74 research outputs found
Some methodological aspects of conducting and evaluating adult health check-up: a systematic review of regulatory public health documentation in the Russian Federation
Background. The Constitution of the Russian Federation and federal laws define the main postulates of the methodology for preventive measures as a priority in the field of public health. Sectoral regulatory legal acts, namely, orders of the Ministry of Health of Russia present the methodology as a system of principles and methods for organizing preventive activities, including health check-ups of the adult population. The effectiveness of the largest preventive measure of the Russian health care system β health check-ups of certain groups of the adult population β depends on the quality and validity of the methodological provisions of the regulatory legal act.Objective. To assess the completeness and objectivity of methodological approaches to conducting and evaluating medical check-ups of certain groups of the adult population, reflected in regulatory legal acts.Methods. The research methodology involved a systematic review of the regulatory documentation of the Russian Federation in the field of health care from January 2012 to December 2022 to verify the basics of the methodology for conducting and evaluating preventive measures for certain groups of the adult population. The information was searched in the database of the ConsultantPlus legal reference system and on the official website of the Ministry of Health (Russian Federation), as well as in the electronic databases of the CyberLeninka and eLIBRARY.RU scientific electronic libraries. The study involved the methods of content analysis, analytical generalization, analogies, and formalization. Data analysis was focused on the organization of the health check-up of the adult population, the evaluation of its performance and effectiveness in accordance with regulatory legal acts, as well as the assessment of the quality of data obtained during the check-up.Results. A dynamic retrospective study of the regulatory framework, including the orders of the Ministry of Health of Russia, both those that have expired and those that are currently in force, identified methodological shortcomings in conducting and evaluating medical check-ups. The methodology for health check-ups of the adult population is reflected in regulatory acts. However, their number exceeds one or several documents, thereby creating a certain complexity in their interpretation and use in practice. The methodology for assessing and monitoring the implementation of health check-ups appears to be poorly defined, since it is based on a single indicator β coverage of the population with preventive check-ups and clinical examinations, thereby failing to reflect the real effect of the largest preventive measure of the state health care system. The issue requires new methodological approaches to conducting and evaluating health check-ups as a whole. The study and evaluation of check-up results is based on the statistical data analysis with imperfect methodology for collecting the data. This negatively affects the quality of statistical data, thereby leading to inadequate interpretation of the data and, as a result, to erroneous management decisions made at all levels of the executive branch.Conclusion. It is advisable to develop general methodology for conducting medical check-ups, and to consider the feasibility of creating an integral indicator for evaluating them. Specialists in the field of health care, as well as in related fields, should be involved for this purpose. A medical health officer should be assigned to coordinate the development of a methodology for organizing, conducting and evaluating health check-ups
