999 research outputs found
Antibacterial activity of diff erent solvent extracts of Caulerpa chemnitzia (Esper) J.V. Lamououx, from Mandapam, Gulf of Mannar Southeast Coast, Tamil Nadu, India
Phytochemical analyses and in vitro antibacterial activity of different extracts of hexane, chloroform, ethyl acetate,acetone, and methanol extracts of green algae, Caulerpa chemnitzia (Esper) J.V. Lamououx, against Bacillussubtilis, Streptococcus pyogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris,Pseudomonas aeruginosa, Salmonella typhimurium, Shigella flexneri, and Vibrio cholerae. The extent of theinhibitory zone, Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) weredetermined. The ethyl acetate extract of C. chemnitzia showed the presence of phytochemicals, terpenoids,tannins and phenolic compounds strongly than the other solvent extracts. The mean zone of inhibition producedby the extracts in agar diffusion assays against the tested bacterial strains ranged from 7.1 to 13.6 mm. The MICwas between 125 and 500 μg/mL while the MBC were between 250 and 1000 μg/mL. The highest mean zoneof inhibition (13.6 mm) and the lowest MIC (125 μg/mL) and MBC (250 μg/mL) values were observed in ethylacetate extract against B. subtilis. These findings suggest that the ethyl acetate extract of C. chemnitzia can beused as an antibacterial substance for the treatment of bacteria causing acquired infection
Screening of phytochemical and antibacterial potential of diff erent organic solvent extracts of Stoechospermum marginatum (Ag) Kutz. from Manappad coast, Tuticorin District, South India
The antibacterial activity of different extracts of hexane, chloroform, ethyl acetate, acetone and methanol extractof a brown alga, Stoechospermum marginatum (Ag) Kutz. against Bacillus subtilis, Streptococcus pyogenes,Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Salmonellatyphimurium, Shigella flexneri and Vibrio cholerae. The extent of the inhibitory zone, Minimum InhibitoryConcentration (MIC) and Minimum Bactericidal Concentration (MBC) were determined. The ethyl acetateextract of S. marginatum showed the highest antibacterial activity against all the bacterial strains tested thanthe other extracts. The mean zones of inhibition produced by the extracts in agar diffusion assays against thetested bacterial strains ranged from 7.1 to 18.1 mm. The MIC were between 125 and 500 μg/ml, while theMBC were between 250 and 1000 μg/ml. The ethyl acetate extract of S. marginatum showed the presenceof terpenoids, tannins, phenolic compounds and steroids strongly than the other solvent extracts. The highestmean of zone inhibition (18.1 mm) was observed in the ethyl acetate extract of S. marginatum against B. subtilis.These finding suggest that the ethyl acetate extract of S. marginatum can be used as an antibacterial substancefor the treatment of bacterial infections
Topological Transitions in Metamaterials
The ideas of mathematical topology play an important role in many aspects of
modern physics - from phase transitions to field theory to nonlinear dynamics
(Nakahara M (2003) in Geometry, Topology and Physics, ed Brewer DF (IOP
Publishing Ltd, Bristol and Philadelphia), Monastryskiy M (1987) in Riemann
Topology and Physics, (Birkhauser Verlag AG)). An important example of this is
the Lifshitz transition (Lifshitz IM (1960) Anomalies of electron
characteristics of a metal in the high-pressure region, Sov Phys JETP 11:
1130-1135), where the transformation of the Fermi surface of a metal from a
closed to an open geometry (due to e.g. external pressure) leads to a dramatic
effect on the electron magneto-transport (Kosevich AM (2004) Topology and
solid-state physics. Low Temp Phys 30: 97-118). Here, we present the optical
equivalent of the Lifshitz transition in strongly anisotropic metamaterials.
