Water quality issues in the Illinois River watershed: A proposal for new voluntary incentives

Concerns about water quality degradation exist in Northwest Arkansas. The purpose of this study was to analyze the potential usefulness of U.S. conservation programs in addressing water quality concerns on farms in the Illinois River watershed as well as greater Washington County, Arkansas. It was hypothesized that neither the Environmental Quality Incentives Program (EQIP) nor the Conservation Security Program (CSP) in their current forms effectively assists farmers in meeting water-quality management goals. That hypothesis was tested by 1) examining agricultural characteristics of the watershed, 2) actual adoption of EQIP and CSP in Washington County and Arkansas, and, 3) identifying factors that influence program adoption. Results show that based on watershed and farmer characteristics, neither program can meet water quality goals for the region. EQIP adoption is hindered by high rejection rates of applications and farmer dissatisfaction with the program. CSP adoption is unlikely because it does not consider watersheds with degraded water quality and allowable best management practices (BMPs) do not include those related to waste management – precisely the practices most often used by these watershed farmers. Suggestions are offered to modify both EQIP and CSP and use them as a two-part plan to better serve the needs of farmers and improve both adoption rates of BMPs by farmers and water quality in the region

Living Globe: Tridimensional interactive visualization of world demographic data

This paper presents Living Globe, an application for visualization of demo- graphic data supporting the temporal comparison of data from several countries represented on a 3D globe. Living Globe allows the visual exploration of the following demographic data: total population, population density and growth, crude birth and death rates, life expectancy, net migration and population per- centage of different age groups. While offering unexperienced users a default mapping of these data variables into visual variables, Living Globe allows more advanced users to select the mapping, increasing its flexibility. The main aspects of the Living Globe model and prototype are described as well as the evaluation results obtained using heuristic evaluation and usability testing. Some conclusions and ideas for future work are also presented.Comment: 11 pages, 6 figures, submitted to HCII 2016 Conference (Toronto, Canada), published on Human Interface and the Management of Information: Information, Design and Interaction Volume 9734 of the series Lecture Notes in Computer Science, pages 14-2

Thinking in stories

This thesis considers cognitive narrative a component of intelligence that specializes in generality. In exploring the ubiquitous external (mediated) and internal (cognitive) functions of narrative it provides two contributions to the literature: a uniquely cross-discipline survey of narratology that bridges humanities, social science, and computational fields; and a theory to generate cognitive personal narratives from ongoing perception. The implications of narrative cognition and cognitive narrative are discussed as well as the limitations of this introductory theory and the grounds for promising future work.M.S

Both Trait and State Mindfulness Predict Lower Aggressiveness via Anger Rumination: a Multilevel Mediation Analysis

Trait mindfulness, or the capacity for nonjudgmental, present-centered attention, predicts lower aggression in cross-sectional samples, an effect mediated by reduced anger rumination. Experimental work also implicates state mindfulness (i.e., fluctuations around one's typical mindfulness) in aggression. Despite evidence that both trait and state mindfulness predict lower aggression, their relative impact and their mechanisms remain unclear. Higher trait mindfulness and state increases in mindfulness facets may reduce aggression-related outcomes by (1) limiting the intensity of anger, or (2) limiting rumination on anger experiences. The present study tests two hypotheses: First, that both trait and state mindfulness contribute unique variance to lower aggressiveness, and second, that the impact of both trait and state mindfulness on aggressiveness will be uniquely partially mediated by both anger intensity and anger rumination. 86 participants completed trait measures of mindfulness, anger intensity, and anger rumination, then completed diaries for 35 days assessing mindfulness, anger intensity, anger rumination, anger expression, and self-reported and behavioral aggressiveness. Using multilevel zero-inflated regression, we examined unique contributions of trait and state mindfulness facets to daily anger expression and aggressiveness. We also examined the mediating roles of anger intensity and anger rumination at both trait and state levels. Mindfulness facets predicted anger expression and aggressiveness indirectly through anger rumination after controlling for indirect pathways through anger intensity. Individuals with high or fluctuating aggression may benefit from mindfulness training to reduce both intensity of and rumination on anger

An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells.