Π€Π°ΡΠΌΠ°ΠΊΠΎΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Ρ ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΡΠΎΠ½Ρ ΠΎΠ² ΠΈ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ
Aim: to conduct a pharmacoeconomic analysis of chemotherapy taking into account the types of malignant neoplasms of the bronchi and lung, and to calculate pharmacoeconomic efficiency.Materials and methods. The materials for the study were the data of the Moscow Cancer Hospital n.a. D.D. Pletnev for 2019. The cost of drugs was calculated according to the data of the website aptekamos.ru (for June 2019).Results and discussion. For 300 patients with squamous non-small cell lung cancer, it is required 3205.5 courses of chemotherapy of I (1747.5) and II (1458) lines. For 200 patients with non-small cell non-squamous EGFR positive lung cancer, it is required 1,413.1 courses of chemotherapy and targeted therapy. For 70 patients with non-squamous cell non-small cell lung cancer with ALK mutation, it is required 450.2 courses of chemotherapy and targeted therapy. For 280 patients with non-squamous cell non-small cell lung cancer lung cancer without mutations, it is required 7515 chemotherapy courses. For 150 patients with small cell lung cancer, it is required 1,656.8 courses of chemotherapy. Thus, a total sample of 1000 patients, excluding the type of malignant neoplasm of broncus and lung are required 14,239.8 chemotherapy courses. The determined cost of 67,000 rubles for the average chemotherapy course per patient takes into account the necessary colony stimulating factors, antiemetic, infusion solutions, etc.; in the case of treatment with erlotinib (the length of the course is 8 months), the cost is 663,408.0 rubles; in the case of treatment with crizotinib (the length of the course is 11 months course), the cost is 2044110.0 rubles. The average cost of drug therapy for one patient with malignant neoplasm of bronchus and lung is 1136155.9 rubles.Conclusion. We determined the pharmacoeconomic dependence of a chemotherapy on the type of malignant neoplasms of bronchus and lung and the main anticancer drug used. The median of the overall survival rate of patients with malignant neoplasms of bronchus and lung was 42 months. The average cost of drug therapy was 27051.3 rubles per month. The median survival rate without therapy is 3 months. Thus, therapy can extend the patientβs life by an average of 39 months. The cost of a month of a saved life is 29132.2 rubles.Β Π¦Π΅Π»Ρ β ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Ρ ΡΡΠ΅ΡΠΎΠΌ ΡΠΈΠΏΠΎΠ² Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠΎΠ½Ρ
ΠΎΠ² ΠΈ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, ΡΠ°ΡΡΠ΅Ρ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Π°ΠΌΠΈ Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΡΠ»ΡΠΆΠΈΠ»ΠΈ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΠ°ΡΠΈΠΎΠ½Π°ΡΠ° ΠΠΠ£Π ΠΠΠ ΠΈΠΌ. Π.Π. ΠΠ»Π΅ΡΠ½Π΅Π²Π° ΠΠ΅ΠΏΠ°ΡΡΠ°ΠΌΠ΅Π½ΡΠ° Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ Π³. ΠΠΎΡΠΊΠ²Ρ Π·Π° 2019 Π³. Π‘ΡΠΎΠΈΠΌΠΎΡΡΡ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² ΡΠ°ΡΡΡΠΈΡΠ°Π½Π° ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ aptekamos.ru (ΠΈΡΠ½Ρ 2019 Π³.).Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅. ΠΠ° 300 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΏΠ»ΠΎΡΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΠΏΠΎΡΡΠ΅Π±ΡΠ΅ΡΡΡ 3205,5 ΠΊΡΡΡΠΎΠ² Ρ
