Prosocial behavior and altruism: A review of concepts and definitions

The field of prosociality is flourishing, yet researchers disagree about how to define prosocial behavior and often neglect defining it altogether. In this review, we provide an overview about the breadth of definitions of prosocial behavior and the related concept of altruism. Common to almost all definitions is an emphasis on the promotion of welfare in agents other than the actor. However, definitions of the two concepts differ in terms of whether they emphasize intentions and motives, costs and benefits, and the societal context. In order to improve on the conceptual ambiguity surrounding the study of prosociality, we urge researchers to provide definitions, to use operationalizations that match their definitions, and to acknowledge the diversity of prosocial behavior

The dark core of personality and socially aversive psychopathology

Objective: Although dark traits as studied in mainstream personality research and socially aversive psychopathology as studied in abnormal psychology intend to account for the same classes of behavior, their degree of conceptual and, consequently, empirical correspondence has remained limited at best. We aim to overcome this divide by demonstrating clear convergence between the common core of all dark traits (the Dark Factor of Personality, D) and the four prominent instances of socially aversive psychopathology: narcissistic, antisocial, paranoid, and borderline tendencies. Method: In a large-scale, eight-month longitudinal study we assessed D, basic personality (the six HEXACO dimensions), and narcissistic, antisocial, paranoid, and borderline tendencies at time 1 (N = 2,329) and the latter aversive tendencies again at time 2 (N = 668) using different inventories. Results: D predicted all instances of socially aversive psychopathology cross-sectionally and longitudinally, with a large effect size on average, beyond the six HEXACO dimensions and even beyond the very same instances (measured through a different inventory). Conclusions: Bridging mainstream personality and abnormal psychology, the findings reveal strong, theory-consistent correspondence between dark traits and socially aversive psychopathology once dark traits are viewed through the lens of their common core, D

Shot noise in tunneling transport through molecules and quantum dots

We consider electrical transport through single molecules coupled to metal electrodes via tunneling barriers. Approximating the molecule by the Anderson impurity model as the simplest model which includes Coulomb charging effects, we extend the ``orthodox'' theory to expand current and shot noise systematically order by order in the tunnel couplings. In particular, we show that a combined measurement of current and shot noise reveals detailed information of the system even in the weak-coupling limit, such as the ratio of the tunnel-coupling strengths of the molecule to the left and right electrode, and the presence of the Coulomb charging energy. Our analysis holds for single-level quantum dots as well.Comment: 8 page

Management of perioperative bleeding risk in patients on antithrombotic medications undergoing cardiac surgery—a systematic review

Background: Antithrombotic drugs increase the risk of bleeding, especially in patients who need urgent surgery without an adequate wash-out period. This review aims to evaluate perioperative bleeding complications in patients on dual antiplatelet therapy (DAPT) or direct-acting oral anticoagulants (DOACs) undergoing high-bleeding risk cardiovascular surgery and to present currently available potential solutions to mitigate antithrombotic therapy-related bleeding complications. Methods: As a first step, we searched for relevant articles, over the last 10 years, in Medline (PubMed) and abstracted clinical information based on pre-defined criteria for bleeding complications. In the next step, an additional search evaluating potential solutions to mitigate bleeding complications was performed. The literature screening and selection process followed the principles derived from the PRISMA statement. Results: From all reviewed studies, a total of 19 articles could be included evaluating the risk for bleeding in cardiac surgery related to DAPT or DOACs and 10 papers evaluating antithrombotic drug reversal or removal in the setting of cardiovascular surgery. Reported bleeding rates ranged between 18% and 41%. The variability of the reported data is remarkable. Idarucizumab is reported to provide optimal perioperative hemostasis in up to 93% of patients. It has been observed that andexanet alfa causes unresponsiveness to the anticoagulant effects of heparin. Antithrombotic removal by intraoperative hemoadsorption is found to be associated with a significant decrease in re-thoracotomy rate, overall procedure duration, administered transfusion volumes, chest-tube drainage, and length of hospitalization. Discussion: Bleeding complications in patients treated with DAPT or DOACs in cardiac surgery are high. New costly reversal agents are available but have not been sufficiently tested in the cardio-surgical setting so far. Interestingly, bleeding-related complications seem to be effectively reduced by applying innovative intraoperative hemoadsorption techniques. Expected results from the ongoing trials should provide better insights concerning the efficacy and safety of several potential solutions. Currently, the variability of reports and the deficit of high-quality studies in this specific setting represent the major limitation for the unbiased conclusion of this review

