How Do Maternal Subclinical Symptoms Influence Infant Motor Development during the First Year of Life?

An unavoidable reciprocal influence characterizes the mother-child dyad. Within this relationship, the presence of depression, somatization, hostility, paranoid ideation, and interpersonal sensitivity symptoms at a subclinical level and their possible input on infant motor competences has not been yet considered. Bearing in mind that motor abilities represent not only an indicator of the infant\u2019s health-status, but also the principal field to infer his/her needs, feelings and intentions, in this study the quality of infants\u2019 movements were assessed and analyzed in relationship with the maternal attitudes. The aim of this research was to investigate if/how maternal symptomatology may pilot infant\u2019s motor development during his/her first year of life by observing the characteristics of motor development in infants aged 0\u201311 months. Participants included 123 mothers and their infants (0\u201311 months-old). Mothers\u2019 symptomatology was screened with the Symptom Checklist-90-Revised (SCL-90-R), while infants were tested with the Peabody Developmental Motor Scale-Second Edition. All dyads belonged to a non-clinical population, however, on the basis of SCL-90-R scores, the mothers\u2019 sample was divided into two groups: normative and subclinical. Descriptive, t-test, correlational analysis between PDMS-2 scores and SCL-90-R results are reported, as well as regression models results. Both positive and negative correlations were found between maternal perceived symptomatology, Somatization (SOM), Interpersonal Sensitivity (IS), Depression (DEP), Hostility (HOS), and Paranoid Ideation (PAR) and infants\u2019 motor abilities. These results were further verified by applying regression models to predict the infant\u2019s motor outcomes on the basis of babies\u2019 age and maternal status. The presence of positive symptoms in the SCL-90-R questionnaire (subclinical group) predicted good visual-motor integration and stationary competences in the babies. In particular, depressive and hostility feelings in mothers seemed to induce an infant motor behavior characterized by a major control of the environmental space. When mothers perceived a higher level of hostility and somatization, their babies showed difficulties in sharing action space, such as required in the development of stationary positions and grasping abilities. In a completely different way, when infants can rely on a mother with low-perceived symptoms (normative group) his/her motor performances develop with a higher degree of freedom/independence. These findings suggest, for the first time, that even in a non- clinical sample, mother\u2019s perceived-symptoms can produce important consequences not in infant motor development as a whole, but in some specific areas, contributing to shape the infant\u2019s motor ability and his/her capability to act in the world

Mothers and fathers with Binge Eating Disorder and their 18-36 months old children: a longitudinal study on parent-infant interactions and offspring\u2019s emotional-behavioral profiles

Maternal Binge Eating Disorder (BED) has been suggested to be associated with poor parent\u2013infant interactions during feeding and with children\u2019s emotional and behavioral problems during infancy (Blissett and Haycraft, 2011). The role of fathers has received increasing consideration in recent years, yet the research has not focused on interactional patterns between fathers with BED and their children. The present study aimed to longitudinally investigate the in\ufb02uence of BED diagnosis, in one or both parents, on parent\u2013infant feeding interactions and on children\u2019s emotional\u2013behavioral functioning. 612 subjects (408 parents; 204 children), recruited in mental health services and pre-schools in Central Italy, were divided into four groups: Group 1 included families with both parents diagnosed with BED, Group 2 and 3 included families with one parent diagnosed with BED, Group 0 was a healthy control. The assessment took place at T1 (18 months of age of children) and T2 (36 months of age of children): feeding interactions were assessed through the Scale for the Assessment of Feeding Interactions (SVIA) while child emotional\u2013behavioral functioning was evaluated with the Child Behavior Check-List (CBCL). When compared to healthy controls, the groups with one or both parents diagnosed with BED showed higher scores on the SVIA and on the CBCL internalizing and externalizing scales, indicating poorer adult\u2013child feeding interactions and higher emotional\u2013behavioral dif\ufb01culties. A direct in\ufb02uence of parental psychiatric diagnosis on the quality of mother\u2013infant and father\u2013infant interactions was also found, both at T1 and T2. Moreover, dyadic feeding interactions mediated the in\ufb02uence of parental diagnosis on children\u2019s psychological functioning. The presence of BED diagnosis in one or both parents seems to in\ufb02uence the severity of maladaptive parent\u2013infant exchanges during feeding and offspring\u2019s emotional\u2013behavioral problems over time, consequently affecting different areas of children\u2019s psychological functioning. This is the \ufb01rst study to demonstrate the speci\ufb01c effects of maternal and paternal BED on infant development. These results could inform prevention and intervention programs in families with one or both parents diagnosed with BED