ΠΈΠΌΠΈΠΎ ΡΠ΅ΡΠ°ΠΏΠΈΠΉ I (1747,5) ΠΈ II (1458) Π»ΠΈΠ½ΠΈΠΉ. ΠΠ° 200 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ Π½Π΅ΠΏΠ»ΠΎΡΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ EGFR ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠΌ ΡΠ°ΠΊΠ΅ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ 1413,1 ΠΊΡΡΡΠΎΠ² Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΈ ΡΠ°ΡΠ³Π΅ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΠ° 70 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ Π½Π΅ΠΏΠ»ΠΎΡΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Ρ ΠΠΠ-ΠΌΡΡΠ°ΡΠΈΠ΅ΠΉ ΠΏΡΠΈΡ
ΠΎΠ΄ΠΈΡΡΡ 450,2 ΠΊΡΡΡΠΎΠ² Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΈ ΡΠ°ΡΠ³Π΅ΡΠ½Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ. ΠΠ° 280 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ Π½Π΅ΠΏΠ»ΠΎΡΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Π±Π΅Π· ΠΌΡΡΠ°ΡΠΈΠΉ ΠΏΠΎΡΡΠ΅Π±ΡΠ΅ΡΡΡ 7515 ΠΊΡΡΡΠΎΠ² Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΠ° 150 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ 1656,8 ΠΊΡΡΡΠΎΠ² Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π½Π° ΠΎΠ±ΡΡΡ Π²ΡΠ±ΠΎΡΠΊΡ ΠΈΠ· 1000 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π±Π΅Π· ΡΡΠ΅ΡΠ° ΡΠΈΠΏΠ° Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠΎΠ½Ρ
ΠΎΠ² ΠΈ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΠΏΠΎΡΡΠ΅Π±ΡΠ΅ΡΡΡ 14239,8 ΠΊΡΡΡΠΎΠ² Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΡΡΠΎΠΈΠΌΠΎΡΡΡ ΡΡΠ΅Π΄Π½Π΅ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΡΡΡΠ° Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π² ΡΠ°ΡΡΠ΅ΡΠ΅ Π½Π° ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° β 67000 ΡΡΠ±. (Ρ ΡΡΠ΅ΡΠΎΠΌ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡΡ
ΠΊΠΎΠ»ΠΎΠ½ΠΈΠ΅ΡΡΠΈΠΌΡΠ»ΠΈΡΡΡΡΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ², ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ²ΠΎΡΠ½ΡΡ
, ΠΈΠ½ΡΡΠ·ΠΈΠΎΠ½Π½ΡΡ
ΡΠ°ΡΡΠ²ΠΎΡΠΎΠ² ΠΈ Ρ.Π΄.); ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΡΡΠ»ΠΎΡΠΈΠ½ΠΈΠ±ΠΎΠΌ (ΠΊΡΡΡ 8 ΠΌΠ΅ΡΡΡΠ΅Π²) β 663408,0 ΡΡΠ±.; ΠΊΡΠΈΠ·ΠΎΡΠΈΠ½ΠΈΠ±ΠΎΠΌ (ΠΊΡΡΡ 11 ΠΌΠ΅ΡΡΡΠ΅Π²) β 2044110,0 ΡΡΠ±. Π‘ΡΠ΅Π΄Π½ΡΡ ΡΡΠΎΠΈΠΌΠΎΡΡΡ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½ΡΠΎΠ·Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° ΡΠΎ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π±ΡΠΎΠ½Ρ
ΠΎΠ² ΠΈ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 1136155,9 ΡΡΠ±.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΠ°ΡΠΌΠ°ΠΊΠΎΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΡΠΈΠΏΠ° Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΡΠΎΠ½Ρ
ΠΎΠ² ΠΈ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΠΎΠ³ΠΎ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠ΅Π΄ΡΡΠ²Π°. ΠΠ΅Π΄ΠΈΠ°Π½Π° ΠΎΠ±ΡΠ΅ΠΉ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠΎ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΠΌΠΈ Π±ΡΠΎΠ½Ρ
ΠΎΠ² ΠΈ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 42 ΠΌΠ΅ΡΡΡΠ°. Π‘ΡΠ΅Π΄Π½ΡΡ ΡΡΠΎΠΈΠΌΠΎΡΡΡ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½ΡΠΎΠ·Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ β 27051,3 ΡΡΠ±./ΠΌΠ΅ΡΡΡ. ΠΠ΅Π΄ΠΈΠ°Π½Π° Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ Π±Π΅Π· ΡΠ΅ΡΠ°ΠΏΠΈΠΈ β 3 ΠΌΠ΅ΡΡΡΠ°. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΠ΅ΡΠ°ΠΏΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΡΠΎΠ΄Π»ΠΈΡΡ ΠΆΠΈΠ·Π½Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° Π² ΡΡΠ΅Π΄Π½Π΅ΠΌ Π½Π° 39 ΠΌΠ΅ΡΡΡΠ΅Π². Π‘ΡΠΎΠΈΠΌΠΎΡΡΡ ΠΌΠ΅ΡΡΡΠ° ΡΠΎΡ
ΡΠ°Π½Π΅Π½Π½ΠΎΠΉ ΠΆΠΈΠ·Π½ΠΈ ΡΠΎΡΡΠ°Π²ΠΈΡ 29132,2 ΡΡΠ±.