Generation of RF Frequency and Phase References on the FAIR Site

Based on the Bunch Phase Timing System (BuTiS) local analog radio frequency reference signals (RF references) like the particle revolution frequency and their multiple harmonics will be generated. These references are used to control the phase of the accelerator cavities to altering harmonics of the bunch revolution frequency. Delay or phase shifts from the FAIR-Center to references at the BuTiS endpoints are already compensated by the BuTiS receivers. Phase shifts from the RF reference generators to LLRF electronics can be compensated by controlling the output phases of the DDS modules of the RF references. However phase shift delays of multiple harmonics at the same interconnecting electrical path are not identical at the same time. Configurable electronics manage phase calibration of the RF references to their endpoints. Calibration may depend on frequency and harmonic of the RF reference, aging as well as on thermal effects. The electrical length and impedance of interconnecting cables for phase control loops can be compensated. This is an important feature, in particular if control loops are switched between different harmonic frequencies

Green function techniques in the treatment of quantum transport at the molecular scale

The theoretical investigation of charge (and spin) transport at nanometer length scales requires the use of advanced and powerful techniques able to deal with the dynamical properties of the relevant physical systems, to explicitly include out-of-equilibrium situations typical for electrical/heat transport as well as to take into account interaction effects in a systematic way. Equilibrium Green function techniques and their extension to non-equilibrium situations via the Keldysh formalism build one of the pillars of current state-of-the-art approaches to quantum transport which have been implemented in both model Hamiltonian formulations and first-principle methodologies. We offer a tutorial overview of the applications of Green functions to deal with some fundamental aspects of charge transport at the nanoscale, mainly focusing on applications to model Hamiltonian formulations.Comment: Tutorial review, LaTeX, 129 pages, 41 figures, 300 references, submitted to Springer series "Lecture Notes in Physics

Identification of the Rheumatoid Arthritis Shared Epitope Binding Site on Calreticulin

Background: The rheumatoid arthritis (RA) shared epitope (SE), a major risk factor for severe disease, is a five amino acid motif in the third allelic hypervariable region of the HLA-DRb chain. The molecular mechanisms by which the SE affects susceptibility to – and severity of- RA are unknown. We have recently demonstrated that the SE acts as a ligand that interacts with cell surface calreticulin (CRT) and activates innate immune signaling. In order to better understand the molecular basis of SE-RA association, here we have undertaken to map the SE binding site on CRT. Principal Findings: Surface plasmon resonance (SPR) experiments with domain deletion mutants suggested that the SE binding site is located in the P-domain of CRT. The role of this domain as a SE-binding region was further confirmed by a sulfosuccinimidyl-2-[6-(biotinamido)-2-(p-azido-benzamido) hexanoamido] ethyl-1,3-dithiopropionate (sulfo-SBED) photoactive cross-linking method. In silico analysis of docking interactions between a conformationally intact SE ligand and the CRT P-domain predicted the region within amino acid residues 217–224 as a potential SE binding site. Site-directed mutagenesis demonstrated involvement of residues Glu 217 and Glu 223- and to a lesser extent residue Asp 220- in cell-free SPR-based binding and signal transduction assays. Significance: We have characterized here the molecular basis of a novel ligand-receptor interaction between the SE and CRT. The interaction represents a structurally and functionally well-defined example of cross talk between the adaptive an