Clinical staging and prognostic factors in folliculotropic mycosis fungoides

Folliculotropic mycosis fungoides (FMF) is a distinct variant of mycosis fungoides (MF), the most prevalent type of cutaneous T cell lymphoma. FMF accounts for approximately 10% of all MF cases and is generally characterized by distinct clinical , histopathologic and prognostic features. The studies in this thesis were aimed to address questions regarding clinical staging, disease course, suitable treatment and prognosis of subgroups of patients with FMF. Alleen voor drukkosten van het proefschrift werd sponsoring ontvangen van: BAP Medical B.V., Eucerin, Galderma Benelux B.V., La Roche-Posay, Kyowa Kirin Pharma B.V., LEO Pharma B.V. en Olmed.LUMC / Geneeskund

Method for producing a supported catalyst

Abstract of WO9903581 The invention relates to a method for producing supported catalysts by impregnating or imbibing SiO2-based crystalline or amorphous support material with a pore diameter of 20 to 250 ANGSTROM with silasesquioxane metal complexes. Said supported catalysts are suitable for oxidising or epoxidising unsaturated hydrocarbons or alcohols

Growth and physiological responses of lettuce grown under pre-dawn or end-of-day sole-source light-quality treatments

The objective of this study was to evaluate growth and physiological responses of ‘Cherokee’ and ‘Waldmann’s Green’ lettuce (Lactuca sativa) exposed to small changes in light quality and intensity within a 24-h period. Three pre-dawn (PD; 0600 to 0700) and three end-of-day (EOD; 2100 to 2200) treatments were evaluated in the study, each providing 50 ± 2 μmol·m−2·s−1 of either blue, red, or broadband white light from light-emitting diodes (LEDs). To account for the main daily light integral (DLI), broadband white LEDs provided 210 ± 2 μmol·m−2·s−1 from 0700 to 2200 or from 0600 to 2100 for the PD or EOD treatments, respectively. A control treatment was included which provided 200 ± 2 μmol·m−2·s−1 of white light from 0600 to 2200. All treatments provided a DLI of 11.5 mol·m−2·day−1 over a 16-h photoperiod. Regardless of cultivar, no treatment difference was measured for hypocotyl length or leaf number. However, plants grown under EOD-blue or PD-white had up to 26% larger leaves than those grown under PD-red and 20% larger leaves than control. In addition, plants grown under EOD-blue produced up to 18% more shoot fresh mass compared to those grown under control, EOD-red, or PD-red. Contrasts for gas-exchange data collected during the main photoperiod showed that light quality was not significant within PD or EOD for any of the parameters evaluated. However, regardless of light quality, stomatal conductance (gs) and transpiration (E) were up to 34% and 42% higher, respectively, for EOD-grown plants compared to control. Our results suggest that 1 h of low intensity EOD-blue light has the potential to promote lettuce growth by increasing leaf area and shoot fresh mass when the main DLI from sole-source lighting is provided by broadband white LEDs

Fluorite transition metal hydride induced destabilization of the MgH2 system in MgH2/TMH2 multilayers (TM=Sc, Ti, V, Cr, Y, Zr, Nb, La, Hf)

The structural changes in MgH2 induced by contact with fluorite transition metal hydrides (TMH2, TM=Sc, Ti, V, Cr, Y, Zr, Nb, La, Hf) have been studied using density-functional theory calculations. Models of MgH2(rutile)/TiH2(fluorite) and MgH2(fluorite)/TiH2(fluorite) multilayers with different Mg:TM ratios have been designed. With a fixed thickness of the TMH2 layer, structure transformation of MgH2 from rutile to fluorite occurs with a decrease in thickness of the MgH2 layer. The hydrogen desorption energy from the fluorite MgH2 layer in the multilayers is significantly lower than that of the bulk rutile MgH2. The structural deformation of the MgH2 layer due to the strain induced by TMH2 is found to be responsible for the destabilization of the Mg-H bond: the more structural deformation, the more destabilization of the Mg-H. Our results provide an important insight for the development of new hydrogen-storage materials with desirable thermodynamic properties

Modeling the Interdependences between Voltage Fluctuation and BTI Aging

With technology scaling, the susceptibility of circuits to different reliability degradations is steadily increasing. Aging in transistors due to bias temperature instability (BTI) and voltage fluctuation in the power delivery network of circuits due to IR-drops are the most prominent. In this paper, we are reporting for the first time that there are interdependences between voltage fluctuation and BTI aging that are nonnegligible. Modeling and investigating the joint impact of voltage fluctuation and BTI aging on the delay of circuits, while remaining compatible with the existing standard design flow, is indispensable in order to answer the vital question, “what is an efficient (i.e., small, yet sufficient) timing guardband to sustain the reliability of circuit for the projected lifetime?” This is, concisely, the key goal of this paper. Achieving that would not be possible without employing a physics-based BTI model that precisely describes the underlying generation and recovery mechanisms of defects under arbitrary stress waveforms. For this purpose, our model is validated against varied semiconductor measurements covering a wide range of voltage, temperature, frequency, and duty cycle conditions. To bring reliability awareness to existing EDA tool flows, we create standard cell libraries that contain the delay information of cells under the joint impact of aging and IR-drop. Our libraries can be directly deployed within the standard design flow because they are compatible with existing commercial tools (e.g., Synopsys and Cadence). Hence, designers can leverage the mature algorithms of these tools to accurately estimate the required timing guardbands for any circuit despite its complexity. Our investigation demonstrates that considering aging and IR-drop effects independently, as done in the state of the art, leads to employing insufficient and thus unreliable guardbands because of the nonnegligible (on average 15% and up to 25%) underestimations. Importantly, considering interdependences between aging and IR-drop does not only allow correct guardband estimations, but it also results in employing more efficient guardbands

Аналіз ефективності використання потенціалу матеріальних ресурсів підприємства

Метою даного дослідження виступає пошук аналітичних можливостей комплексної оцінки та аналізу використання потенціалу матеріальних ресурсів та визначення шляхів підвищення ефективності використання матеріальних ресурсів підприємства

The partially asymmetric zero range process with quenched disorder

We consider the one-dimensional partially asymmetric zero range process where the hopping rates as well as the easy direction of hopping are random variables. For this type of disorder there is a condensation phenomena in the thermodynamic limit: the particles typically occupy one single site and the fraction of particles outside the condensate is vanishing. We use extreme value statistics and an asymptotically exact strong disorder renormalization group method to explore the properties of the steady state. In a finite system of $L$ sites the current vanishes as $J \sim L^{-z}$, where the dynamical exponent, $z$, is exactly calculated. For $0<z<1$ the transport is realized by $N_a \sim L^{1-z}$ active particles, which move with a constant velocity, whereas for $z>1$ the transport is due to the anomalous diffusion of a single Brownian particle. Inactive particles are localized at a second special site and their number in rare realizations is macroscopic. The average density profile of inactive particles has a width of, $\xi \sim \delta^{-2}$, in terms of the asymmetry parameter, $\delta$. In addition to this, we have investigated the approach to the steady state of the system through a coarsening process and found that the size of the condensate grows as $n_L \sim t^{1/(1+z)}$ for large times. For the unbiased model $z$ is formally infinite and the coarsening is logarithmically slow.Comment: 12 pages, 9 figure