A two-rigid block model for sliding gravity retaining walls

This paper presents a new two rigid block model for sliding gravity retaining walls. Some conceptual limitations of a direct application of Newmark's sliding block method to the case of retaining walls are discussed with reference to a simple scheme of two interacting rigid blocks on an inclined plane. In particular, it is shown that both the internal force between the blocks and their absolute acceleration are not constant during sliding, and must be computed by direct consideration of the dynamic equilibrium and kinematic constraints for the whole system. The same concepts are extended to the analysis of the active soil wedge-wall system, leading to an extremely simple procedure to compute the relative displacements of the wall when subjected to base accelerations exceeding the critical value. A comparison with the results of numerical analyses demonstrates that the proposed method is capable of describing fully the kinematics of the soil wedge-wall system under dynamic loading. On the contrary, direct application of Newmark's method may lead to inaccurate predictions of the final displacements, in excess or in defect depending on a coefficient, which emerges from direct consideration of the dynamic equilibrium of the whole system. This coefficient can be viewed as a corrective factor for the horizontal relative acceleration of the wall, related to the mechanical and geometrical properties of the soil-wall system

Soil-structure interaction for the seismic design of the Messina Strait Bridge

This paper illustrates an approach to the study of the seismic soil–structure interaction that was developed at the verification stage of the design of the Messina Strait Bridge in order to validate its seismic behaviour. It consisted of a series of two-dimensional, plane strain numerical analyses on models that included, in addition to the embedded foundation elements, a simplified structural description of the bridge towers: simplified structural models were specifically designed to reproduce the first vibrations modes of the towers, that were deemed to have the most significant influence on the system's dynamic response. Non-linear dynamic analyses were carried out in the time domain, studying the effects of two different natural records, each characterised by three orthogonal components of the soil motion. In the first part of the paper, essential information is provided about the foundations layout, the main properties of the foundation soil resulting from the in situ and laboratory investigation, and the assessment of the liquefaction potential. Then, the numerical models are discussed in some detail, with an emphasis on the modelling of the soil and of the structural elements. For sake of conciseness, details are provided only for one of the two shores. The results obtained with the present approach shed some light on the complex coupling between the soil's and the structure's behaviour, evidencing the significant role that the embedded, massive foundations of the bridge play in the dynamic response of the system. The computed time-histories of the displacements of the foundation elements are used to assess the seismic performance of the bridge

Predicting the seismic behaviour of the foundations of the Messina Strait Bridge

This paper presents some of the geotechnical studies carried out for the seismic design of the one-span suspension bridge across the Messina Strait, that is to connect Sicily with mainland Italy. These studies included advanced geotechnical characterisation, through in situ and laboratory tests, estimate of site stability involving both liquefaction analysis and submerged slope stability, evaluation of soil-foundation stiffness for spectral analysis of the superstructure, 3D FE static calculations, evaluation of anchor block performance under seismic conditions, and full dynamic analyses of the soil-structure interaction. The paper summarises the main results obtained from the geotechnical characterisation of the foundation soils, reports the approach adopted for evaluating the seismic performance of the anchor blocks through a modified Newmark-type calculation, and presents the study of the soil-structure interaction carried out through a series of two-dimensional, plane strain numerical analyses. In these analyses, in addition to the embedded foundation elements, the models included a simplified structural description of the bridge towers specifically designed to reproduce their first vibrations modes, that were deemed to have the most significant influence on the system's dynamic response. The illustration is limited to the foundation systems of the bridge located on the Sicily shore

Protein induced by vitamin K absence or antagonist-II (PIVKA-II) specifically increased in Italian hepatocellular carcinoma patients

OBJECTIVE: As a marker for Hepatocellular Carcinoma (HCC), Protein Induced by Vitamin K Absence II (PIVKA-II) seems to be superior to alpha fetoprotein (AFP). To better characterize the role of PIVKA-II, both AFP and PIVKA-II have been measured in Italian patients with diagnosis of HCC compared with patients affected by non-oncological liver pathologies. MATERIALS AND METHODS: Sixty serum samples from patients with HCC, 60 samples from patients with benign liver disease and 60 samples obtained from healthy blood donors were included in the study. PIVKA-II and AFP were measured by LUMIPULSE(®) G1200 (Fujirebio-Europe, Belgium). We considered as PIVKA-II cutoff 70 mAU/ml (mean +3SD) of the values observed in healthy subjects. RESULTS: The evaluation of PIVKA-II showed a positivity of 70% in patients with HCC and 5% in patients with benign diseases (p < 0.0001) whereas high levels of AFP were observed in 55% of HCC patients and in 47% of patients with benign diseases. The combined Receiver Operating Characteristic (ROC) analysis of the two analytes revealed a higher sensitivity (75%) compared to those observed for the individual biomarkers. In conclusion, we demonstrate that as a marker for HCC, PIVKA-II is more specific for HCC and less prone to elevation during chronic liver diseases. CONCLUSIONS: The combination of the two biomarkers, evaluated by the ROC analysis, improved the specificity compared to a single marker. These data suggest that the combined analysis of the two markers could be a useful tool in clinical practice

