Menopause and premature ovarian insufficiency in rheumatic diseases: A review

Premature ovarian insufficiency (POI) is a clinical syndrome defined as loss of ovarian function before the age of 40 years. Among the causes of POI are genetic, metabolic disorders, as well as infectious or iatrogenic factors, but in some cases the exact cause cannot be established. Given the possible association of ovarian failure with autoimmune disorders, as well as the detection of antibodies to normal ovarian tissue in the serum of patients with POI, it is assumed that an autoimmune mechanism is a significant cause of the syndrome. Taking into account the relationship between POI and autoimmune diseases, it seems relevant to address the issues of mutual influence of the ovarian function of women with POI and rheumatic diseases (in particular, systemic lupus erythematosus, rheumatoid arthritis and systemic scleroderma), which is presented in this review. Hormone replacement therapy may be recommended for women with POI to improve their quality of life. Keywords: premature ovarian insufficiency, menopause, anti-ovarian antibodies, systemic lupus erythematosus, rheumatoid arthritis, systemic scleroderma, rheumatic diseases, hormone replacement therapy

Properties of Neutral Charmed Mesons in Proton--Nucleus Interactions at 70 GeV

The results of treatment of data obtained in the SERP-E-184experiment "Investigation of mechanisms of the production of charmed particles in proton-nucleus interactions at 70 GeV and their decays" by irradiating the active target of the SVD-2 facility consisting of carbon, silicon, and lead plates, are presented. After separating a signal from the two-particle decay of neutral charmed mesons and estimating the cross section for charm production at a threshold energy {\sigma}(c\v{c})=7.1 \pm 2.4(stat.) \pm 1.4(syst.) \mub/nucleon, some properties of D mesons are investigated. These include the dependence of the cross section on the target mass number (its A dependence); the behavior of the differential cross sections d{\sigma}/dpt2 and d{\sigma}/dxF; and the dependence of the parameter {\alpha} on the kinematical variables xF, pt2, and plab. The experimental results in question are compared with predictions obtained on the basis of the FRITIOF7.02 code.Comment: 9 pages, 9 figures,3 table

Observation of narrow baryon resonance decaying into pKs0pK^0_s in pA-interactions at 70GeV/c70 GeV/c with SVD-2 setup

SVD-2 experiment data have been analyzed to search for an exotic baryon state, the $\Theta^+$-baryon, in a $pK^0_s$ decay mode at $70 GeV/c$ on IHEP accelerator. The reaction $pA \to pK^0_s+X$ with a limited multiplicity was used in the analysis. The $pK^0_s$ invariant mass spectrum shows a resonant structure with $M=1526\pm3(stat.)\pm 3(syst.) MeV/c^2$ and $\Gamma < 24 MeV/c^2$. The statistical significance of this peak was estimated to be of $5.6 \sigma$. The mass and width of the resonance is compatible with the recently reported $\Theta^+$- baryon with positive strangeness which was predicted as an exotic pentaquark ($uudd\bar{s}$) baryon state. The total cross section for $\Theta^+$ production in pN-interactions for $X_F\ge 0$ was estimated to be $(30\div120) \mu b$ and no essential deviation from A-dependence for inelastic events $(\sim A^{0.7})$ was found.Comment: 8 pages, 7 figures, To be submitted to Yadernaya Fizika. v3-v5 - Some references added, minor typos correcte

Клиническое значение и перспективы применения инъекционных форм биополимерного микрогетерогенного коллагенсодержащего гидрогеля в терапии остеоартрита