Synthesis of High-Purity Silica Nanoparticles by Sol-Gel Method
Colloidal silica (silica sol) nanoparticles were synthesized by ammonia- and hydrochloric acid-catalyzed hydrolysis of tetraethoxysilane with subsequent condensation and polymerization. Silica particles with the size of 12β160 nm were obtained at different temperatures and ratios of the initial reactants and studied by means of TEM, AFM, IR spectroscopy and zeta-potential measurements. The reaction conditions providing the minimum particle size in the final product of the most complete hydrolysis were determined. At pH above 8.5, an increase in the SiO2 content of the sol to 23 wt.% did not change the particle size. At a low (~ 1.8 wt.%) SiO2 content of the sol, a wide variation in pH also did not exert a significant effect on the particle size. Stability of the silica sols synthesized in an alkaline medium was enhanced by the replacement of alcohol with water during evaporation at pH 8.5β9.5. The possibility to produce silica sols with the required characteristics (particle size, pH, stability, purity, and SiO2 content in an aqueous or alcohol medium) makes them applicable in various industries
Direct Catalytic Reduction of SO2 by CH4 over Fe-Mn Catalysts Prepared by Granulation of Ferromanganese Nodules
The chemical, textural, structural and strength properties of ferromanganese nodules and granulated Fe-Mn catalysts containing such nodules were studied. It was found that the granulated catalysts have a developed pore structure, which is close to that of the starting material, and surpass the starting material in strength parameters. The catalysts were tested in desulfurization by methane at a stoichiometric ratio SO2/CH4 = 2. The testing showed that Fe-Mn catalysts with the oxide or sulfide form of active components are active in desulfurization by methane and can selectively reduce SO2 with a conversion above 80%
The dependence of cylindrical resonator natural frequencies on the fluid density
The article examines the dependence of cylindrical resonator natural frequencies (sensitive element) on the density (mass) of different fluids flowing through it. The cylindrical resonators are being widely applied in automatic control systems of technological processes as oscillating transducer density meter. The article presents the experimental results that prove the dependence of natural frequencies and vibration amplitude on the fluid density
Investigation of the Sorption Properties of Ore Materials for the Removal of Sulfur Dioxide from Exhaust Flue Gases of Power Plants
The prospects of using a natural material β ferromanganese nodules (FMN) from the Gulf of Finland β as the SO2 adsorbent are discussed. The starting material was studied as pellets and powder using X-ray fluorescence spectroscopy, XRD, BET, and mechanical strength analysis; dependences of physicochemical parameters of the material on heat treatment at 100-1000 ΒΊC were found. FMN samples were tested in the process of SO2 sorption. The sorptive capacity of FMN samples for SO2 was found to increase with humidity of adsorbents; FMN samples with a humidity above 40% were shown to be promising for the removal of sulfur dioxide from gase
ΠΠ½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡ ΡΡΠΎΠΏΠ°ΡΠΎΠ³Π΅Π½ΠΎΠ² Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΡΡΠΎΠ»ΠΈΡΠΈΠ°Π·ΠΎΠΌ Π½Π° ΡΠΎΠ½Π΅ ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠ΅ΠΉ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΡΠ΅ΡΠ΄ΡΠ°