When one of the components of the dielectric permittivity tensor of such a
composite changes sign, the corresponding iso-frequency surface transforms from
an ellipsoid to a hyperboloid. Since the photonic density of states can be
related to the volume enclosed by the iso-frequency surface, such a topological
transition in a metamaterial leads to a dramatic change in the photonic density
of states, with a resulting effect on every single physical parameter related
to the metamaterial - from thermodynamic quantities such as its equilibrium
electromagnetic energy to the nonlinear optical response to
quantum-electrodynamic effects such as spontaneous emission. In the present
paper, we demonstrate the modification of spontaneous light emission from
quantum dots placed near the surface of the metamaterial undergoing the
topological Lifshitz transition, and present the theoretical description of the
effect
Vertical distribution of aerosols over the east coast of India inferred from airborne LIDAR measurements
The information on altitude distribution of aerosols in the atmosphere is essential in assessing the impact of aerosol warming on thermal structure and stability of the atmosphere. In addition, aerosol altitude distribution is needed to address complex problems such as the radiative interaction of aerosols in the presence of clouds. With this objective, an extensive, multi-institutional and multi-platform field experiment (ICARB-Integrated Campaign for Aerosols, gases and Radiation Budget) was carried out under the Geosphere Biosphere Programme of the Indian Space Research Organization (ISRO-GBP) over continental India and adjoining oceans during March to May 2006. Here, we present airborne LIDAR measurements carried out over the east Coast of the India during the ICARB field campaign. An increase in aerosol extinction (scattering + absorption) was observed from the surface upwards with a maximum around 2 to 4 km. Aerosol extinction at higher atmospheric layers (>2 km) was two to three times larger compared to that of the surface. A large fraction (75-85%) of aerosol column optical depth was contributed by aerosols located above 1 km. The aerosol layer heights (defined in this paper as the height at which the gradient in extinction coefficient changes sign) showed a gradual decrease with an increase in the offshore distance. A large fraction (60-75%) of aerosol was found located above clouds indicating enhanced aerosol absorption above clouds. Our study implies that a detailed statistical evaluation of the temporal frequency and spatial extent of elevated aerosol layers is necessary to assess their significance to the climate. This is feasible using data from space-borne lidars such as CALIPSO, which fly in formation with other satellites like MODIS AQUA and MISR, as part of the A-Train constellation
Susceptibility baselines for the invasive mealybugs Phenacoccus manihoti and Paracoccus marginatus (Hemiptera: Pseudococcidae) in cassava ecosystem against selected neonicotinoid insecticides
In recent years, an invasive cassava mealybug Phenacoccus manihoti has been threatening cassava cultivation alongside another invasive papaya mealybug Paracoccus marginatus which invaded the country more than a decade ago. In order to evaluate their responses against the commonly used neonicotinoid insecticides: thiamethoxam 25 WG and imidacloprid 17.8 SL,  acute toxicity experiments to determine the susceptibility baselines in populations of two invasive mealybugs in the cassava agro-ecosystem, namely, cassava mealybug P. manihoti and papaya mealybug P. marginatus were performed upto 15 generations. A systemic uptake method was used for the bioassay. The LC50 values of thiamethoxam for F1 generation were 3.298 ppm whereas it was 1.066 ppm for F15 in cassava mealybug. The LC50 values of F1 generation were 2.014 ppm and that of F15 generation was 1.384 ppm when tested with imidacloprid. In the case of papaya mealybug, the LC50 values ranged from 6.138 ppm (F1) to 2.503 ppm (F15) for thiamethoxam and 7.457 ppm (F1) to 3.231 ppm (F15) for imidacloprid. All the susceptibility indices calculated were less than threefold. The rate of resistance development was negative in all cases showing that none of the tested populations harboured any resistance without insecticidal selection pressure. Tentative discriminating doses were fixed for both chemicals with the help of LC95 values obtained from the bioassay experiments, namely five ppm for both thiamethoxam and imidacloprid in the case of cassava mealybug and 10 ppm and 15 ppm, respectively, for thiamethoxam and imidacloprid in the case of papaya mealybug.         Â