The paper gives the current definition of osteoarthritis (OA), which reflects the pathogenetic and clinical characteristics of this disease, as well as general principles for choosing an OA treatment. It describes the effect of glucosamine and chondroitin on the key pathogenetic mechanisms of OA. It is noted that one of the promising areas of therapy for OA is the intra-articular administration of biopolymer-based hydrogels that provide not only an anti-inflammatory, but also regenerative effect that has been experimentally confirmed during their injection into the tendon sheaths. There are data on the efficacy and safety of the Russian drug Sphero®gel, a biopolymer-based microheterogeneous collagen-containing hydrogel that belongs to a class of multicomponent biopolymer-based extracellular matrix mimetics. It consists of the cross-linked farm animal tissue-derived collagen microparticles placed in the gel base. The gel is not only a structural base for collagen microparticles; it also has its own therapeutic potential, since it is structurally similar to the natural extracellular matrix. The drug contains collagen, biologically active components of the extracellular matrix, such as proteoglycans, glycoproteins, uronic acids, growth factors, monosaccharides, and chondroitin sulfate. Extended-release symptomatic agents, Sphero®gel among them, are currently recommended for the treatment of OA. Application of Sphero®gel contributes to increased joint mobility and reduced pain, which allows the limited use of nonsteroidal anti-inflammatory drugs that cause adverse reactions, especially in the presence of comorbid diseases.В статье представлены современная дефиниция остеоартрита (ОА), отражающая его патогенетические и клинические характеристики, и основные принципы выбора лечения при ОА. Описано воздействие глюкозамина и хондроитина на ведущие патогенетические механизмы ОА. Отмечено, что одним из перспективных направлений терапии ОА является внутрисуставное введение гидрогелевых форм биополимерных материалов, обеспечивающих не только противовоспалительный, но и регенеративный эффект, экспериментально подтвержденный при их введении в сухожильные влагалища. Приведены данные об эффективности и безопасности отечественного препарата Сферо®ГЕЛЬ – биополимерного микрогетерогенного коллагенсодержащего гидрогеля, который относится к классу многокомпонентных биополимерных миметиков внеклеточного матрикса. Он состоит из помещенных в гелевую основу микрочастиц «сшитого» коллагена, полученного из тканей сельскохозяйственных животных. Гель – не только структурная база для микрочастиц коллагена, он обладает также собственным терапевтическим потенциалом, поскольку по составу идентичен природному внеклеточному матриксу. Препарат содержит коллаген, биологически активные компоненты внеклеточного матрикса – протеогликаны, гликопротеины, уроновые кислоты, факторы роста, моносахариды, хондроитина сульфат. В настоящее время симптоматические препараты замедленного действия, в число которых входит Сферо®ГЕЛЬ, рекомендуется назначать при лечении ОА. Применение Сферо®геля способствует увеличению подвижности суставов и уменьшению боли, что позволяет ограничить использование нестероидных противовоспалительных препаратов, вызывающих неблагоприятные реакции, особенно при наличии коморбидных заболеваний

EFFECT OF OXYGEN ON THE KINETICS OF METHYLENE BLUE DECOLORIZATION BY ASCORBIC ACID

This paper presents the results of studying the effect of oxygen on the decolorization rate of the redox reaction of the thiazine dye methylene blue with ascorbic acid. The mechanism of the influence of oxygen on the decolorization reaction and intermediate stages and reaction products are described.The reported study was funded by RFBR, project number 20-33-90152.Исследование выполнено при финансовой поддержке РФФИ в рамках научного проекта № 20-33-90152

Charge Fluctuations in \pi^{+}\rp and \rK^{+}\rp Collisions at 250 GeV/cc

We report on measurements of event-by-event charge fluctuations in \pi^{+}\rp and \rK^{+}\rp collisions at 250 GeV/$c$. The dependence of these fluctuations on the size of the rapidity windows are presented for the first time in the full phase space domain. The corrections for the influence of global charge conservation and leading-particle stopping are tested by the data. The discrepancy due to incomplete correction given by STAR and PHENIX are estimated. The dependence of the fluctuations on the position of the rapidity bin and on the multiplicity at different rapidity windows are also presented.Comment: 4pages, 3figure

Measurement of neutral current e+/-p cross sections at high Bjorken x with the ZEUS detector

The neutral current e+/-p cross section has been measured up to values of Bjorken x of approximately 1 with the ZEUS detector at HERA using an integrated luminosity of 187 inv. pb of e-p and 142 inv. pb of e+p collisions at sqrt(s) = 318GeV. Differential cross sections in x and Q2, the exchanged boson virtuality, are presented for Q2 geq 725GeV2. An improved reconstruction method and greatly increased amount of data allows a finer binning in the high-x region of the neutral current cross section and leads to a measurement with much improved precision compared to a similar earlier analysis. The measurements are compared to Standard Model expectations based on a variety of recent parton distribution functions.Comment: 39 pages, 9 figure