Induction of Stress Granule Assembly is Essential for the Orchestration of DNA Damage Response

DNA damage provokes several responses including DNA repair, cell cycle regulation and apoptosis that collectively represent the DNA damage response (DDR). Here, we demonstrate that the DDR incorporates the activation of stress granule (SG) formation pathway as a mechanism to process destabilized RNAs. UV irradiation induced the assembly of SGs during the G2 phase and newly formed SGs appeared exclusively in the early G1 phase. SG assembly pathway was activated within the first hours after DNA damage, suggesting that the processing of destabilized RNAs is activated at an early stage. The induction of SGs and RNAi effector protein Argonaute 2 recruitment after UV exposure was independent of ATM and ATR signaling cascades. Apoptosis occurred only in SG-negative cells indicating that SGs promote cell survival after genotoxic stress. Analysis of several DNA damage/repair deficient MEFs revealed that the SG accumulation remained unaltered after UV exposure. Our results show that SGs are an essential component of DDR that is activated in parallel to the DNA damage kinase response networks

A new Miconia (Melastomatacaeae) from Bolivia, with remarks on angular-branched species in the Andes

A new species of Melastomataceae frorm Bolivia is described, illustrated and placed in a phenetic context within Miconia, a genus of 1000 species and about 2000 published names. Miconia quadrialata is readily distinguished from its Congeners by two-colored leaves and sharply four-angular and winged branchlets. A search for quadrangular-branched miconias revealed that 12 of 15 such species (in four sections), including the new species, occur in cloud forest in the Andes, raising the question of the adaptive significance of quadrangular branchlets

Geodesic systems of tunnels in hyperbolic 3-manifolds

It is unknown whether an unknotting tunnel is always isotopic to a geodesic in a finite volume hyperbolic 3-manifold. In this paper, we address the generalization of this problem to hyperbolic 3-manifolds admitting tunnel systems. We show that there exist finite volume hyperbolic 3-manifolds with a single cusp, with a system of at least two tunnels, such that all but one of the tunnels come arbitrarily close to self-intersecting. This gives evidence that systems of unknotting tunnels may not be isotopic to geodesics in tunnel number n manifolds. In order to show this result, we prove there is a geometrically finite hyperbolic structure on a (1;n)-compression body with a system of core tunnels such that all but one of the core tunnels self-intersect.Comment: 19 pages, 4 figures. V2 contains minor updates to references and exposition. To appear in Algebr. Geom. Topo

Research and Development Expenditures of Innovative Enterprises in the Time of Crisis

In an analysed group of enterprises the smallest "resistance" to crisis was observed in American companies. The enterprises from the EU also reduced research and development expenditures but the pace of a fall in these expenditures was smaller than in the case of American companies.W badanej zbiorowości przedsiębiorstw najmniejszą "odporność" na kryzys wykazaly firmy amerykańskie. Firmy wywodzące się z UE również zanotowaly zmniejszenie nakladów na badania i rozwój, jednak tempo spadku nakladów badawczo-rozwojowych bylo tu mniejsze niż w przypadku firm amerykańskich

Global Climate Change and the Equity-Efficiency Puzzle

There is a broad consensus that the costs of abatement of global climate change can be reduced efficiently through the assignment of quota rights, and through international trade in these rights. But there is no consensus on whether the initial assignment of emission permits can affect the Pareto-optimal global level of abatement. This paper provides some insight into the equity-efficiency puzzle. Qualitative results are obtained from a small-scale model, and then quantitative evidence of separability is obtained from MERGE, a multi-region integrated assessment model. It is shown that if all the costs of climate change can be expressed in terms of GDP losses, Pareto-efficient abatement strategies are independent of the initial allocation of emission rights. This is the case sometimes described as "market damages". If, however, different regions assign different values to non-market damages such as species losses, different sharing rules may affect the Pareto-optimal level of greenhouse gas abatement. Separability may then be demonstrated only in specific cases (e.g. identical welfare functions or quasi-linearity of preferences or small shares of wealth devoted to abatement)International climate policy; Global climate change

Stability of freely falling granular streams

A freely falling stream of weakly cohesive granular particles is modeled and analysed with help of event driven simulations and continuum hydrodynamics. The former show a breakup of the stream into droplets, whose size is measured as a function of cohesive energy. Extensional flow is an exact solution of the one-dimensional Navier-Stokes equation, corresponding to a strain rate, decaying like 1/t from its initial value, gammaDot0. Expanding around this basic state, we show that the flow is stable for short times (gammaDot0 * t << 1), whereas for long times (gammaDot0 * t >> 1) perturbations of all wavelength grow. The growthrate of a given wavelength depends on the instant of time when the fluctuation occurs, so that the observable patterns can vary considerably.Comment: 4 page, 5 figures. Submitted to PRL. Supplementary material: see http://wwwuser.gwdg.de/~sulrich/research/#Publication

Political Economists are Neither Selfish Nor Indoctrinated

Most professional economists believe that economists in general are more selfish than other persons and that this greater selfishness is due to economics education. This paper offers empirical evidence against this widely held belief. Using a unique data set about giving behavior in connection with two social funds at the University of Zurich, it is shown that economics education does not make people act more selfishly. Rather, this natural experiment suggests that the particular behavior of economists can be explained by a selection effect.economists, public good, giving behavior, education, selection