(3+1)-Dimensional Hydrodynamic Expansion with a Critical Point from Realistic Initial Conditions

We investigate a (3+1)-dimensional hydrodynamic expansion of the hot and dense system created in head-on collisions of Pb+Pb/Au+Au at beam energies from $5-200A$ GeV. An equation of state that incorporates a critical end point (CEP) in line with the lattice data is used. The necessary initial conditions for the hydrodynamic evolution are taken from a microscopic transport approach (UrQMD). We compare the properties of the initial state and the full hydrodynamical calculation with an isentropic expansion employing an initial state from a simple overlap model. We find that the specific entropy ($S/A$) from both initial conditions is very similar and only depends on the underlying equation of state. Using the chiral (hadronic) equation of state we investigate the expansion paths for both initial conditions. Defining a critical area around the critical point, we show at what beam energies one can expect to have a sizable fraction of the system close to the critical point. Finally, we emphasise the importance of the equation of state of strongly interacting matter, in the (experimental) search for the CEP.Comment: 8 pages, 8 figure

Phase Structure in a Hadronic Chiral Model

We study the phase diagram of a hadronic chiral flavor-SU(3) model. Heavy baryon resonances can induce a phase structure that matches current results from lattice-QCD calculations at finite temperature and baryon density. Furthermore, we determine trajectories of constant entropy per net baryon in the phase diagram.Comment: 4 pages, 5 figure

Surface modification of steel inductor as an approach to enchance its durability in high pulsed magnetic fields

The work concerns both a theoretical analysis of magnetic and thermal effects in conductor with inhomogeneous initial conductivity and realization of this approach on steel, oriented on inductors production, by steel surface modification. Monotonically changing spe-cific resistance of steel was suggested to be realized via steel pack chromizing.This work was performed as part of state task No. 0389-2015-0025 and supported in part by RAS Program Project No.18-2-2-8

Развитие системы государственного финансирования обязательного медицинского страхования

Objective: to study the potential for the development of financing the Compulsory Health Insurance (CHI) system in Russia.Material and methods. Оur research estimates the amount of funds available in the CHI system based on fractal analysis and ARIMA modeling. The proposed approach makes it possible to determine the critical amount of funds in the CHI system. Once the limit is reached, the chance of violating the economic security requirements will increase. Results. Аn increase in the volume of available funds in the CHI sector is expected in the mid-term perspective on the verge of quarter 1, 2023. The amount of funds required to pay for medical care for the respective period of time will increase by 0.77% quarterly.Conclusion. Gaining additional funds might be possible by optimizing the internal networks for generating cash flows in the CHI system, as well as applying additional ways of financing medical care (particularly Voluntary Health Insurance policies). It would be practical to redistribute the functions of financing health care between the Federal Fund for CHI and its territorial branches. It is essential to review the role of health insurance companies in monitoring the health care quality by improving the communication with citizens.Цель: изучение возможностей развития финансирования системы обязательного медицинского страхования (ОМС) в Российской Федерации.Материал и методы. На основе фрактального анализа и методов ARIMA-моделирования выполнены оценки объема средств, доступных в системе ОМС. Предложенный подход позволяет определить критический объем средств в системе ОМС, достижение которого отражает высокую вероятность нарушения требований экономической безопасности.Результаты. Установлено, что в среднесрочной перспективе будет наблюдаться увеличение объемов доступных средств в сфере ОМС на горизонте до I квартала 2023 г. Прирост показателя объема средств, предназначенных для оплаты медицинской помощи, за рассматриваемый период составит 0,77% ежеквартально.Заключение. Высвобождение дополнительных денежных средств возможно за счет оптимизации внутренних механизмов формирования денежных потоков в системе ОМС, а также привлечения дополнительных инструментов финансирования медицинской помощи (в частности, добровольного медицинского страхования). Целесообразно осуществить перераспределение функций финансирования медицинской помощи между федеральным фондом ОМС и его территориальными подразделениями. Необходим пересмотр роли страховых медицинских организаций при мониторинге качества оказываемой медицинской помощи за счет улучшения механизмов взаимодействия с гражданами

The activity of matrix metalloproteinases and the concentration of their tissue inhibitors in the blood serum of patients with type 2 diabetes mellitus, depending on the stage of compensation of the disease

