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Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.
Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution of the PKR kinase domain in vertebrates, coupled with positive selection of specific sites. Substitution of positively selected residues in human PKR with residues found in related species altered sensitivity to PKR inhibitors from different poxviruses. Species-specific differences in sensitivity to poxviral pseudosubstrate inhibitors were identified between human and mouse PKR, and these differences were traced to positively selected residues near the eIF2alpha binding site. Our findings indicate how an antiviral protein evolved to evade viral inhibition while maintaining its primary function. Moreover, the identified species-specific differences in the susceptibility to viral inhibitors have important implications for studying human infections in nonhuman model systems
Non-monotonic temperature dependent transport in graphene grown by Chemical Vapor Deposition
Temperature-dependent resistivity of graphene grown by chemical vapor
deposition (CVD) is investigated. We observe in low mobility CVD graphene
device a strong insulating behavior at low temperatures and a metallic behavior
at high temperatures manifesting a non-monotonic in the temperature dependent
resistivity.This feature is strongly affected by carrier density modulation. To
understand this anomalous temperature dependence, we introduce thermal
activation of charge carriers in electron-hole puddles induced by randomly
distributed charged impurities. Observed temperature evolution of resistivity
is then understood from the competition among thermal activation of charge
carriers, temperature-dependent screening and phonon scattering effects. Our
results imply that the transport property of transferred CVD-grown graphene is
strongly influenced by the details of the environmentComment: 7 pages, 3 figure
Tuning electronic structures via epitaxial strain in Sr2IrO4 thin films
We have synthesized epitaxial Sr2IrO4 thin-films on various substrates and
studied their electronic structures as a function of lattice-strains. Under
tensile (compressive) strains, increased (decreased) Ir-O-Ir bond-angles are
expected to result in increased (decreased) electronic bandwidths. However, we
have observed that the two optical absorption peaks near 0.5 eV and 1.0 eV are
shifted to higher (lower) energies under tensile (compressive) strains,
indicating that the electronic-correlation energy is also affected by in-plane
lattice-strains. The effective tuning of electronic structures under
lattice-modification provides an important insight into the physics driven by
the coexisting strong spin-orbit coupling and electronic correlation.Comment: 9 pages, 5 figures, 1 tabl
Asynchronous Graph Pattern Matching on Multiprocessor Systems
Pattern matching on large graphs is the foundation for a variety of
application domains. Strict latency requirements and continuously increasing
graph sizes demand the usage of highly parallel in-memory graph processing
engines that need to consider non-uniform memory access (NUMA) and concurrency
issues to scale up on modern multiprocessor systems. To tackle these aspects,
graph partitioning becomes increasingly important. Hence, we present a
technique to process graph pattern matching on NUMA systems in this paper. As a
scalable pattern matching processing infrastructure, we leverage a
data-oriented architecture that preserves data locality and minimizes
concurrency-related bottlenecks on NUMA systems. We show in detail, how graph
pattern matching can be asynchronously processed on a multiprocessor system.Comment: 14 Pages, Extended version for ADBIS 201
Charge Fluctuations in Geometrically Frustrated Charge Ordering System
Effects of geometrical frustration in low-dimensional charge ordering systems
are theoretically studied, mainly focusing on dynamical properties. We treat
extended Hubbard models at quarter-filling, where the frustration arises from
competing charge ordered patterns favored by different intersite Coulomb
interactions, which are effective models for various charge transfer-type
molecular conductors and transition metal oxides. Two different lattice
structures are considered: (a) one-dimensional chain with intersite Coulomb
interaction of nearest neighbor V_1 and that of next-nearest neighbor V_2, and
(b) two-dimensional square lattice with V_1 along the squares and V_2 along one
of the diagonals. From previous studies, charge ordered insulating states are
known to be unstable in the frustrated region, i.e., V_1 \simeq 2V_2 for case
(a) and V_1 \simeq V_2 for case (b), resulting in a robust metallic phase even
when the interaction strenghs are strong. By applying the Lanczos exact
diagonalization to finite-size clusters, we have found that fluctuations of
different charge order patterns exist in the frustration-induced metallic
phase, showing up as characteristic low energy modes in dynamical correlation
functions. Comparison of such features between the two models are discussed,
whose difference will be ascribed to the dimensionality effect. We also point
out incommensurate correlation in the charge sector due to the frustration,
found in one-dimensional clusters.Comment: 8 pages, 9 figure
Effects of pressure on the ferromagnetic state of the CDW compound SmNiC2
We report the pressure response of charge-density-wave (CDW) and
ferromagnetic (FM) phases of the rare-earth intermetallic SmNiC2 up to 5.5 GPa.
The CDW transition temperature (T_{CDW}), which is reflected as a sharp
inflection in the electrical resistivity, is almost independent of pressure up
to 2.18 GPa but is strongly enhanced at higher pressures, increasing from 155.7
K at 2.2 GPa to 279.3 K at 5.5 GPa. Commensurate with the sharp increase in
T_{CDW}, the first-order FM phase transition, which decreases with applied
pressure, bifurcates into the upper (T_{M1}) and lower (T_c) phase transitions
and the lower transition changes its nature to second order above 2.18 GPa.
Enhancement both in the residual resistivity and the Fermi-liquid T^2
coefficient A near 3.8 GPa suggests abundant magnetic quantum fluctuations that
arise from the possible presence of a FM quantum critical point.Comment: 5 pages, 5 figure
Singlet superfield extension of the minimal supersymmetric standard model with Peccei-Quinn symmetry and a light pseudoscalar Higgs boson at the LHC
Motivated by the mu-problem and the axion solution to the strong CP-problem,
we extend the MSSM with one more chiral singlet field . The underlying
PQ-symmetry allows only one more term in the superpotential. The
spectrum of the Higgs system includes a light pseudoscalar (in addition
to the standard CP-even Higgs boson), predominantly decaying to two photons:
. Both Higgs bosons might be in the range accessible to
current LHC experiments.Comment: 5 pages with 3 figure
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