Mafia and public spending: Evidence on the fiscal multiplier from a quasi-experiment

A law issued to combat political corruption and Mafia infiltration of city councils in Italy has resulted in episodes of large, unanticipated, temporary contractions in local public spending. Using these episodes as instruments, we estimate the output multiplier of spending cuts at provincial level—controlling for national monetary and fiscal policy, and holding the tax burden of local residents constant—to be 1.5. Assuming that lagged spending is exogenous to current output brings the estimate of the overall multiplier up to 1.9. These results suggest that local spending adjustment may be quite consequential for local activity. (JEL D72, E62, H71, K42) The work on this paper is part of PEGGED (Politics, Economics and Global Governance: The European Dimensions), Contract no. SSH7-CT-2008-217559 within the seventh Framework Programme for Research and Technological Development. Support from the Pierre Werner Chair Programme at the European University Institute is also gratefully acknowledged.This is the version of record, which can also be found on the publisher's website at: http://pubs.aeaweb.org/doi/pdfplus/10.1257/aer.104.7.2185 © American Economic Associatio

Local structure of REFeAsO (RE=La, Pr, Nd, Sm) oxypnictides studied by Fe K-edge EXAFS

Local structure of REOFeAs (RE=La, Pr, Nd, Sm) system has been studied as a function of chemical pressure varied due to different rare-earth size. Fe K-edge extended X-ray absorption fine structure (EXAFS) measurements in the fluorescence mode has permitted to compare systematically the inter-atomic distances and their mean square relative displacements (MSRD). We find that the Fe-As bond length and the corresponding MSRD hardly show any change, suggesting the strongly covalent nature of this bond, while the Fe-Fe and Fe-RE bond lengths decrease with decreasing rare earth size. The results provide important information on the atomic correlations that could have direct implication on the superconductivity and magnetism of REOFeAs system, with the chemical pressure being a key ingredient

Perceived maternal symptomatology and its influence on newborn’s motor development. Study on non-clinical mother-infant (1-11 months) dyads.

Introduction: Newborn’s first approach to the world takes place in the relationship with his/her mother. He/she builds his/her-own experiences from mother's repertoire of facial expressions, voices, gestures. Contemporarily, the process of becoming mother entails a wide range of changes, which may lead to psychopathology conditions, among which post-partum depression is the most common. This disease is known to negatively influence maternal abilities and produce feelings of greater struggle in caring the infant, sense of guilty and poor self-efficacy. Motor development represents the principal field of observation in helping to infer infant's needs, feelings and intentions. Its investigation may be a powerful means to understand the influence of maternal attitudes (e.g. depressive-symptoms) on infant motor-development. Aims of the study: The main aim of this research was to investigate the characteristics of motor- development in infants aged 1-11 months, and if/how maternal depressive-symptomatology may influence infant's motor-development during his/her first year of life. Material&Methods: Data were collected within the wider Italian-validation-project of the Peabody Developmental Motor Scale-II (PDMS-2). Participants included 123 infants (1-11 months old) with their mothers. Infants were tested with PDMS-2 and mothers’ symptomatology was screened with SCL-90-TR and CES-D. All dyads belong to non-clinical population. We calculated correlational- and regression-analysis between PDMS-2,SCL-90 and CES-D. Results: The best predictor of infants’ motor-performance is the age in months. Perceived maternal somatization negatively predicted infants’ Fine-Motor-scores. On the contrary, positive correlations were found between depressive perceived symptoms, InterpersonalSensitivity, Hostility and Paranoid Ideation and infants Gross- Motor abilities, especially Locomotion. Conclusions: Results suggest that mother's perceived symptoms influence the ability of the infant to move trough the space, while perceived levels of somatization negatively predict his/her fine- motor development. Age-in-months is the most accurate predictor of motor-performance. Further analyses are needed to better understand relationship between maternal-symptomatology and infant motor-skills