Objective: to identify the main causative agents of chronic calculous pyelonephritis and determine their antibiotic resistance in patients with nephrolithiasis combined with coronary heart disease (CHD).Material and methods. A retrospective case-control study included 181 patients aged 57 to 82 years old who were treated at the urological center of branch no. 1 of Burdenko Main Military Clinical Hospital in 2014β2019. All patients long-term suffered from urolithiasis complicated by chronic calculus pyelonephritis in combination with CHD. Clinically significant results of bacteriological urine examinations (CFUβ₯103) were analyzed. The midstream urine specimen cultivation was performed sectorally on Endo agar. The minimum suppressive concentration of the test antibacterial preparations for each of the detected microorganisms was determined by dilution on a dense MΓΌllerβHinton agar culture medium (BBL, USA). The results were processed using the ShapiroβWilk, KolmogorovβSmirnov, and Ο2 Pirson criteria. The values of pβ€0,05 were considered as statistically significant.Results. Specimen culturing revealed Escherichia coli β 24.8%, Klebsiella pneumoniae β 18.3%, Pseudomanas aeruginosa β 11%. Staphylococcus spp., and Enterococcus spp. were most important among gram-positive pathogens (total 26.6% of cases). The sensitivity of the detected infectious agents to basic antibacterial drugs turned out to be sharply reduced. It is noteworthy that 65% of P. aeruginosa strains were sensitive to meropenem.Conclusion. In patients with recurrent urolithiasis combined with CHD, the proportion of gram-positive coccas was increased on the background of calculous pyelonephritis with a simultaneous decrease in the proportion of poly-resistant gram-negative infectious agents (nosocomial strains of E. coli and K. pneumoniae).Π¦Π΅Π»Ρ: Π²ΡΡΠ²ΠΈΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠ°Π»ΡΠΊΡΠ»Π΅Π·Π½ΠΎΠ³ΠΎ ΠΏΠΈΠ΅Π»ΠΎΠ½Π΅ΡΡΠΈΡΠ° ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΈΡ
Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΡΡΠΎΠ»ΠΈΡΠΈΠ°Π·ΠΎΠΌ, ΡΠΎΡΠ΅ΡΠ°ΡΡΠΈΠΌΡΡ Ρ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ ΡΠ΅ΡΠ΄ΡΠ° (ΠΠΠ‘).ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎ ΡΠΈΠΏΡ Β«ΡΠ»ΡΡΠ°ΠΉβΠΊΠΎΠ½ΡΡΠΎΠ»ΡΒ», Π² ΠΊΠΎΡΠΎΡΠΎΠ΅ Π²ΠΎΡΠ΅Π» 181 ΠΏΠ°ΡΠΈΠ΅Π½Ρ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 57 Π΄ΠΎ 82 Π»Π΅Ρ, ΠΏΡΠΎΠ»Π΅ΡΠ΅Π½Π½ΡΠΉ Π² ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠ΅Π½ΡΡΠ΅ ΡΠΈΠ»ΠΈΠ°Π»Π° β 1 ΠΠ»Π°Π²Π½ΠΎΠ³ΠΎ Π²ΠΎΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π³ΠΎΡΠΏΠΈΡΠ°Π»Ρ ΠΈΠΌ. Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΠΊΠ° Π.Π. ΠΡΡΠ΄Π΅Π½ΠΊΠΎ Π² 2014β2019 Π³Π³. ΠΡΠ΅ Π±ΠΎΠ»ΡΠ½ΡΠ΅ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΡΡΠ°Π΄Π°Π»ΠΈ ΠΌΠΎΡΠ΅ΠΊΠ°ΠΌΠ΅Π½Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ (ΠΠΠ), ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΠΎΠΉ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΊΠ°Π»ΡΠΊΡΠ»Π΅Π·Π½ΡΠΌ ΠΏΠΈΠ΅Π»ΠΎΠ½Π΅ΡΡΠΈΡΠΎΠΌ, Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΠΠ‘. ΠΠ·ΡΡΠ΅Π½Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π½Π°Π»ΠΈΠ·ΠΎΠ² ΠΌΠΎΡΠΈ (ΠΠΠβ₯103). ΠΠΎΡΠ΅Π² ΡΡΠ΅Π΄Π½Π΅ΠΉ ΠΏΠΎΡΡΠΈΠΈ ΠΌΠΎΡΠΈ Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΠΈ ΡΠ΅ΠΊΡΠΎΡΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π½Π° Π°Π³Π°ΡΠ΅ ΠΠ½Π΄ΠΎ. ΠΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΡΡ ΠΏΠΎΠ΄Π°Π²Π»ΡΡΡΡΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π΄Π»Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΠΈΠ· Π²ΡΡΠ²Π»Π΅Π½Π½ΡΡ
ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ°Π·Π²Π΅Π΄Π΅Π½ΠΈΡ Π½Π° ΠΏΠ»ΠΎΡΠ½ΠΎΠΉ ΠΏΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅Π΄Π΅ Π°Π³Π°ΡΠ° ΠΡΠ»Π»Π΅ΡΠ°βΠ₯ΠΈΠ½ΡΠΎΠ½ (BBL, Π‘Π¨Π). ΠΡΠΈ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ Π¨Π°ΠΏΠΈΡΠΎβΠ£ΠΈΠ»ΠΊΠ°, ΠΠΎΠ»ΠΌΠΎΠ³ΠΎΡΠΎΠ²Π°βΠ‘ΠΌΠΈΡΠ½ΠΎΠ²Π° ΠΈ Ο2 ΠΠΈΡΡΠΎΠ½Π°. Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΠΌΠΈ ΡΡΠΈΡΠ°Π»ΠΈ Π·Π½Π°ΡΠ΅Π½ΠΈΡ Ρβ€0,05.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΈ ΠΏΠΎΡΠ΅Π²Π΅ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π²ΡΡΠ²Π»Π΅Π½Ρ: Escherichia coli β Π² 24,8% ΡΠ»ΡΡΠ°Π΅Π², Klebsiella pneumoniae β Π² 18,3%, Pseudomanas aeruginosa β Π² 11%. Π‘ΡΠ΅Π΄ΠΈ Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅Π΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠ΅Π»ΠΈ Staphylococcus spp. ΠΈ Enterococcus spp. (ΡΡΠΌΠΌΠ°ΡΠ½ΠΎ 26,6% ΡΠ»ΡΡΠ°Π΅Π²). Π§ΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
