Bubble shock wave interaction near biomaterials

The interaction of bubbles, both oscillating and stationary near biomaterials is of interest for the development of various medical treatment involving ultrasound and shock waves. This is because cavitation bubbles often nucleate in the bodily fluid under pressure waves, and their dynamics directly influence the success of the treatment and the collateral damages sustained. For example, in the treatment of Extracorporeal Shock Wave Lithotripsy (ESWL), cavitation bubbles are created when the shock wave is administered. These bubbles oscillate and collapse near the kidney stones and the body tissues. They are responsible both for the breaking up of the stones as well as the collateral damages to the nearby tissues. We study the interaction of an oscillating bubble near various biomaterials. The bio-materials are modeled as elastic fluids with similar physical properties such as elastic modulus, Poisson ratio, and density. The bubble dynamics are summarized based on biomaterial physical properties. We also study the interaction of a stationary bubble with the nearby bio-materials when hit by a lithotripter shock wave. High speed jets and splitting of bubbles are observed due to the influence of the nearby biomaterials.http://deepblue.lib.umich.edu/bitstream/2027.42/84287/1/CAV2009-final104.pd

Removal of an obstruction from a tube by a collapsing bubble

The use of a collapsing bubble to clear an obstruction (in the form of a steel ball) near a tube, submerged in water, is studied with high speed photography. Tubes in horizontal and vertical configurations are studied. The bubble is generated via an electric spark discharge. The flow in the tubes resulting from the expansion of the bubble, or the high speed jet from the collapsing bubble pushes the ball away from the tubes and therefore clears the obstructions. In a case where airbacked tube is used, the bubble jets away from the tube. The resulting water plum at the hole (water-air interface) removes the blockage. The speed of the ball can be as high as 1 m/s shortly after the collapse of the bubble. Further studies are required to translate the phenomena observed to clinical applications such as the removal of blood clots in vessels or the clearing of blocked transplanted tubes..http://deepblue.lib.umich.edu/bitstream/2027.42/84282/1/CAV2009-final98.pd

Optical supercavitation in soft-matter

We investigate theoretically, numerically and experimentally nonlinear optical waves in an absorbing out-of-equilibrium colloidal material at the gelification transition. At sufficiently high optical intensity, absorption is frustrated and light propagates into the medium. The process is mediated by the formation of a matter-shock wave due to optically induced thermodiffusion, and largely resembles the mechanism of hydrodynamical supercavitation, as it is accompanied by a dynamic phase-transition region between the beam and the absorbing material.Comment: 4 pages, 5 figures, revised version: corrected typos and reference

Seasonal variation in breast cancer diagnosis in Singapore

This study investigates seasonality in the diagnosis of 3219 female breast carcinoma cases reported between 1995–8 in Singapore. There is little evidence of marked seasonal variation. Angular regression suggested that observed differences in peak diagnosis with respect to menopausal status, tumour size, ER and PR status may be chance. © 2001 Cancer Research Campaign http://www.bjcancer.co

Prevalence and determinants of anxiety and depression in end stage renal disease (ESRD). A comparison between ESRD patients with and without coexisting diabetes mellitus

Objective: To compare anxiety and/or depressive symptoms between patients with end-stage renal disease with and without comorbid diabetes and identify factors associated with symptoms of distress in this population. Methods: Data from two studies (conducted between 2010 and 2014) were pooled. A total of 526 patients on hemodialysis (68.8% with diabetes) completed the Hospital Anxiety and Depression Scale (HADS). Elevated symptoms were defined as HADS-Anxiety or HADS-Depression ≥ 8. Univariate and multivariate logistic regressions were used to estimate associations between diabetic status, and other socio-demographic and clinical factors with baseline clinical anxiety and depression. Results: A total of 233 (45.4%) reported elevated anxiety symptoms and 256 (49.9%) reported elevated depressive symptoms sufficient for caseness. Rates were not different between patients with and without diabetes. Risk for clinical depression was higher in patients who were single/unpartnered (OR = 1.828), Chinese vs. Malay (OR = 2.05), or had lower albumin levels (OR = 0.932). None of the parameters were associated with anxiety caseness. Conclusion: Sociocultural factors rather than comorbid burden may help identify patients at risk for depression. The high rates of anxiety and depression underlie the importance for monitoring and intervention in dialysis care

Assessment of the variability of airborne contamination levels in an intensive care unit over a 24 hour period

Introduction: The objective of this study was to evaluate the variability in the dynamics and levels of airborne contamination within a hospital ICU in order to establish an improved understanding of the extent to which airborne bioburden contributes to cross-infection of patients. Microorganisms from the respiratory tract or skin can become airborne by coughing, sneezing and periods of increased activity such as bed changes and staff rounds. Current knowledge of the clinical microflora is limited however it is estimated that 10-33% of nosocomial infections are transmitted via air. Methods: Environmental air monitoring was conducted in Glasgow Royal Infirmary ICU, in the open ward and in patient isolation rooms. A sieve impactor air sampler was used to collect 500 L air samples every 15 minutes over 10 hour (08:00-18:00 h) and 24 hour (08:00-08:00 h) periods. Samples were collected, room activity logged and the bacterial contamination levels were recorded as CFU/m3 of air. Results: A high degree of variability in levels of airborne contamination was observed over the course of a 10 hour day and a 24 period in a hospital ICU. Counts ranged from 12-510 CFU/m3 over 24 hours in an isolation room occupied for 10 days by a patient with C. difficile infection. Contamination levels were found to be lowest during the night and in unoccupied rooms, with an average value of 20 CFU/m3. Peaks in airborne contamination showed a direct relation to an increase in room activity. Conclusions: This study demonstrates the degree of airborne contamination that can occur in an ICU over a 24 hour period. Numerous factors were found to contribute to microbial air contamination and consideration should be given to potential improved infection control strategies and decontamination technologies which could be deployed within the clinical environment to reduce the airborne contamination levels, with the ultimate aim of reducing healthcare-associated infections from environmental sources

Simple model for decay of superdeformed nuclei

Recent theoretical investigations of the decay mechanism out of a superdeformed nuclear band have yielded qualitatively different results, depending on the relative values of the relevant decay widths. We present a simple two-level model for the dynamics of the tunneling between the superdeformed and normal-deformed bands, which treats decay and tunneling processes on an equal footing. The previous theoretical results are shown to correspond to coherent and incoherent limits of the full tunneling dynamics. Our model accounts for experimental data in both the A~150 mass region, where the tunneling dynamics is coherent, and in the A~190 mass region, where the tunneling dynamics is incoherent.Comment: 4 page