Radiative forcing by aerosols over the Bay of Bengal region derived from shipborne, island-based, and satellite (moderate-resolution imaging spectroradiometer) observations
Measurements of spectral aerosol optical depths (AODs) were made over the Bay of Bengal region (adjacent to the Indian landmass) on board the oceanographic research vessel Sagar Kanya during February 2003. Simultaneous measurements of spectral AODs and mass concentrations of the composite aerosols and aerosol black carbon (BC) were made at an island location, Port Blair (11.63°N, 92.71°E), also in the Bay of Bengal. At the cruise locations the AODs were in the range of ~0.3-0.6 at 500 nm (with a mean value of 0.41 ± 0.14) and Angstrom wavelength exponent of ~1.1 ± 0.1; while at Port Blair the AODs were in the range of 0.11-0.48 at 500 nm and Angstrom wavelength exponent of 0.98 ± 0.07. Aerosol BC constituted 5.8 ± 0.6% of the composite aerosol mass concentration with a single-scattering albedo of ~0.88, indicating the presence of a significant amount of submicron absorbing aerosols. Comparisons of AODs measured at Port Blair during cruise 188 and an earlier cruise (cruise 161B) during March 2001 (over the Bay of Bengal, Arabian Sea, and Indian Ocean) with those derived from Moderate-Resolution Imaging Spectroradiometer (MODIS) (on board the TERRA platform) showed excellent agreement with a mean difference of ~0.01 and a root-meansquare difference of ~0.03. Regionally averaged aerosol (net) forcing over the Bay of Bengal was in the range -15 to -24 W m-2 at the surface and -2 to -4 W m-2 at the top of the atmosphere in February 2003; these values were smaller in magnitude than those observed over this region during March 2001 and larger than that observed over the Arabian Sea and the Indian Ocean. The resulting atmospheric heating due to aerosol absorption was ~0.5°K/d
New limit for the half-life of double beta decay of Zr to the first excited state of Mo
Neutrinoless Double Beta Decay is a phenomenon of fundamental interest in
particle physics. The decay rates of double beta decay transitions to the
excited states can provide input for Nuclear Transition Matrix Element
calculations for the relevant two neutrino double beta decay process. It can be
useful as supplementary information for the calculation of Nuclear Transition
Matrix Element for the neutrinoless double beta decay process. In the present
work, double beta decay of Zr to the excited state of
Mo at 871.1 keV is studied using a low background 230 cm HPGe
detector. No evidence of this decay was found with a 232 g.y exposure of
natural Zirconium. The lower half-life limit obtained for the double beta decay
of to the excited state of is y at 90% C.L., an improvement by a factor of
4 over the existing experimental limit at 90\% C.L. The sensitivity is
estimated to be y at 90% C.L. using
the Feldman-Cousins method.Comment: 11 pages, 7 figures, Accepted in Eur. Phys. J.
Randomized trial of two different conditioning regimens for bone marrow transplantation in thalassemia - the role of busulfan pharmacokinetics in determining outcome
In total, 94 patients with homozygous beta thalassemia were randomized to two different conditioning regimens: busulfan 600 mg/m2+cyclophosphamide 200 mg/kg or busulfan 16 mg/kg+cyclophosphamide 200 mg/kg and antilymphocyte globulin (47 in each group), for bone marrow transplantation, to see whether increased myeloablation or increased immunosuppression would reduce rejection. Busulfan pharmacokinetics in determining outcome was evaluated. There was no significant difference in engraftment, graft-versus-host disease, rejection, and overall and disease-free survival in the two groups. Systemic exposure to busulfan was significantly higher in the 600 mg/m2 group, but in both groups there was a wide interindividual variation in the busulfan kinetics. Six patients rejected the graft, two in the busulfan 600 mg group and four in busulfan 16 mg group (P=0.677 CI -0.17, 0.07), but in five patients (pharmacokinetic data not available in one patient) who rejected the graft busulfan first dose trough level (Cmin-1) was below 150 ng/ml while it was above this level in the 66 of 68 patients with successful engraftment (P0.001). This randomized trial shows that rejection is influenced by busulfan levels and suggests that monitoring of busulfan levels and dose adjustment based on first-dose kinetics may reduce the risk of rejection
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