎ ΠΏΠΎΠ΄ΠΏΠΈΡΠ°Π½ΠΎ ΠΈΠ½ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ Π΄ΠΎΠ±ΡΠΎΠ²ΠΎΠ»ΡΠ½ΠΎΠ΅ ΡΠΎΠ³Π»Π°ΡΠΈΠ΅ Π½Π° ΡΡΠ°ΡΡΠΈΠ΅ Π² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ.
Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π³Π΅Π»ΠΈΠΉ-ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄Π½ΠΎΠΉ ΡΠΌΠ΅ΡΠΈ Π½Π° ΡΠΎΠ½Π΅ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π½ΠΈ Ρ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΏΠΎΠ±ΠΎΡΠ½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ², ΡΠ²ΡΠ·Π°Π½Π½ΡΡ
Ρ ΠΏΡΠΎΡΠ΅Π΄ΡΡΠΎΠΉ, Π½Π΅ Π²ΡΡΠ²Π»Π΅Π½ΠΎ. Π£ Π²ΡΠ΅Ρ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ: ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ pΠ2 /FiO2, SpO2 ΠΈ ΡΡΠΎΠ²Π½Ρ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ², ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π‘-ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π±Π΅Π»ΠΊΠ°, Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Π΅ΠΉ Π-Π΄ΠΈΠΌΠ΅ΡΠ°, ΡΠ΅ΡΡΠΈΡΠΈΠ½Π°. ΠΡΠΈ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎ ΠΈΠ·ΠΌΠ΅Π½ΠΈΠ»ΠΈΡΡ Π² ΠΏΠ΅ΡΠ²ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 3 ΡΡΡ, ΡΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ Π²ΠΎ Π²ΡΠΎΡΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ Π½Π° 710-Π΅ ΡΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΠ»ΠΈΠΌΠΈΠ½Π°ΡΠΈΡ Π²ΠΈΡΡΡΠ° SARS-CoV-2 Π² ΠΏΠ΅ΡΠ²ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΠ»Π° Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 4872 Ρ ΠΎΡ ΠΌΠΎΠΌΠ΅Π½ΡΠ° Π½Π°ΡΠ°Π»Π° ΠΈΠ½Π³Π°Π»ΡΡΠΈΠΈ, ΡΡΠΎ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π°Π»ΠΎΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΠ¦Π , Π° Π²ΠΎ Π²ΡΠΎΡΠΎΠΉ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 72168 Ρ.
ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΠ½Π³Π°Π»ΡΡΠΈΠΉ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π³Π°Π·ΠΎΠ²ΠΎΠΉ ΡΠΌΠ΅ΡΠΈ Π³Π΅Π»ΠΈΡ Ρ ΠΊΠΈΡΠ»ΠΎΡΠΎΠ΄ΠΎΠΌ (t-ΠΠ΅/Π2 ) Π² ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠ΅ΡΠ΅Π½ΠΎΡΡΡΠΈΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅, Π²ΡΠ·Π²Π°Π½Π½ΠΎΠ΅ SARS-CΠΎV-2, c ΠΠ’-ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠΈ (ΠΠ’2, ΠΠ’3), Ρ ΠΎΡΡΡΠΎΠΉ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡΡ ΡΠ»ΡΡΡΠ°Π΅Ρ Π³Π°Π·ΠΎΠΎΠ±ΠΌΠ΅Π½, ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ ΡΡΠΊΠΎΡΠ΅Π½ΠΈΡ ΡΠ»ΠΈΠΌΠΈΠ½Π°ΡΠΈΠΈ Π²ΠΈΡΡΡΠ° ΠΈ ΠΎΠΏΠΎΡΡΠ΅Π΄ΠΎΠ²Π°Π½Π½ΠΎ ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΡΡΡΠ΅ΠΊΡ
Thermovaccination β thermoheliox as a stimulator of the immune response. Kinetics of the synthesis of antibodies and C-reactive protein in coronavirus infection
Clinical trials of thermoheliox application (inhalation with a high-temperature mixture of oxygen and helium, 90 Β°C) in the treatment of the acute phase of coronavirus infection were conducted. Dynamics of disease development in infected patients (PCR test for the virus) and, dynamics of changes in blood concentration of C-reactive protein, immunoglobulin M, specific immunoglobulin G were studied. High efficiency of thermoheliox in releasing the organism from the virus and stimulating the immune response (thermovaccination effect) was shown. The kinetic model of the process is proposed and analyzed. Β© 2020 Elsevier B.V
Chemical kinetics of the development of coronaviral infection in the human body: Critical conditions, toxicity mechanisms, βthermohelioxβ, and βthermovaccinationβ
Kinetic modeling of the behavior of complex chemical and biochemical systems is an effective approach to study of the mechanisms of the process. A kinetic model of coronaviral infection development with a description of the dynamic behavior of the main variables, including the concentration of viral particles, affected cells, and pathogenic microflora, is proposed. Changes in the concentration of hydrogen ions in the lungs and the pH -dependence of carbonic anhydrase activity (a key breathing enzyme) are critical. A significant result is the demonstration of an acute bifurcation transition that determines life or system collapse. This transition is connected with exponential growth of concentrations of the process participants and with functioning of the key enzyme carbonic anhydrase in development of toxic effects. Physical and chemical interpretations of the therapeutic effects of the body temperature rise and the potential therapeutic effect of βthermohelioxβ (respiration with a thermolized mixture of helium and oxygen) are given. The phenomenon of βthermovaccinationβ is predicted, which involves stimulation of the immune response by βthermohelioxβ. Β© 2020 Elsevier B.V