Characterizations on microencapsulated sunflower oil as self-healing agent using In situ polymerization method

This paper emphasizes the characterization on the microencapsulation of sunflower oil as self-healing agent. In-situ polymerization method mainly implicates in the microencapsulation process. The analysis of microencapsulated sunflower oil via prominent characterization of yield of microcapsules, microcapsules characteristics and Fourier Transmission Infa-Red Spectroscopy (FTIR). The prime optimization used was reaction time of microencapsulation process in the ranges of 2, 3 and 4 h. The higher reaction time of microencapsulation process resulted in a higher yield of microcapsules. The yield of microcapsules increases from 46 to 53% respectively by the increasing of reaction time from 2 to 4 h. The surface morphology study associating the diameter of microcapsules measured to analyse the prepared microcapsules. It was indicated that microcapsules were round in shape with smooth micro-surfaces. It was discovered that the diameter of microcapsules during microencapsulation process after 4 h reaction time was in average of 70.53 μm. This size was measured before filtering the microcapsules with solvent and dried in vacuum oven. Apparently, after filtering and drying stage, the diameter of microcapsules specifically identified under Field Emission Scanning Electron Microscopy (FESEM) showing the size of 2.33 μm may be due to the removing the suspended oil surrounded the microcapsules. Sunflower oil as core content and urea formaldehyde (UF) as shell of microcapsules demonstrated the proven chemical properties on characterization by FTIR with the stretching peak of 1537.99 - 1538.90 cm-1 (-H in -CH2), 1235.49 - 1238.77 cm-1 (C-O-C Vibrations at Ester) and 1017.65 - 1034.11 cm-1 (C-OH Stretching Vibrations). It was showed that sunflower oil can be considered as an alternative nature resource for self-healing agent in microencapsulation process. The characterization of microencapsulated sunflower oil using in-situ polymerization method showed that sunflower oil was viable self-healing agent to be encapsulated and incorporated in metal coating

Cost-Effectiveness of Clinical Pharmacy Education on Infection Management among Patients with Chronic Kidney Disease in an Indonesian Hospital

AbstractObjectivesThis study evaluated the clinical and economic impacts of clinical pharmacy education (CPE) on infection management among patients with chronic kidney disease (CKD) stages 4 and 5 in Haji Adam Malik Hospital, Indonesia.MethodsA quasi-experimental economic evaluation comparing CPE impact on 6-month CKD mortality was conducted on the basis of payer perspective. The experimental group (n = 63) received care by health care providers who were given CPE on drug-related problems and dose adjustment. The control group (n = 80) was based on the historical cohort of patients who received care before the CPE. Measure of clinical outcome applied in this study was number of lives saved/100 patients treated. Cost-effectiveness ratios for CKD stages 4 and 5 patients without CPE and with CPE and incremental cost-effectiveness ratios (ICERs) for CKD stages 4 and 5 patients were analyzed.ResultsLives saved (%) in the treatment of CKD without CPE: CKD stage 4, 78.57; CKD stage 5, 57.58. Lives saved (%) in the treatment of CKD with CPE: CKD stage 4, 88.89; CKD stage 5, 65.45. Cost-effectiveness ratios for stage 4 with and without CPEs were Rp3,348,733.27 and Rp3,519,931.009, respectively. Cost-effectiveness ratios for stage 5 with and without CPEs were Rp7,137,874.93 and Rp7,871,822.27, respectively. ICERs were Rp2,045,341.22 for CKD stage 4 and Rp1,767,585.60 for CKD stage 5.ConclusionsTreatment of CKD stages 4 and 5 with CPE was more effective and cost-effective compared with treatment of CKD stages 4 and 5 without CPE. The ICERs indicated that extra costs were required to increase life saved in both stages

Analysis awkward posture at food production activity using RULA assessment

If the workers continuously perform the activities throughout the working hours, they may experience prolonged standing which creates fatigue and causes an occupational hazard which includes slips and falls. The goal of this study was to identify awkward postures during food production activities. 40 workers with minimum of 1 year experience working in food production were involved. The comfort level was measured using Rapid Upper Limb Assessment and Computer-Aided Three-Dimensional Interactive Application software analysis, expressed in scoring level. Critical activities grilling meat, frying, dish cloth and wash utensil at food production contributed to high RULA score of 7. The specific working postures have to be identified among food production workers. This study can provide a preliminary data to determine the correct working postures for food production workers.Keywords: working position; food production; awkward posture; RULA score, fatigue and standin

