97 research outputs found
Single-Particle Green Functions in Exactly Solvable Models of Bose and Fermi Liquids
Based on a class of exactly solvable models of interacting bose and fermi
liquids, we compute the single-particle propagators of these systems exactly
for all wavelengths and energies and in any number of spatial dimensions. The
field operators are expressed in terms of bose fields that correspond to
displacements of the condensate in the bose case and displacements of the fermi
sea in the fermi case.
Unlike some of the previous attempts, the present attempt reduces the answer
for the spectral function in any dimension in both fermi and bose systems to
quadratures.
It is shown that when only the lowest order sea-displacement terms are
included, the random phase approximation in its many guises is recovered in the
fermi case, and Bogoliubov's theory in the bose case. The momentum distribution
is evaluated using two different approaches, exact diagonalisation and the
equation of motion approach.
The novelty being of course, the exact computation of single-particle
properties including short wavelength behaviour.Comment: Latest version to be published in Phys. Rev. B. enlarged to around 40
page
U(1) Gauge Theory as Quantum Hydrodynamics
It is shown that gauge theories are most naturally studied via a polar
decomposition of the field variable. Gauge transformations may be viewed as
those that leave the density invariant but change the phase variable by
additive amounts. The path integral approach is used to compute the partition
function. When gauge fields are included, the constraint brought about by gauge
invariance simply means an appropriate linear combination of the gradients of
the phase variable and the gauge field is invariant. No gauge fixing is needed
in this approach that is closest to the spirit of the gauge principle.
We derive an exact formula for the condensate fraction and in case it is
zero, an exact formula for the anomalous exponent. We also derive a formula for
the vortex strength which involves computing radiation corrections.Comment: 15 pages, Plain LaTeX, final published versio
Polymorphisms within immune regulatory pathways predict cetuximab efficacy and survival in metastatic colorectal cancer patients
Cetuximab, an IgG1 EGFR-directed antibody, promotes antibody-dependent cell-mediated cytotoxicity. We hypothesized that single-nucleotide polymorphisms (SNPs) in immune regulatory pathways may predict outcomes in patients with metastatic colorectal cancer treated with cetuximab-based regimens. A total of 924 patients were included: 105 received cetuximab in IMCL-0144 and cetuximab/irinotecan in GONO-ASL608LIOM01 (training cohort), 225 FOLFIRI/cetuximab in FIRE-3 (validation cohort 1), 74 oxaliplatin/cetuximab regimens in JACCRO CC-05/06 (validation cohort 2), and 520 FOLFIRI/bevacizumab in FIRE-3 and TRIBE (control cohorts). Twelve SNPs in five genes (IDO1; PD-L1; PD-1; CTLA-4; CD24) were evaluated by PCR-based direct sequencing. We analyzed associations between genotype and clinical outcomes. In the training cohort; patients with the CD24 rs52812045 A/A genotype had a significantly shorter median PFS and OS than those with the G/G genotype (PFS 1.3 vs. 3.6 months; OS 2.3 vs. 7.8 months) in univariate (PFS HR 3.62; p = 0.001; OS HR 3.27; p = 0.0004) and multivariate (PFS HR 3.18; p = 0.009; OS HR 4.93; p = 0.001) analyses. Similarly; any A allele carriers in the JACCRO validation cohort had a significantly shorter PFS than G/G carriers (9.2 vs. 11.8 months; univariate HR 1.90; p = 0.011; multivariate HR 2.12; p = 0.018). These associations were not demonstrated in the control cohorts. CD24 genetic variants may help select patients with metastatic colorectal cancer most likely to benefit from cetuximab-based therapy
Volume element structure and roton-maxon-phonon excitations in superfluid helium beyond the Gross-Pitaevskii approximation
We propose a theory which deals with the structure and interactions of volume
elements in liquid helium II. The approach consists of two nested models linked
via parametric space. The short-wavelength part describes the interior
structure of the fluid element using a non-perturbative approach based on the
logarithmic wave equation; it suggests the Gaussian-like behaviour of the
element's interior density and interparticle interaction potential. The
long-wavelength part is the quantum many-body theory of such elements which
deals with their dynamics and interactions. Our approach leads to a unified
description of the phonon, maxon and roton excitations, and has noteworthy
agreement with experiment: with one essential parameter to fit we reproduce at
high accuracy not only the roton minimum but also the neighboring local maximum
as well as the sound velocity and structure factor.Comment: 9 pages, 6 figure
A genetic variant in Rassf1a predicts outcome in mCRC patients treated with cetuximab plus chemotherapy : results from FIRE-3 and JACCRO 05 and 06 trials
The Hippo pathway is involved in colorectal cancer (CRC) development and progression. The Hippo regulator Rassf1a is also involved in the Ras signaling cascade. In this work, we tested single nucleotide polymorphisms within Hippo components and their association with outcome in CRC patients treated with cetuximab. Two cohorts treated with cetuximab plus chemotherapy were evaluated (198 RAS wild-type (wt) patients treated with first-line FOLFIRI plus Cetuximab within the FIRE-3 trial and 67 Ras wt patients treated either with first-line mFOLFOX6 or SOX plus Cetuximab). In these two populations, Rassf1a rs2236947 was associated with overall survival, as patients with a CC genotype had significantly longer OS compared to those with CA or AA genotypes. This association was stronger in patients with left-side CRC [HR: 1.79 (1.01-3.14); P =0.044 and HR: 2.83 (1.14-7.03); P =0.025, for Fire 3 and JACCRO cohorts, respectively]. Rassf1a rs2236947 is a promising biomarker for patients treated with cetuximab plus chemotherapy
Hemokinin-1 Gene Expression Is Upregulated in Microglia Activated by Lipopolysaccharide through NF-ÎşB and p38 MAPK Signaling Pathways
The mammalian tachykinins, substance P (SP) and hemokinin-1 (HK-1), are widely distributed throughout the nervous system and/or peripheral organs, and function as neurotransmitters or chemical modulators by activating their cognate receptor NK1. The TAC1 gene encoding SP is highly expressed in the nervous system, while the TAC4 gene encoding HK-1 is uniformly expressed throughout the body, including a variety of peripheral immune cells. Since TAC4 mRNA is also expressed in microglia, the resident immune cells in the central nervous system, HK-1 may be involved in the inflammatory processes mediated by these cells. In the present study, we found that TAC4, rather than TAC1, was the predominant tachykinin gene expressed in primary cultured microglia. TAC4 mRNA expression was upregulated in the microglia upon their activation by lipopolysaccharide, a well-characterized Toll-like receptor 4 agonist, while TAC1 mRNA expression was downregulated. Furthermore, both nuclear factor-ÎşB and p38 mitogen-activated protein kinase intracellular signaling pathways were required for the upregulation of TAC4 mRNA expression, but not for the downregulation of TAC1 mRNA expression. These findings suggest that HK-1, rather than SP, plays dominant roles in the pathological conditions associated with microglial activation, such as neurodegenerative and neuroinflammatory disorders
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