Semiclassical Strings, Dipole Deformations of N=1 SYM and Decoupling of KK Modes

In this paper we investigate the recently found $\gamma$-deformed Maldacena-Nunez background by studying the behavior of different semiclassical string configurations. This background is conjectured to be dual to dipole deformations of $\N=1$ SYM. We compare our results to those in the pure Maldacena-Nunez background and show that the energies of our string configurations are higher than in the undeformed background. Thinking in the lines of (hep-th/0505100) we argue that this is an evidence for better decoupling of the Kaluza-Klein modes from the pure SYM theory excitations. Moreover we are able to find a limit of the background in which the string energy is independent of $\gamma$, these strings are interpreted as corresponding to pure gauge theory effects.Comment: 31 pages, references added, new solutions in Section 7 presented, an appendix added, to appear in JHE

The scaling function at strong coupling from the quantum string Bethe equations

We study at strong coupling the scaling function describing the large spin anomalous dimension of twist two operators in ${\cal N}=4$ super Yang-Mills theory. In the spirit of AdS/CFT duality, it is possible to extract it from the string Bethe Ansatz equations in the $\mathfrak{sl}(2)$ sector of the \ads superstring. To this aim, we present a detailed analysis of the Bethe equations by numerical and analytical methods. We recover several short string semiclassical results as a check. In the more difficult case of the long string limit providing the scaling function, we analyze the strong coupling version of the Eden-Staudacher equation, including the Arutyunov-Frolov-Staudacher phase. We prove that it admits a unique solution, at least in perturbation theory, leading to the correct prediction consistent with semiclassical string calculations.Comment: 25 pages, 5 eps figure

Integrable twists in AdS/CFT

A class of marginal deformations of four-dimensional N=4 super Yang-Mills theory has been found to correspond to a set of smooth, multiparameter deformations of the S^5 target subspace in the holographic dual on AdS_5 x S^5. We present here an analogous set of deformations that act on global toroidal isometries in the AdS_5 subspace. Remarkably, certain sectors of the string theory remain classically integrable in this larger class of so-called gamma-deformed AdS_5 x S^5 backgrounds. Relying on studies of deformed su(2)_gamma models, we formulate a local sl(2)_gamma Lax representation that admits a classical, thermodynamic Bethe equation (based on the Riemann-Hilbert interpretation of Bethe's ansatz) encoding the spectrum in the deformed AdS_5 geometry. This result is extended to a set of discretized, asymptotic Bethe equations for the twisted string theory. Near-pp-wave energy spectra within sl(2)_gamma and su(2)_gamma sectors provide a useful and stringent test of such equations, demonstrating the reliability of this technology in a wider class of string backgrounds. In addition, we study a twisted Hubbard model that yields certain predictions of the dual beta-deformed gauge theory.Comment: v2: references and clarifications added, 46 page

Strange Stars with a Density-Dependent Bag Parameter

We have studied strange quark stars in the framework of the MIT bag model, allowing the bag parameter B to depend on the density of the medium. We have also studied the effect of Cooper pairing among quarks, on the stellar structure. Comparison of these two effects shows that the former is generally more significant. We studied the resulting equation of state of the quark matter, stellar mass-radius relation, mass-central-density relation, radius-central-density relation, and the variation of the density as a function of the distance from the centre of the star. We found that the density-dependent B allows stars with larger masses and radii, due to stiffening of the equation of state. Interestingly, certain stellar configurations are found to be possible only if B depends on the density. We have also studied the effect of variation of the superconducting gap parameter on our results.Comment: 23 pages, 8 figs; v2: 25 pages, 9 figs, version to be published in Phys. Rev. (D

Review of AdS/CFT Integrability, Chapter II.2: Quantum Strings in AdS5xS5

We review the semiclassical analysis of strings in AdS5xS5 with a focus on the relationship to the underlying integrable structures. We discuss the perturbative calculation of energies for strings with large charges, using the folded string spinning in an AdS3 subset of AdS5 as our main example. Furthermore, we review the perturbative light-cone quantization of the string theory and the calculation of the worldsheet S-matrix.Comment: 20 pages, see also overview article arXiv:1012.3982, v2: references to other chapters update

Green-Schwarz Strings in TsT-transformed backgrounds

We consider classical strings propagating in a background generated by a sequence of TsT transformations. We describe a general procedure to derive the Green-Schwarz action for strings. We show that the U(1) isometry variables of the TsT-transformed background are related to the isometry variables of the initial background in a universal way independent of the details of the background. This allows us to prove that strings in the TsT-transformed background are described by the Green-Schwarz action for strings in the initial background subject to twisted boundary conditions. Our construction implies that a TsT transformation preserves integrability properties of the string sigma model. We discuss in detail type IIB strings propagating in the \g_i-deformed AdS_5 x S^5 space-time, find the twisted boundary conditions for bosons and fermions, and use them to write down an explicit expression for the monodromy matrix. We also discuss string zero modes whose dynamics is governed by a fermionicgeneralization of the integrable Neumann model.Comment: 33 pages, latex, v2: typos correcte