Triaxial tests on frozen ground: formulation and modelling

Artificial Ground Freezing (AGF) is a controllable process that can be used by engineers to stabilise temporarily the ground, provide structural support and/or exclude groundwater from an excavation until construction of the final lining provides permanent stability and water tightness. In this work, the process of ground freezing is studied using a constitutive model that encompasses frozen and unfrozen behaviour within a unified effective-stress- based framework and employs a combination of ice pressure, liquid water pressure and total stress as state variables. The parameters of the constitutive model are calibrated against experimental data obtained from samples retrieved during construction of Napoli underground, in which AGF was extensively used to excavate in granular soils and weak fractured rock below the ground water table.Postprint (published version

First report on egg-parasitoids of the Asian planthopper Ricania speculum

The first findings of egg-parasitoids of the invasive planthopper Ricania speculum (Walker) (Hemiptera Ricaniidae) are presented. Aprostocetus (Ootetrastichus) crino (Walker) (Hymenoptera Eulophidae), a native species until now only associated with Oecanthus spp. (Orthoptera Oecanthidae) eggs, was the most common. Chaetostricha similis (Silvestri) (Hymenoptera Trichogrammatidae) and Polynema sp. (Hymenoptera Mymaridae), which also emerged from R. speculum egg clusters, should be confirmed as parasitoids of this planthopper

A micro finite element model for soil behaviour: experimental evaluation for sand under triaxial compression

This paper evaluates the ability of a combined discrete-finite element approach to replicate the experimental response of a dry sand under triaxial compression. The numerical sample was created by virtualising the fabric of a Martian regolith-like sand sample obtained from an in-situ test using X-ray micro Computed Tomography and physical properties of the grains obtained from laboratory data were used as input. The boundary and contact conditions were defined according to the experimental test. A key feature of the model is the use of deformable thin-shell elements to represent the numerical membrane, which allows for a realistic failure mode and volumetric deformation. The macroscopic response of the numerical simulation is shown to compare well with the experiment. The contact regions are identified based on their ability to transmit stress and the evolution of the contact normals is shown to correlate well with the macro stress evolution. The computed stress fields within each grain are used to identify the load bearing grains in the assembly, contributing new insights beyond the commonly reported force chains

Artificial ground freezing of a volcanic ash: Laboratory tests and modelling

The use of artificial ground freezing (AGF) to form earth support systems has had applications worldwide. These cover a variety of construction problems, including the formation of frozen earth walls to support deep excavations, structural underpinning for foundation improvement and temporary control of ground water in construction processes. On one hand, the main advantage of AGF as a temporary support system in comparison to other support methods, such as those based on injections of chemical or cement grout into the soil, is the low impact on the surrounding environment as the refrigerating medium required to obtain AGF is circulated in pipes and exhausted in the atmosphere or re-circulated without contamination of the ground water. On the other hand, the available methods may vary significantly in their sustainability and complexity in terms of times and costs required for their installation and maintenance. The ability to predict the effects induced by AGF on granular materials is therefore crucial to assessing construction time and cost and to optimising the method. In this work, the thermo-hydro-mechanical processes induced by artificial freezing of a soil body are studied using a constitutive model that encompasses frozen and unfrozen behaviour within a unified effective-stress-based framework. It makes use of a combination of ice pressure, liquid water pressure and total stress as state variables. The model is validated and calibrated using the results of a series of laboratory tests on natural samples of a volcanic ash (Pozzolana) retrieved during construction of Napoli underground, where the technique of AGF was used extensively to stabilise temporarily the ground and control the ground water

Strategies for analyzing highly enriched IP-chip datasets

BACKGROUND: Chromatin immunoprecipitation on tiling arrays (ChIP-chip) has been employed to examine features such as protein binding and histone modifications on a genome-wide scale in a variety of cell types. Array data from the latter studies typically have a high proportion of enriched probes whose signals vary considerably (due to heterogeneity in the cell population), and this makes their normalization and downstream analysis difficult. RESULTS: Here we present strategies for analyzing such experiments, focusing our discussion on the analysis of Bromodeoxyruridine (BrdU) immunoprecipitation on tiling array (BrdU-IP-chip) datasets. BrdU-IP-chip experiments map large, recently replicated genomic regions and have similar characteristics to histone modification/location data. To prepare such data for downstream analysis we employ a dynamic programming algorithm that identifies a set of putative unenriched probes, which we use for both within-array and between-array normalization. We also introduce a second dynamic programming algorithm that incorporates a priori knowledge to identify and quantify positive signals in these datasets. CONCLUSION: Highly enriched IP-chip datasets are often difficult to analyze with traditional array normalization and analysis strategies. Here we present and test a set of analytical tools for their normalization and quantification that allows for accurate identification and analysis of enriched regions

A microstructural finite element analysis of cement damage on Fontainebleau Sandstone

This paper presents a numerical simulation that uses tomographic data to reproduce the grain-scale mechanisms taking place during deformation of Fontainebleau sandstone. Previous investigation using x-ray tomographic images acquired during triaxial compression has highlighted the role of bonding rupture mechanisms in the failure mode of the material. The model the deformation of the sandstone, images of the internal topology were used to generate an image-based finite element mesh and the grain-scale phenomena such as, the opening and propagation of the cracks associated with the debonding of the cemented grains, were reproduced using a simple constitutive model