1,228 research outputs found
Cost of health care utilization among homeless frequent emergency department users
Research demonstrates that homelessness is associated with frequent use of emergency department (ED) services, yet prior studies have not adequately examined the relationship between frequent ED use and utilization of non-ED health care services among those experiencing homelessness. There has also been little effort to assess heterogeneity among homeless individuals who make frequent use of ED services. To address these gaps, the present study used Medicaid claims data from 2010 to estimate the association between the number of ED visits and non-ED health care costs for a cohort of 6,338 Boston Health Care for the Homeless Program patients, and to identify distinct subgroups of persons in this cohort who made frequent use of ED services based on their clinical and demographic characteristics. A series of gamma regression models found more frequent ED use to be associated with higher non-ED costs, even after adjusting for demographic and clinical characteristics. Latent class analysis was used to examine heterogeneity among frequent ED users, and the results identified 6 characteristically distinct subgroups among these persons. The subgroup of persons with trimorbid illness had non-ED costs that far exceeded members of all 5 other subgroups. Study findings reinforce the connection between frequent ED use and high health care costs among homeless individuals and suggest that different groups of homeless frequent ED users may benefit from interventions that vary in terms of their composition and intensity
Quantum metastability in a class of moving potentials
In this paper we consider quantum metastability in a class of moving
potentials introduced by Berry and Klein. Potential in this class has its
height and width scaled in a specific way so that it can be transformed into a
stationary one. In deriving the non-decay probability of the system, we argue
that the appropriate technique to use is the less known method of scattering
states. This method is illustrated through two examples, namely, a moving
delta-potential and a moving barrier potential. For expanding potentials, one
finds that a small but finite non-decay probability persists at large times.
Generalization to scaling potentials of arbitrary shape is briefly indicated.Comment: 10 pages, 1 figure
Relating parton model and color dipole formulation of heavy quark hadroproduction
At high center of mass energies, hadroproduction of heavy quarks can be
expressed in terms of the same color dipole cross section as low Bjorken-x deep
inelastic scattering. We show analytically that at leading order, the dipole
formulation is equivalent to the gluon-gluon fusion mechanism of the
conventional parton model. In phenomenological application, we employ a
parameterization of the dipole cross section which also includes higher order
and saturation effects, thereby going beyond the parton model. Numerical
calculations in the dipole approach agree well with experimental data on open
charm production over a wide range of energy. Dipole approach and next to
leading order parton model yield similar values for open charm production, but
for open bottom production, the dipole approach tends to predict somewhat
higher cross sections than the parton model.Comment: 16 pages, 4 figure
Electronic Structure and Dynamics of Higher-Lying Excited States in Light Harvesting Complex 1 from Rhodobacter sphaeroides
Light harvesting in photosynthetic organisms involves efficient transfer of energy from peripheral antenna complexes to core antenna complexes, and ultimately to the reaction center where charge separation drives downstream photosynthetic processes. Antenna complexes contain many strongly coupled chromophores, which complicates analysis of their electronic structure. Two-dimensional electronic spectroscopy (2DES) provides information on energetic coupling and ultrafast energy transfer dynamics, making the technique well suited for the study of photosynthetic antennae. Here, we present 2DES results on excited state properties and dynamics of a core antenna complex, light harvesting complex 1 (LH1), embedded in the photosynthetic membrane of Rhodobacter sphaeroides. The experiment reveals weakly allowed higher-lying excited states in LH1 at 770 nm, which transfer energy to the strongly allowed states at 875 nm with a lifetime of 40 fs. The presence of higher-lying excited states is in agreement with effective Hamiltonians constructed using parameters from crystal structures and atomic force microscopy (AFM) studies. The energy transfer dynamics between the higher- and lower-lying excited states agree with Redfield theory calculations
Geometric measure of entanglement and applications to bipartite and multipartite quantum states
The degree to which a pure quantum state is entangled can be characterized by
the distance or angle to the nearest unentangled state. This geometric measure
of entanglement, already present in a number of settings (see Shimony 1995 and
Barnum and Linden 2001), is explored for bipartite and multipartite pure and
mixed states. The measure is determined analytically for arbitrary two-qubit
mixed states and for generalized Werner and isotropic states, and is also
applied to certain multipartite mixed states. In particular, a detailed