Duchenne muscular dystrophy is a progressive and incurable neuromuscular disease caused by genetic and biochemical defects of the dystrophin-glycoprotein complex. Here we show the regenerative potential of myogenic progenitors derived from corrected dystrophic induced pluripotent stem cells generated from fibroblasts of mice lacking both dystrophin and utrophin. We correct the phenotype of dystrophic induced pluripotent stem cells using a Sleeping Beauty transposon system carrying the micro-utrophin gene, differentiate these cells into skeletal muscle progenitors and transplant them back into dystrophic mice. Engrafted muscles displayed large numbers of micro-utrophin-positive myofibers, with biochemically restored dystrophin-glycoprotein complex and improved contractile strength. The transplanted cells seed the satellite cell compartment, responded properly to injury and exhibit neuromuscular synapses. We also detect muscle engraftment after systemic delivery of these corrected progenitors. These results represent an important advance towards the future treatment of muscular dystrophies using genetically corrected autologous induced pluripotent stem cells

Estradiol variability, stressful life events, and the emergence of depressive symptomatology during the menopausal transition

To examine the role of estradiol fluctuation in triggering depressive symptoms in the menopause transition and assess the role of recent very stressful life events (VSLEs) as a moderating factor in this relationship

Western North Pacific Tropical Cyclone Tracks in CMIP5 Models: Statistical Assessment Using a Model-Independent Detection and Tracking Scheme

Past studies have shown that tropical cyclone (TC) projection results can be sensitive to different types of TC tracking schemes, and that the relative adjustments of detection criteria to accommodate different models may not necessarily provide a consistent platform for comparison of projection results. Here, future climate projections of TC activity in the western North Pacific basin (WNP, defined from 0°–50°N and 100°E–180°) are assessed with a model-independent detection and tracking scheme. This scheme is applied to models from phase 5 of the Coupled Model Intercomparison Project (CMIP5) forced under the historical and representative concentration pathway 8.5 (RCP8.5) conditions. TC tracks from the observed records and independent models are analyzed simultaneously with a curve-clustering algorithm, allowing observed and model tracks to be projected onto the same set of clusters (k = 9). Four of the nine clusters were projected to undergo significant changes in TC frequency. Straight-moving TCs in the South China Sea were projected to significantly decrease. Projected increases in TC frequency were found poleward of 20°N and east of 160°E, consistent with changes in ascending motion, as well as vertical wind shear and relative humidity respectively. Projections of TC track exposure indicated significant reductions for southern China and the Philippines and significant increases for the Korean peninsula and Japan, although very few model TCs reached the latter subtropical regions in comparison to the observations. The use of a fundamentally different detection methodology that overcomes the detector/tracker bias gives increased certainty to projections as best as low-resolution simulations can offer

QMPSF is sensitive and specific in the detection of NPHP1 heterozygous deletions

BACKGROUND: Nephronophthisis, an autosomal recessive nephropathy, is responsible for 10% of childhood chronic renal failure. The deletion of its major gene, NPHP1, with a minor allele frequency of 0.24% in the general population, is the most common mutation leading to a monogenic form of childhood chronic renal failure. It is challenging to detect it in the heterozygous state. We aimed to evaluate the sensitivity and the specificity of the quantitative multiplex PCR of short fluorescent fragments (QMPSF) in its detection. METHODS: After setting up the protocol of QMPSF, we validated it on 39 individuals diagnosed by multiplex ligation-dependent probe amplification (MLPA) with normal NPHP1 copy number (n=17), with heterozygous deletion (n=13, seven parents and six patients), or with homozygous deletion (n=9). To assess the rate of the deletions that arise from independent events, deleted alleles were haplotyped. RESULTS: The results of QMPSF and MLPA correlated perfectly in the identification of 76 heterozygously deleted and 56 homozygously deleted exons. The inter-experimental variability of the dosage quotient obtained by QMPSF was low: control, 1.05 (median; range, 0.86-1.33, n = 102 exons); heterozygous deletion, 0.51 (0.42-0.67, n = 76 exons); homozygous deletion, 0 (0-0, n = 56 exons). All patients harboring a heterozygous deletion were found to carry a hemizygous mutation. At least 15 out of 18 deletions appeared on different haplotypes and one deletion appeared de novo. CONCLUSIONS: The cost- and time-effective QMPSF has a 100% sensitivity and specificity in the detection of NPHP1 deletion. The potential de novo appearance of NPHP1 deletions makes its segregation analysis highly recommended in clinical practice

Histories of abuse predict stronger within-person covariation of ovarian steroids and mood symptoms in women with menstrually related mood disorder

Individual differences in sensitivity to cyclical changes in ovarian steroids estradiol (E2) and progesterone (P4) have been implicated in the pathophysiology of menstrually related mood disorder (MRMD). However, no prospective studies have investigated psychosocial risk factors for sensitivity to hormone effects on mood in MRMD. Using a repeated measures approach and multilevel models, we tested the hypothesis that a history of abuse provides a context in which within-person elevations of E2 and P4 prospectively predict daily symptoms