A Martini coarse-grained model of the calcein fluorescent dye

Calcein leakage assays are a standard experimental set-up for probing the extent of damage induced by external agents on synthetic lipid vesicles. The fluorescence signal associated with calcein release from liposomes is the signature of vesicle disruption, transient pore formation or vesicle fusion. This type of assay is widely used to test the membrane disruptive effect of biological macromolecules, such as proteins, antimicrobial peptides and RNA and is also used on synthetic nanoparticles with a polymer, metal or oxide core. Little is known about the effect that calcein and other fluorescent dyes may have on the properties of lipid bilayers, potentially altering their structure and permeability. Here we develop a coarse-grained model of calcein that is compatible with the Martini force field for lipids. We validate the model by comparing its dimerization free energy, aggregation behavior at different concentrations and interaction with a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membrane to those obtained at atomistic resolution. Our coarse-grained description of calcein makes it suitable for the simulation of large calcein-filled liposomes and of their interactions with external agents, allowing for a direct comparison between simulations and experimental liposome leakage assays

Sc substitution for Mg in MgB2: effects on Tc and Kohn anomaly

Here we report synthesis and characterization of Mg_{1-x}Sc_{x}B_{2} (0.12T_{c}>6 K. We find that the Sc doping moves the chemical potential through the 2D/3D electronic topological transition (ETT) in the sigma band where the ``shape resonance" of interband pairing occurs. In the 3D regime beyond the ETT we observe a hardening of the E_{2g} Raman mode with a significant line-width narrowing due to suppression of the Kohn anomaly over the range 0<q<2k_{F}.Comment: 8 pages, 4 EPS figures, to be published in Phys. Rev.

Electric-pulse-induced reversible resistance in doped zinc oxide thin films

Nonvolatile, electric-pulse-induced resistance switching is reported on S and Co doped ZnO thin films deposited on different substrates using magnetron sputtering and laser ablation. Two resistance states were obtained by applying voltage pulses of different polarity. The switching was observed regardless of the substrate, dopant species, or microstructure of the samples. In the Co doped ZnO samples, the two resistance states are remarkably stable and uniform

Microzooplankton grazing and phytoplankton growth in marine mesocosms with increased CO2 levels

Microzooplankton grazing and algae growth responses to increasing pCO2 levels (350, 700 and 1050 μatm) were investigated in nitrate and phosphate fertilized mesocosms during the PeECE III experiment 2005. Grazing and growth rates were estimated by the dilution technique combined with taxon specific HPLC pigment analysis. Microzooplankton composition was determined by light microscopy. Despite a range of up to 3 times the present CO2 levels, there were no clear differences in any measured parameter between the different CO2 treatments. During days 3–9 of the experiment the algae community standing stock, measured as chlorophyll a (Chl-a), showed the highest instantaneous grow rates (k=0.37–0.99 d−1) and increased from ca. 2–3 to 6–12 μg l−1, in all mesocosms. Afterwards the phytoplankton standing stock decreased in all mesocosms until the end of the experiment. The microzooplankton standing stock, that was mainly constituted by dinoflagellates and ciliates, varied between 23 and 130 μg C l−1 (corresponding to 1.9 and 10.8 μmol C l−1), peaking on day 13–15, apparently responding to the phytoplankton development. Instantaneous Chl-a growth rates were generally higher than the grazing rates, indicating only a limited overall effect of microzooplankton grazing on the most dominant phytoplankton. Diatoms and prymnesiophytes were significantly grazed (12–43% of the standing stock d−1) only in the pre-bloom phase when they were in low numbers, and in the post-bloom phase when they were already affected by low nutrients and/or viral lysis. The cyanobacteria populations appeared more affected by microzooplankton grazing which generally removed 20–65% of the standing stock per day