Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.</p

Repositioning of the global epicentre of non-optimal cholesterol

High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol�which is a marker of cardiovascular risk�changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95 credible interval 3.7 million�4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world. © 2020, The Author(s), under exclusive licence to Springer Nature Limited

Evidence for late-glacial ice dammed lakes in the central Strait of Magellan and Bahia Inutil, southernmost South America

This paper critically appraises the evidence for a succession of ice-dammed lakes in the central Strait of Magellan (c. 53&deg;S) c. 17 000-12 250 cal. yr BP. The topographic configuration of islands and channels in the southern Strait of Magellan means that the presence of lakes provides compelling constraints on the position of former ice margins. Lake shorelines and glacio-lacustrine sediments have been dated by their association with a key tephra layer from Volcan Recl&uacute;s (c. 15 510-14 350 cal. years bp) and by 14C-dated peats. The timing of glacial lake formation and associated glacier readvances is at odds with the rapid and widespread glacier retreat of the Patagonian ice fields further north after c. 17 000 cal. yr bp, suggesting rather that the lakes were coeval with the Antarctic Cold Reversal and persisted to the Late-glacial/Holocene transition. This apparent asymmetrical latitudinal response in glacier behaviour may reflect overlapping spheres of northern hemisphere and Antarctic climatic influence in the Magellan region

Design drivers for a wide-field multi-object spectrograph for the William Herschel Telescope

Original article can be found at: http://spiedigitallibrary.aip.org/browse/vol_range.jsp. COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only. [Full text of this paper is not available in the UHRA]Wide-field multi-object spectroscopy is a high priority for European astronomy over the next decade. Most 8-10m telescopes have a small field of view, making 4-m class telescopes a particularly attractive option for wide-field instruments. We present a science case and design drivers for a wide-field multi-object spectrograph (MOS) with integral field units for the 4.2-m William Herschel Telescope (WHT) on La Palma. The instrument intends to take advantage of a future prime-focus corrector and atmospheric-dispersion corrector (Agocs et al, this conf.) that will deliver a field of view 2 deg in diameter, with good throughput from 370 to 1,000 nm. The science programs cluster into three groups needing three different resolving powers R: (1) high-precision radial-velocities for Gaia-related Milky Way dynamics, cosmological redshift surveys, and galaxy evolution studies (R = 5,000), (2) galaxy disk velocity dispersions (R = 10,000) and (3) high-precision stellar element abundances for Milky Way archaeology (R = 20,000). The multiplex requirements of the different science cases range from a few hundred to a few thousand, and a range of fibre-positioner technologies are considered. Several options for the spectrograph are discussed, building in part on published design studies for E-ELT spectrographs. Indeed, a WHT MOS will not only efficiently deliver data for exploitation of important imaging surveys planned for the coming decade, but will also serve as a test-bed to optimize the design of MOS instruments for the future E-ELT.Peer reviewe