Π°Π³Π΅Π½ΡΠΎΠ² ΠΊ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌ ΠΎΠΊΠ°Π·Π°Π»Π°ΡΡ ΡΠ΅Π·ΠΊΠΎ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΠΎΠΉ. ΠΠ±ΡΠ°ΡΠ°Π΅Ρ Π½Π° ΡΠ΅Π±Ρ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠΎΡ ΡΠ°ΠΊΡ, ΡΡΠΎ ΠΊ ΠΌΠ΅ΡΠΎΠΏΠ΅Π½Π΅ΠΌΡ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ Π±ΡΠ»ΠΈ 65% ΡΡΠ°ΠΌΠΌΠΎΠ² P. aeruginosa.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΈΡΡΡΡΠ΅ΠΉ ΠΠΠ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΠΠ‘ Π½Π° ΡΠΎΠ½Π΅ ΠΊΠ°Π»ΡΠΊΡΠ»Π΅Π·Π½ΠΎΠ³ΠΎ ΠΏΠΈΠ΅Π»ΠΎΠ½Π΅ΡΡΠΈΡΠ° ΡΠ²Π΅Π»ΠΈΡΠ΅Π½Π° Π΄ΠΎΠ»Ρ Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΊΠΎΠΊΠΊΠΎΠ² Ρ ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π΄ΠΎΠ»ΠΈ ΠΏΠΎΠ»ΠΈΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
Π³ΡΠ°ΠΌΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
Π°Π³Π΅Π½ΡΠΎΠ² (Π½ΠΎΠ·ΠΎΠΊΠΎΠΌΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ°ΠΌΠΌΡ E. coli ΠΈ K. pneumoniae)
Mesoporous Carbon-Based Rhodium Catalysts for Benzene Hydrogenation
Two different carbons, namely CAS-P-500 and CRH-P-500, were prepared from apricot stones and rice husk by H3PO4-activation at 500 ΒΊC and H3PO4/precursor (wt/wt) impregnation ratio of 2:1 followed by water washing and desilication by NaOH solution respectively. Elemental analyses of both samples using X-ray fluorescence spectroscopy and VARIO ELEMENTAR III elemental analyzer detected up to 1% of remained phosphorus and about 88% of carbon. SEM characterization and nitrogen adsorption data revealed that highly mesoporous materials were obtained. According to BJH scheme calculations, N2 BET-surface area and pore volume for CAS-P-500 reached the values of 2030 m2/g and 1.64 cm3/g, while for CRH-P-500: 1690 m2/g and 1.95 cm3/g respectively. Activated carbons CAS-P-500 and CRH-P-500 were used as catalyst supports for the conversion of small amounts of benzene into cyclohexane to obtain cleaner gasoline. According to Euro-3 standards, gasoline should contain less than 1% of benzene, since the incomplete combustion of gasoline, which contains benzene, leads to formation of benzopyrene- a powerful carcinogen in exhaust gases. The activity of rhodium catalysts based on the CAS-P-500 and CRH-P-500 allow complete conversion of benzene into cyclohexane at 40 atm and 80oC temperature and is comparable to those of based on conventional carbons: βSibunitβ, etc
A New and Fast Technique to Generate Offspring after Germ Cells Transplantation in Adult Fish: The Nile Tilapia (Oreochromis niloticus) Model
Background: Germ cell transplantation results in fertile recipients and is the only available approach to functionally investigate the spermatogonial stem cell biology in mammals and probably in other vertebrates. In the current study, we describe a novel non-surgical methodology for efficient spermatogonial transplantation into the testes of adult tilapia (O. niloticus), in which endogenous spermatogenesis had been depleted with the cytostatic drug busulfan. Methodology/Principal Findings: Using two different tilapia strains, the production of fertile spermatozoa with donor characteristics was demonstrated in adult recipient, which also sired progeny with the donor genotype. Also, after cryopreservation tilapia spermatogonial cells were able to differentiate to spermatozoa in the testes of recipient fishes. These findings indicate that injecting germ cells directly into adult testis facilitates and enable fast generation of donor spermatogenesis and offspring compared to previously described methods. Conclusion: Therefore, a new suitable methodology for biotechnological investigations in aquaculture was established, with a high potential to improve the production of commercially valuable fish, generate transgenic animals and preserv
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