The aim of the study was to test the hypothesis on the possible reason for the decrease in the activity of matrix metalloproteinases (MMPs) as a consequence of the high concentration of their tissue inhibitors (TIMPs) in the blood serum of patients with type 2 diabetes mellitus (T2DM). Material and methods. In the experimental part of the article, we used the blood serum of patients under observation in the clinic of the Federal Research Center of Fundamental and Translational Medicine. According to the content of glycated hemoglobin (HbA1С) in blood serum, the patients were divided into 3 groups: at the stage of compensation (6.0–6.5 % HbA1С), at the stage of subcompensation (6.6–7.0 % HbA 1С) and decompensation (> 7.0 % HbA1С). The activity of MMPs 2 and 7 in blood serum samples was measured by a fluorimetric method using a fluorescent substrate specific for these MMPs. The concentration of TIMP-1 (inhibitor of all non-membrane-bound MMPs) and TIMP-2 (active against MMP-2 and -7) in blood serum were determined by enzyme immunoassay. Results and discussion. In patients with T2DM, the MMP-2 and -7 activities decreased, more pronouncedly at the stage of decompensation. An increase in the concentration of TIMP-1 was observed in the serum of all patients, while no significant changes in the content of TIMP-2 were found. At the stage of decompensation, a decrease in MMP activity was accompanied by a decrease in the content of insulin, C-peptide and a corresponding increase in the level of proinsulin. An inverse correlation was found between the concentrations of TIMP-1 and insulin in patients at the stage of decompensation of T2DM. It is assumed that the activity of MMP-2 and -7, in comparison with their inhibitors, forms stronger correlations with the parameters of carbohydrate metabolism

Hydrodynamics with a chiral hadronic equation of state including quark degrees of freedom

We investigate the influence of a deconfinement phase transition on the dynamics of hot and dense nuclear matter. We apply a hybrid model where an intermediate hydrodynamics stage is employed for the the hot and dense stage of a system created in head-on collisions of Pb+Pb/Au+Au at beam energies from $2-160A$GeV. The initial and final interactions are performed by a microscopic transport approach (UrQMD). An equation of state that incorporates a critical end point (CEP) in line with lattice data is used. It follows from coupling the Polyakov loop (as an order parameter for deconfinement) to a chiral hadronic $SU(3)_f$ model. In this configuration the EoS describes chiral restoration as well as the deconfinemt phase transition. We compare the results obtained in this approach to results from a non interacting hadron resonance gas, focussing on observables deemed to be sensitive to the phase transition to the quark gluon plasma.Comment: Published versio

Apolipoprotein A-I increases the activity of lysosomal glycosidases in the liver of mice with BCG-induced tuberculosis inflammation

This work shows the ability of apolipoprotein A-I to influence the activity of lysosomal glycosidases in the liver of mice in a model of BCG-induced tuberculous inflammation. The aim of the investigation was to study the activity of lysosomal glycosidases in the liver of mice using a model of BCG-induced tuberculous inflammation after intravenous administration of apolipoprotein A-I. Material and methods. The studies were performed on male CBA mice weighing 20-22 g. Disseminated tuberculous inflammation was modeled by a single intraperitoneal injection of 0.5 mg of BCG vaccine. The activity of lysosomal glycosidases was assessed spectrofluorimetrically by the content of hydrolysis products of the corresponding fluorogenic substrates. Results. Tuberculous inflammation led to a pronounced decrease in the activity of lysosomal glycosidases in the liver. Thus, β-galactosidase was decreased 2.3 times, β-glucosidase – 2.8 times, β-glucuronidase – 2.5 times compared with healthy animals. Intravenous injection of apolipoprotein A-I to animals against the background of BCG infection prevented a significant decrease in the enzymatic activity of glycosidases and these values practically did not differ from the control values. Conclusions. Enzymatic activity of lysosomal glycosidases in the group of mice with intravenous administration of apolipoprotein A-I against the background of BCG infection was 1.5–2 times higher than the corresponding indicators in the group of animals with BCG-infection without administration of apolipoprotein A-I, i.e. without treatment

Catalytic Reactions in Heavy-ion Collisions

We discuss a new type of reactions of a phi meson production on hyperons, pi Y--> phi Y and anti-kaons bar-K N --> phi Y. These reactions are not suppressed according to Okubo-Zweig-Iizuka rule and can be a new efficient source of phi mesons in a nucleus-nucleus collision. We discuss how these reactions can affect the centrality dependence and the rapidity distributions of the phi yield.Comment: talk at 6th International Workshop on Critical Point and Onset of Deconfinment (CPOD2010), Dubna, August 22-28, 201

Evolution of Baryon-Free Matter Produced in Relativistic Heavy-Ion Collisions

A 3-fluid hydrodynamic model is introduced for simulating heavy-ion collisions at incident energies between few and about 200 AGeV. In addition to the two baryon-rich fluids of 2-fluid models, the new model incorporates a third, baryon-free (i.e. with zero net baryonic charge) fluid which is created in the mid-rapidity region. Its evolution is delayed due to a formation time $\tau$, during which the baryon-free fluid neither thermalizes nor interacts with the baryon-rich fluids. After formation it thermalizes and starts to interact with the baryon-rich fluids. It is found that for $\tau$=0 the interaction strongly affects the baryon-free fluid. However, at reasonable finite formation time, $\tau$=1 fm/c, the effect of this interaction turns out to be substantially reduced although still noticeable. Baryonic observables are only slightly affected by the interaction with the baryon-free fluid.Comment: 17 pages, 3 figures, submitted to the issue of Phys. of Atomic Nuclei dedicated to S.T. Belyaev on the occasion of his 80th birthday, typos correcte