Recent advances in understanding and managing chronic pelvic pain in women with special consideration to endometriosis

Chronic pelvic pain (CPP) in women is defined variably, but for clinical use it is cyclical or non-cyclical pain of at least 3-6 months' duration. It has major impacts on individuals and society. There are both structural and idiopathic causes. Whereas CPP is not curable in many cases, it is treatable. The most promising approach is multidisciplinary patient-centered care including cause-directed therapy, lifestyle changes, talking therapies, meditation, acupuncture, and physiotherapy (this is not a complete list). One of the most common structural causes for CPP is endometriosis. This review investigates current scientific concepts and recent innovations in this field as well as for CPP in general

Quantum Walks with Entangled Coins

We present a mathematical formalism for the description of unrestricted quantum walks with entangled coins and one walker. The numerical behaviour of such walks is examined when using a Bell state as the initial coin state, two different coin operators, two different shift operators, and one walker. We compare and contrast the performance of these quantum walks with that of a classical random walk consisting of one walker and two maximally correlated coins as well as quantum walks with coins sharing different degrees of entanglement. We illustrate that the behaviour of our walk with entangled coins can be very different in comparison to the usual quantum walk with a single coin. We also demonstrate that simply by changing the shift operator, we can generate widely different distributions. We also compare the behaviour of quantum walks with maximally entangled coins with that of quantum walks with non-entangled coins. Finally, we show that the use of different shift operators on 2 and 3 qubit coins leads to different position probability distributions in 1 and 2 dimensional graphs.Comment: Two new sections and several changes from referees' comments. 12 pages and 12 (colour) figure

Incompatible sets of gradients and metastability

We give a mathematical analysis of a concept of metastability induced by incompatibility. The physical setting is a single parent phase, just about to undergo transformation to a product phase of lower energy density. Under certain conditions of incompatibility of the energy wells of this energy density, we show that the parent phase is metastable in a strong sense, namely it is a local minimizer of the free energy in an $L^1$ neighbourhood of its deformation. The reason behind this result is that, due to the incompatibility of the energy wells, a small nucleus of the product phase is necessarily accompanied by a stressed transition layer whose energetic cost exceeds the energy lowering capacity of the nucleus. We define and characterize incompatible sets of matrices, in terms of which the transition layer estimate at the heart of the proof of metastability is expressed. Finally we discuss connections with experiment and place this concept of metastability in the wider context of recent theoretical and experimental research on metastability and hysteresis.Comment: Archive for Rational Mechanics and Analysis, to appea

UV solar irradiance in observations and the NRLSSI and SATIRE-S models

Total solar irradiance and UV spectral solar irradiance have been monitored since 1978 through a succession of space missions. This is accompanied by the development of models aimed at replicating solar irradiance by relating the variability to solar magnetic activity. The NRLSSI and SATIRE-S models provide the most comprehensive reconstructions of total and spectral solar irradiance over the period of satellite observation currently available. There is persistent controversy between the various measurements and models in terms of the wavelength dependence of the variation over the solar cycle, with repercussions on our understanding of the influence of UV solar irradiance variability on the stratosphere. We review the measurement and modelling of UV solar irradiance variability over the period of satellite observation. The SATIRE-S reconstruction is consistent with spectral solar irradiance observations where they are reliable. It is also supported by an independent, empirical reconstruction of UV spectral solar irradiance based on UARS/SUSIM measurements from an earlier study. The weaker solar cycle variability produced by NRLSSI between 300 and 400 nm is not evident in any available record. We show that although the method employed to construct NRLSSI is principally sound, reconstructed solar cycle variability is detrimentally affected by the uncertainty in the SSI observations it draws upon in the derivation. Based on our findings, we recommend, when choosing between the two models, the use of SATIRE-S for climate studies

Singularity theory study of overdetermination in models for L-H transitions

Two dynamical models that have been proposed to describe transitions between low and high confinement states (L-H transitions) in confined plasmas are analysed using singularity theory and stability theory. It is shown that the stationary-state bifurcation sets have qualitative properties identical to standard normal forms for the pitchfork and transcritical bifurcations. The analysis yields the codimension of the highest-order singularities, from which we find that the unperturbed systems are overdetermined bifurcation problems and derive appropriate universal unfoldings. Questions of mutual equivalence and the character of the state transitions are addressed.Comment: Latex (Revtex) source + 13 small postscript figures. Revised versio

The Semileptonic Decays D→π(ρ)eνD\to \pi(\rho) e \nu and B→π(ρ)eνB\to \pi (\rho) e \nu from QCD Sum Rules

We investigate the semileptonic decays of B and D mesons into $\pi$ and $\rho$ mesons, respectively, by means of QCD sum rules. We find that for the vector formfactors involved the pole dominance hypothesis is valid to good accuracy with pole masses in the expected range. Pole dominance, however, does not apply to the axial formfactors which results in specific predictions for the predominant polarization of the $\rho$ meson and the shape of the lepton spectrum. For the total decay rates we find $\Gamma (\bar B^0 \to \pi^+ e^- \bar\nu) = (5.1\pm 1.1)\,|V_{ub}|^2\, 10^{12}\,{\rm s^{-1}}$, $\Gamma ( D^0 \to \pi^- e^+ \nu) = (8.0\pm 1.7)\,|V_{cd}|^2\, 10^{10}\,{\rm s^{-1}}$, $\Gamma (\bar B^0 \to \rho^+ e^- \bar\nu) = (1.2\pm 0.4\,)\,|V_{ub}|^2\, 10^{13}\,{\rm s^{-1}}$ and $\Gamma (D^0 \to \rho^- e^+\nu) = (2.4\pm 0.7)\,|V_{cd}|^2\, 10^{9}\,{\rm s^{-1}}$.Comment: 23 pages, 12 figures included as uu-encoded file, needs REVTEX, TUM--T31--39/9

DRASTIC—INSIGHTS:querying information in a plant gene expression database

DRASTIC––Database Resource for the Analysis of Signal Transduction In Cells (http://www.drastic.org.uk/) has been created as a first step towards a data-based approach for constructing signal transduction pathways. DRASTIC is a relational database of plant expressed sequence tags and genes up- or down-regulated in response to various pathogens, chemical exposure or other treatments such as drought, salt and low temperature. More than 17700 records have been obtained from 306 treatments affecting 73 plant species from 512 peer-reviewed publications with most emphasis being placed on data from Arabidopsis thaliana. DRASTIC has been developed by the Scottish Crop Research Institute and the Abertay University and allows rapid identification of plant genes that are up- or down-regulated by multiple treatments and those that are regulated by a very limited (or perhaps a single) treatment. The INSIGHTS (INference of cell SIGnaling HypoTheseS) suite of web-based tools allows intelligent data mining and extraction of information from the DRASTIC database. Potential response pathways can be visualized and comparisons made between gene expression patterns in response to various treatments. The knowledge gained informs plant signalling pathways and systems biology investigations