Characteristics of Trypsin-like Activity in Subgingival Plaque Samples

Previous studies have demonstrated that the hydrolysis of the trypsin substrate N-benzoyl-DL-arginine-2-naphthylamide (BANA), by subgingival plaque obtained from a single site, correlates best with the numbers and proportions of spirochetes in plaque samples and may serve as an indicator of clinical disease. In this investigation, we determined whether the association between BANA hydrolysis and spirochetes could be obtained in pooled subgingival plaque samples. Concomitantly, the characteristics of this reaction in terms of substrate type and concentration, microbial numbers needed to give a positive reaction as assessed by microscopic counts, rapidity of hydrolysis, and the effect of pH and various additives on the plaque BANA hydrolytic activity have been studied in pooled plaque samples from patients who were periodontally healthy or diseased. In addition, it was determined whether BANA hydrolytic activity found in subgingival plaque reflected contributions from saliva and supragingival plaque. Results indicated that the assay can best be performed with 0.67 mmol/L BANA at pH 7.0. EDTA and CaCl2 gave a slight inhibition and DTT a slight enhancement of the BANA reaction by the pooled plaque suspensions. The majority of the reactions (85%) developed their full color after overnight incubation. BANA hydrolysis was not found in saliva and occurred with much greater frequency in subgingival plaque as opposed to supragingival plaque. Analysis of the data indicated that BANA hydrolysis by pooled subgingival plaque samples is a suitable test for the detection of spirochetes when two or three spirochetes per high microscopic field are present in the sample.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67374/2/10.1177_00220345870660111301.pd

Political Economy of Conflict: The Social Contract and Conflict in Pakistan

The main concern of this thesis is to analyze conflict in Pakistan, mainly the ethnopolitical conflict. It builds a case that conflict in Pakistan has been a product of the weakening of its social contract. This is both a qualitative and quantitative work which relies on both primary and secondary data as well as diverse techniques from historical interpretative analysis to econometrics. In addition to the ethnopolitical conflict, the thesis also contains an analysis of the factors leading to taliban recruitment in the current conflict. The thesis attempts to link the historical evolution and composition of social contract and the struggles over identity in pre and post independence era of Pakistan. It sets up a theoretical framework which defines the relevant concepts of identity, ethnopolitics, conflict, social contract, institutions and the saliency of socio economic determinants of conflict. To test this theoretical framework, an analytical framework is proposed which operationalizes these concepts. Data about the violent and non violent ethnopolitical conflict from 1972 to 2005 is collected, coded and put into a data scheme which helps us build the composite and individual pictures of this conflict through time. This database is unique to the extent of Pakistan. The thesis finds that the intensity of the major individual conflict have mostly followed an inverted U curve through time. Except for Balochistan, this is true for both the violent as well as non violent conflict. The emerging conflict is then explained with the help of the decay of institutions of conflict management. These include both the formal and informal types. Two political and two economic institutions are selected for analysis which are part of the fiscal federalist scheme of the constitution. The findings suggest that consociational federalism has worked to bring down the intensity of conflict among the federating units. To investigate the political power dynamics, an original scheme of quantifying the political power gap in the state structure is employed and the emerging picture is then contrasted with the picture of ethnopolitical conflict. Analysis also suggests that democracies have worked better at containing the conflict inside the institutions that were created for its management. The thesis takes up the saliency of the debate about the social and political horizontal inequalities, especially in Pakistani context and follows it with an econometric analysis of the data related to these inequalities and conflict. Linking grievances with the socio economic and political horizontal inequalities among federating units, the econometric results suggest that overall, larger inequalities led towards greater ethnopolitical

Validation of a method for diosgenin extraction from fenugreek (Trigonella foenum-graecum L.)

Background. Diosgenin is a very important plant secondary metabolite and raw material for the drug industry. Plant sources rich in diosgenin include yam (Dioscorea spp.) and fenugreek (Trigonella foenum-graecum L.). A method for diosgenin extraction from yam extracts has previously been validated, but its extraction from fenugreek plants still requires validation. In addition, all available methods require time-consuming additional purification steps. The present study was aimed at developing a low cost, less time-consuming single-step method for diosgenin extraction from fenugreek. Material and methods. This study represents a method developed for diosgenin extraction from fenugreek plants without any additional/supportive purification methods such as chromatography or thin-layer chromatography. Diosgenin yield estimation and purity analysis by HPLC method, along with accuracy and precision analysis, is presented. Results. Five different fenugreek varieties were subjected to a newly developed diosgenin extraction method, and an HPLC chromatogram showed a single peak corresponding to diosgenin. Yield was determined by the standard curve method. Limit of detection (LOD) and limit of quantification (LOQ) for the assay were found to be 0.0312 and 0.102 \u3bcg, respectively; t calculated for slope and other statistical parameters were found to be significant (P value < 0.001) for this method. Conclusion. We have developed a fast, accurate and low cost method for diosgenin extraction from fenugreek. Although the authors have studied this method only in fenugreek plants, it could be applied to the extraction of a few other plant secondary metabolites, which will help researchers to save time and effort