Contemporary approaches to assessment of the body's condition of dogs with gastrointestinal pathologies based on the intensity of the inflammato-ry process and the level of endogenous intoxication

Due to the existing methods of diagnosing diseases of domestic animals are ineffective and imperfect, our goal was to develop a technology for assessing the state of the body of dogs to be able to diagnose the occurrence of diseases at an early stage. The article provides data on the development of technology to assess the state of the body, as well as to check its functioning in practice by determining the presence of such typical pathological processes (TPP) as inflammation and endogenous intoxication of the German Shepherd dogs. Clinical, laboratory, and statistical methods were used for the study. As a result of the study, an effective method of assessing the condition of the dog's body was developed and based on two algorithms for determining the intensity of the inflammatory process and endogenous intoxication. This method is effective, sensitive, and fully reproducible in practice, which allows the veterinarian to correctly diagnose and effectively carry out therapy and rehabilitation of sick animals

Біорегуляційний підхід в стимуляції спортивних коней

The presented work presents the results of the effectiveness of the bioregulatory approach in stimulating sports horses. The aim of the study was to find a way to safely restore the energy balance and prevent the occurrence of inflammatory processes in the musculoskeletal system during significant physical exertion. Sport horses spend a lot of energy not only in competition, but also during daily training. Such loads require a high supply of energy. Often the body uses its last reserves to compensate for its energy needs, which leads to exhaustion and the appearance of various diseases. First of all, diseases occur in the musculoskeletal system, because it is the limbs that bear the greatest load during training. As you know, various synthetic doping is introduced to keep animals in a sporty tone. Their action is not long-lasting, but it has many side effects for the animal's body and leads to disruption of the functioning of organs and systems. Today, there is an alternative to such stimulation methods thanks to a bioregulatory approach in the treatment of animals using preparations containing exclusively natural ingredients. To confirm the effectiveness of the use of bioregulatory drugs, clinical and laboratory studies of animal blood (general, biochemical, cytochemical) were carried out. The main changes in laboratory parameters were obtained by cytochemical analysis of such enzymes as GPDH, SDH. These enzymes are among the main indicators of the intensity of energy metabolism in the horse's body. The quantitative composition of basophils and eosinophils has also changed, which indicates a decrease in the level of the inflammatory process in the body of experimental animals. The results obtained prove the effectiveness of the investigated drugs and their direct influence on the energy balance of the “horse-athlete”. Thanks to the natural composition of the components of the preparations used, side effects on the body can be avoided and used without restrictions throughout the horse's sports career.У даній роботі викладені результати ефективності біорегуляційного підходу в стимуляції спортивних коней. Метою дослідження був пошук шляху безпечного відновлення енергетичного балансу та запобігання виникненню запальних процесів в опорно-руховому апараті при значних фізичних навантаженнях. Спортивні коні затрачають багато енергії не тільки на змаганнях, а й під час щоденних тренінгів. Такі навантаження вимагають високого забезпечення енергією. Часто організм, аби компенсувати свої енергетичні потреби, використовує останні резерви, що веде до виснаження та появи різних захворювань. Насамперед захворювання виникають в опорно-руховому апараті, адже саме на кінцівки припадає найбільше навантаження під час тренувань. Для підтримання тварин в спортивному тонусі вводять різні синтетичні допінги. Їхня дія нетривала, проте має багато побічних наслідків для організму коня та призводить до порушення роботи органів і систем. Нині є альтернатива таким методам стимуляції завдяки біорегуляційному підходу у лікуванні тварин з використанням препаратів, що містять виключно натуральні компоненти. Для підтвердження ефективності застосування біорегуляційних препаратів були проведені клінічні та лабораторні дослідження крові тварин (загальні, біохімічні, цитохімічні). Головні зміни в показниках були отримані при цитохімічному аналізі таких ферментів, як ГФДГ, СДГ. Ці ензими є одними з основних показників інтенсивності енергетичного обміну в організмі коней. Також змінився кількісний склад базофілів та еозинофілів, що свідчить про зниження рівня запального процесу в організмі піддослідних тварин. Отримані результати доводять ефективність досліджуваних препаратів та їхній прямий вплив на енергетичний баланс “коня-спортсмена”. Завдяки натуральному складу компонентів застосовуваних препаратів можна уникнути побічного впливу на організм та без обмежень використовувати протягом всієї спортивної кар’єри коня