analysis is given for arbitrary mixtures of three-qubit GHZ, W and inverted-W
states. Along the way, we point out connections of the geometric measure of
entanglement with entanglement witnesses and with the Hartree approximation
method.Comment: 13 pages, 11 figures, this is a combination of three previous
manuscripts (quant-ph/0212030, quant-ph/0303079, and quant-ph/0303158) made
more extensive and coherent. To appear in PR
Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method
<p>Abstract</p> <p>Background</p> <p>Recent experiments have explored effects of activities of kinases other than the well-studied GSK3β, in wnt pathway signaling, particularly at the level of β-catenin. It has also been found that the kinase PKA attenuates β-catenin degradation. However, the effects of these kinases on the level and degradation of β-catenin and the resulting downstream transcription activity remain to be clarified. Furthermore, the effect of GSK3β phosphorylation on the β-catenin level has not been examined computationally. In the present study, the effects of phosphorylation of GSK3β and of phosphorylations and degradation of β-catenin on the kinetics of the wnt signaling pathway were examined computationally.</p> <p>Methods</p> <p>The well-known computational Lee-Heinrich kinetic model of the wnt pathway was modified to include these effects. The rate laws of reactions in the modified model were solved numerically to examine these effects on β-catenin level.</p> <p>Results</p> <p>The computations showed that the β-catenin level is almost linearly proportional to the phosphorylation activity of GSK3β. The dependence of β-catenin level on the phosphorylation and degradation of free β-catenin and downstream TCF activity can be analyzed with an approximate, simple function of kinetic parameters for added reaction steps associated with effects examined, rationalizing the experimental results.</p> <p>Conclusion</p> <p>The phosphorylations of β-catenin by kinases other than GSK3β involve free unphorphorylated β-catenin rather than GSK3β-phosphorylated β-catenin*. In order to account for the observed enhancement of TCF activity, the β-catenin dephosphorylation step is essential, and the kinetic parameters of β-catenin phosphorylation and degradation need to meet a condition described in the main text. These findings should be useful for future experiments.</p
Do mutual funds have consistency in their performance?
Using a comprehensive data set of 714 Chinese mutual funds from 2004 to 2015, the study investigates these funds’ performance persistence by using the Capital Asset Pricing model, the Fama-French three-factor model and the Carhart Four-factor model. For persistence analysis, we categorize mutual funds into eight octiles based on their one year lagged performance and then observe their performance for the subsequent
12 months. We also apply Cross-Product Ratio technique to assess the performance
persistence in these Chinese funds. The study finds no significant evidence of persis- tence in the performance of the mutual funds. Winner (loser) funds do not continue to be winner (loser) funds in the subsequent time period. These findings suggest that future performance of funds cannot be predicted based on their past performance.info:eu-repo/semantics/publishedVersio
Abelian Gauge Fluxes and Local Models in F-Theory
We analyze the Abelian gauge fluxes in local F-theory models with G_S=SU(6)
and SO(10). For the case of G_S=SO(10), there is a no-go theorem which states
that for an exotic-free spectrum, there are no solutions for U(1)^2 gauge
fluxes. We explicitly construct the U(1)^2 gauge fluxes with an exotic-free
bulk spectrum for the case of G_S=SU(6). We also analyze the conditions for the
curves supporting the given field content and discuss non-minimal spectra of
the MSSM with doublet-triplet splitting.Comment: 43 pages, 15 tables; typos corrected, reference adde
Flipped SU(5) GUTs from E_8 Singularities in F-theory
In this paper we construct supersymmetric flipped SU(5) GUTs from E_8
singularities in F-theory. We start from an SO(10) singularity unfolded from an
E_8 singularity by using an SU(4) spectral cover. To obtain realistic models,
we consider (3,1) and (2,2) factorizations of the SU(4) cover. After turning on
the massless U(1)_X gauge flux, we obtain the SU(5) X U(1)_X gauge group. Based
on the well-studied geometric backgrounds in the literature, we demonstrate
several models and discuss their phenomenology.Comment: 46 pages, 23 tables, 1 figure, typos corrected, references added, and
new examples presente
On Global Flipped SU(5) GUTs in F-theory
We construct an SU(4) spectral divisor and its factorization of types (3,1)
and (2,2) based on the construction proposed in [1]. We calculate the chiral
spectra of flipped SU(5) GUTs by using the spectral divisor construction. The
results agree with those from the analysis of semi-local spectral covers. Our
computations provide an example for the validity of the spectral divisor
construction and suggest that the standard heterotic formulae are applicable to
the case of F-theory on an elliptically fibered Calabi-Yau fourfold with no
heterotic dual.Comment: 45 pages, 12 tables, 1 figure; typos corrected, footnotes added, and
a reference adde
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