The check of QCD based on the tau-decay data analysis in the complex q^2-plane

The thorough analysis of the ALEPH data on hadronic tau-decay is performed in the framework of QCD. The perturbative calculations are performed in 3 and 4-loop approximations. The terms of the operator product expansion (OPE) are accounted up to dimension D=8. The value of the QCD coupling constant alpha_s(m_tau^2)=0.355 pm 0.025 was found from hadronic branching ratio R_tau. The V+A and V spectral function are analyzed using analytical properties of polarization operators in the whole complex q^2-plane. Borel sum rules in the complex q^2 plane along the rays, starting from the origin, are used. It was demonstrated that QCD with OPE terms is in agreement with the data for the coupling constant close to the lower error edge alpha_s(m_tau^2)=0.330. The restriction on the value of the gluonic condensate was found =0.006 pm 0.012 GeV^2. The analytical perturbative QCD was compared with the data. It is demonstrated to be in strong contradiction with experiment. The restrictions on the renormalon contribution were found. The instanton contributions to the polarization operator are analyzed in various sum rules. In Borel transformation they appear to be small, but not in spectral moments sum rules.Comment: 24 pages; 1 latex + 13 figure files. V2: misprints are corrected, uncertainty in alpha_s is explained in more transparent way, acknowledgement is adde

IL11 activates pancreatic stellate cells and causes pancreatic inflammation, fibrosis and atrophy in a mouse model of pancreatitis

Interleukin-11 (IL11) is important for fibrosis and inflammation, but its role in the pancreas is unclear. In pancreatitis, fibrosis, inflammation and organ dysfunction are associated with pancreatic stellate cell (PSC)-to-myofibroblast transformation. Here, we show that IL11 stimulation of PSCs, which specifically express IL11RA in the pancreas, results in transient STAT3 phosphorylation, sustained ERK activation and PSC activation. In contrast, IL6 stimulation of PSCs caused sustained STAT3 phosphorylation but did not result in ERK activation or PSC transformation. Pancreatitis factors, including TGFβ, CTGF and PDGF, induced IL11 secretion from PSCs and a neutralising IL11RA antibody prevented PSC activation by these stimuli. This revealed an important ERK-dependent role for autocrine IL11 activity in PSCs. In mice, IL11 was increased in the pancreas after pancreatic duct ligation, and in humans, IL11 and IL11RA levels were elevated in chronic pancreatitis. Following pancreatic duct ligation, administration of anti-IL11RA to mice reduced pathologic (ERK, STAT, NF-κB) signalling, pancreatic atrophy, fibrosis and pro-inflammatory cytokine (TNFα, IL6 and IL1β) levels. This is the first description of IL11-mediated activation of PSCs, and the data suggest IL11 as a stromal therapeutic target in pancreatitis

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

The kidney has large regenerative capacity, but this is compromised when kidney damage is excessive and renal tubular epithelial cells (TECs) undergo SNAI1-driven growth arrest. Here we investigate the role of IL11 in TECs, kidney injury and renal repair. IL11 stimulation of TECs induces ERK- and p90RSK-mediated GSK3β inactivation, SNAI1 upregulation and pro-inflammatory gene expression. Mice with acute kidney injury upregulate IL11 in TECs leading to SNAI1 expression and kidney dysfunction, which is not seen in Il11 deleted mice or in mice administered a neutralizing IL11 antibody in either preemptive or treatment modes. In acute kidney injury, anti-TGFβ reduces renal fibrosis but exacerbates inflammation and tubule damage whereas anti-IL11 reduces all pathologies. Mice with TEC-specific deletion of Il11ra1 have reduced pathogenic signaling and are protected from renal injury-induced inflammation, fibrosis, and failure. In a model of chronic kidney disease, anti-IL11 therapy promotes TEC proliferation and parenchymal regeneration, reverses fibroinflammation and restores renal mass and function. These data highlight IL11-induced mesenchymal transition of injured TECs as an important renal pathology and suggest IL11 as a therapeutic target for restoring stalled endogenous regeneration in the diseased kidney

Charge-Dependent Correlations in Relativistic Heavy Ion Collisions and the Chiral Magnetic Effect

We provide a phenomenological analysis of present experimental searches for local parity violation manifested through the Chiral Magnetic Effect. We introduce and discuss the relevant correlation functions used for the measurements. Our analysis of the available data from both RHIC and LHC shows that the present experimental evidence for the Chiral Magnetic Effect is rather ambiguous. We further discuss in some detail various background contributions due to conventional physics, which need to be understood quantitatively in order to draw a definitive conclusion about the existence of local parity violation in heavy ion collisions.Comment: 37 pages, to appear in Lect. Notes Phys. "Strongly interacting matter in magnetic fields" (Springer), edited by D. Kharzeev, K. Landsteiner, A. Schmitt, H.-U. Ye