Evaluation of pharmacological correction of L-NAME-induced endothelial dysfunction, platelet aggregation and venous tone with diosmin detralex 1000 mg

Chronic venous diseases are one of the urgent problems of modern medicine. Recent studies have shown high significance of endothelial dysfunction (ED) and oxidative stress in their pathogenesis. For the correction of the occurring changes, drugs of the flavonoid group, particularly diosmin and hesperidin, are currently use

Simulation of total brain ischemia in rats

This paper deals with the study of the dependence of psycho neurological deficit in rats on the severity of brain damage, conducted on the four-vascular models of total cerebral ischemia. The obtained results demonstrate a tendency to deterioration of neuropsychiatric status of the animals with increasing severity of ischemic brain damage that allows suggesting the severity of ischemic brain damage and its correction by the degree of behavioral disorder

Influence of silver-ion-containing pharmacotherapeutic system for repair of anterior abdominal wall on connective tissue formation in experiment

In modern medicine new pharmacotherapeutic systems significantly reducing the risk of complications are being actively searched for. The study undertaken was aimed at studying one of such systems consisting of a prosthesis coated with silver ions. The article notes that use of FCS contributes to the acceleration of reparative processes, earlier resolution of inflammation and stimulation of collagenesis both under sterile conditions and under microbial condition

Study of analgesic activity and effects of new dipharmacophores - nebracetam and cyclooxygenase-2 inhibitors derivatives on the cognitive abilities of rats

The aim of the present study was to research the analgesic activity and effect of new dipharmacophore compounds consisting of substances with proven therapeutic activity, namely nebracetam-ibuprofen (NRIP), nebracetam-dexibuprofen (NRDIP), nebracetam-niflumic acid (NRNFA), and nebracetam-mefenamic acid (NRMFA), on the cognitive abilities of rat

Integrated evaluation of the endothelioprotective activity of an innovative peptide simulating the alpha-helix of B-erythropoethin in L-name-induced nitrogen oxide deficiency at the late gestation period

To study the efficiency of using carbamylated darbepoetin, asialized erythropoietin and an 11-amino acid peptide that simulating the spatial structure of the B-erythropoietin alpha-helix in the correction of L-NAME-induced nitric oxide deficiency in the late gestation perio

Retinoprotective effects of non-selective imidazoline receptor agonists

Current drug therapy of ophtalmic diseases associated with retinal ischemia is not always successful enough that ensures the relevance of the search of new effective drug

PRECLINICAL INVESTIGATION OF THE ALLERGENIC EFFECT OF THE DRUG BASED ON THE PHENOLIC COMPOUND KUD975

Introduction: Vascular endothelium is a cellular monolayer that covers the internal lumen of all blood vessels, thus separating blood from the vessel wall and tissues. The study of the role of endothelium in the pathogenesis of cardiovascular diseases led to an understanding of the concept of it as a target for the prevention and treatment of these pathologies. Research tasks: The purpose of this study was preclinical study of the allergic effect of the drug KUD975, based on a phenolic compound, which is a selective inhibitor of arginase 2. Methods: Experiments on the allergic properties of the phenolic compound KUD975, which is a selective inhibitor of arginase II, were carried out on albino sexually mature guinea pigs weighing 300 ± 20 g. The preparation was administered intragastrically as a suspension in a 1% starch paste using a specially prepared atraumatic probe at 0, 1 ml of suspension per 10 g of body weight of animals. As a control, we used data obtained in animals with intragastric administration of the corresponding volume of placebo-1% starch paste. Results: In the course of the study of the allergic properties of KUD975, when the reaction of active cutaneous anaphylaxis was formulated, it was found that the studied preparation in two and eight times daily therapeutic dosages did not possess allergic properties In the course of the study of the allergic properties of KUD975 in the formulation of a delayed-type hypersensitivity reaction, it was found that the study drug in two and eight times daily therapeutic dosages had no allergenic properties. Erythema, or, especially, infiltration and the appearance of ulcers at the site of administration as a resolving dose of the drug, as well as in the control of reactivity, were not observed in any animal participating in the experiment. Conclusion: When investigating the allergenic properties of the phenolic compound KUD975, which is a selective inhibitor of arginase II in the reaction of active cutaneous anaphylaxis, it was found that the study preparation in two and eight times daily therapeutic dosages does not have allergic properties. In the reaction of active cutaneous anaphylaxis in guinea pigs, the allergic properties of KUD975 in two and eight times daily therapeutic dosages were not detected Key words: compounds of phenolic nature, allergic action, endothelium, inhibitors of arginase I

Assessment of the nephroprotective properties of the erythropoietin mimetic peptide and infliximab in kidney ischemia-reperfusion injury in rat

The present study aimed to investigate the protective effects of erythropoietin mimetic peptide (pHBSP) and infliximab on ischemic renal reperfusion injur. The experiment was performed on 70 white male Wistar laboratory rats which received recombinant erythropoietin, pHBSP, and inflixima

Correction of morphofunctional disorders of the cardiovascular system with asialized erythropoietin and arginase II selective inhibitors KUD 974 and KUD 259 in experimental preeclampsia

The aim of the present study was to study the effectiveness of asialized erythropoietin and arginase II selective inhibitors: KUD-259 and KUD-974 in the correction of morphofunctional disorders of the cardiovascular system in experimental preeclampsi

Perfection of the mechanism of planning of innovative activities based on the system-transdisciplinary approach

The possibility of applying transdisciplinary system methodology in the process of developing plans for the innovative development of business entities has been considered. The use of a transdisciplinary systematic approach to innovation planning allows you to use new methodological planning tools, strengthen the systematic nature of planned activities, more clearly define their content and sequence.Various variants of the classification of scientific approaches according to the criterion of the degree of completeness of cognition of the surrounding world have been analysed, the basic transdisciplinary methodological approaches according to the content criteria and possibilities have been compared, such as: the theory of autopoiesis, the theory of chaos and complexity, the theory of fractals, the theory of turbulence and the theory of economic genetics.An important factor in the proposed methodology is the use of the evolutionary property of the development of organizational systems in combination with the possibility of revolutionary transformations at certain stages of development that determine the susceptibility of the organizational system to innovations. In the process of planning innovations, it is only possible to take into account these features of the development of organizational systems using a systemic transdisciplinary methodology.In the process of research, a transdisciplinary tool such as multiplex has been proposed for use, allowing us to determine the duration of the “internal” periods of development of the organizational system and, consequently, increase the validity of planned measures for the implementation of innovations. The use of this tool in the planning process has allowed us to find an approach to determining the duration of the periods of the various stages of the innovation process, which can in future provide an opportunity to effectively distribute the resources of an economic entity over time. At the same time, special attention in the process of planning investments in the innovation process has been paid to the practice of venture and business angel financing, the positive performance of which has been proved by the example of the United States