The BNO-LNGS joint measurement of the solar neutrino capture rate in 71Ga

We describe a cooperative measurement of the capture rate of solar neutrinos by the reaction 71Ga(\nu_e,e^-)71Ge. Extractions were made from a portion of the gallium target in the Russian-American Gallium Experiment SAGE and the extraction samples were transported to the Gran Sasso laboratory for synthesis and counting at the Gallium Neutrino Observatory GNO. Six extractions of this type were made and the resultant solar neutrino capture rate was 64 ^{+24}_{-22} SNU, which agrees well with the overall result of the gallium experiments. The major purpose of this experiment was to make it possible for SAGE to continue their regular schedule of monthly solar neutrino extractions without interruption while a separate experiment was underway to measure the response of 71Ga to neutrinos from an 37Ar source. As side benefits, this experiment proved the feasibility of long-distance sample transport in ultralow background radiochemical experiments and familiarized each group with the methods and techniques of the other.Comment: 7 pages, no figures; minor additions in version

Measurement of the Solar Neutrino Capture Rate by the Russian-American Gallium Solar Neutrino Experiment During One Half of the 22-Year Cycle of Solar Activity

We present the results of measurements of the solar neutrino capture rate in gallium metal by the Russian-American Gallium Experiment SAGE during slightly more than half of a 22-year cycle of solar activity. Combined analysis of the data of 92 runs during the 12-year period January 1990 through December 2001 gives a capture rate of solar neutrinos with energy more than 233 keV of 70.8 +5.3/-5.2 (stat.) +3.7/-3.2 (syst.) SNU. This represents only slightly more than half of the predicted standard solar model rate of 128 SNU. We give the results of new runs beginning in April 1998 and the results of combined analysis of all runs since 1990 during yearly, monthly, and bimonthly periods. Using a simple analysis of the SAGE results combined with those from all other solar neutrino experiments, we estimate the electron neutrino pp flux that reaches the Earth to be (4.6 +/- 1.1) E10/(cm^2-s). Assuming that neutrinos oscillate to active flavors the pp neutrino flux emitted in the solar fusion reaction is approximately (7.7 +/- 1.8) E10/(cm^2-s), in agreement with the standard solar model calculation of (5.95 +/- 0.06) E10/(cm^2-s).Comment: English translation of article submitted to Russian journal Zh. Eksp. Teor. Fiz. (JETP); 12 pages, 5 figures. V2: Added winter-summer difference and 2 reference

Simulations of M87 and Sgr A* imaging with the Millimetron Space Observatory on near-Earth orbits

High resolution imaging of supermassive black holes shadows is a direct way to verify the theory of general relativity at extreme gravity conditions. Very Long Baseline Interferometry (VLBI) observations at millimeter/sub-millimeter wavelengths can provide such angular resolution for supermassive black holes, located in Sgr A* and M87. Recent VLBI observations of M87 with the Event Horizon Telescope (EHT) has shown such capabilities. The maximum obtainable spatial resolution of EHT is limited by Earth diameter and atmospheric phase variations. In order to improve the image resolution longer baselines are required. Radioastron space mission has successfully demonstrated the capabilities of Space-Earth VLBI with baselines much larger than Earth diameter. Millimetron is a next space mission of the Russian Space Agency that will operate at millimeter wavelengths. Nominal orbit of the observatory will be located around Lagrangian L2 point of the Sun-Earth system. In order to optimize the VLBI mode, we consider a possible second stage of the mission that could use near-Earth high elliptical orbit (HEO). In this contribution a set of near-Earth orbits is used for the synthetic space-ground VLBI observations of Sgr A* and M87 in joint Millimetron and EHT configuration. General-relativistic magnetohydrodynamic models (GRMHD) for black hole environment of Sgr A* and M87 are used for static and dynamic imaging simulations at 230 GHz. A comparison preformed between ground and space-ground baselines demonstrates that joint observations with Millimetron and EHT significantly improve the image resolution and allow the EHT+Millimetron to obtain snapshot images of Sgr A* probing dynamics at fast timescales.Comment: 12 pages, 6 figure

Measurement of the solar neutrino capture rate by SAGE and implications for neutrino oscillations in vacuum

The Russian-American solar neutrino experiment has measured the capture rate of neutrinos on metallic gallium in a radiochemical experiment at the Baksan Neutrino Observatory. Eight years of measurement give the result 67.2 (+7.2,-7.0) (+3.5,-3.0) SNU, where the uncertainties are statistical and systematic, respectively. The restrictions these results impose on vacuum neutrino oscillation parameters are given

Measurement of the solar neutrino capture rate with gallium metal

The solar neutrino capture rate measured by the Russian-American Gallium Experiment (SAGE) on metallic gallium during the period January 1990 through December 1997 is 67.2 (+7.2-7.0) (+3.5-3.0) SNU, where the uncertainties are statistical and systematic, respectively. This represents only about half of the predicted Standard Solar Model rate of 129 SNU. All the experimental procedures, including extraction of germanium from gallium, counting of 71Ge, and data analysis are discussed in detail.Comment: 34 pages including 14 figures, Revtex, slightly shortene

Measurement of the solar neutrino capture rate by SAGE and implications for neutrino oscillations in vacuum

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