The pathology of Lates calcarifer herpesviral disease—Disseminated intravascular coagulation explains mortality spikes

Lates calcarifer herpesvirus (LCHV) causes an emerging serious disease in aquaculture. Sudden drops in feed rates and mortality spikes exceeding 40%–50% often accompany LCHV infections in juvenile L. calcarifer, soon after transfer into sea cages. Affected fish have patchy white skin and fins, corneal opacity and frequently hang in surface water column like ‘ghost’ or ‘zombie’ fish. Fish have pale gills, fluid-filled intestines with yellowish casts, lipid depleted liver, enlarged spleen and kidney and reddened brain. Epithelial hyperplasia, apoptosis, marginated nuclear chromatin, amphophilic intranuclear inclusion bodies and the occasional multinucleated cells are observed in gills, skin, intestines, liver and kidney. These are often accompanied by lymphocytic-monocytic infiltration and extensive necrosis in gills, skin, kidney and intestines. Martius scarlet blue stains indicate presence of fibrin in vasculature in brain, gills, intestines, kidney and liver, or disseminated intravascular coagulation (DIC). DIC has been reported in human herpesviral infections. Multifocal lifting of intestinal epithelium with proteinaceous exudate and necrosis of several adjacent villi often progress to involve entire gut sections. Atrophied livers with accentuated lobules may progress to marked loss of hepatic acini. Multifocal dilated attenuated renal tubules are often accompanied by casts and marked protein loosing renopathy. This study on LCHV demonstrates that it can cause significant pathology and mortality

Analysis of the temperature influence on Langmuir probe measurements on the basis of gyrofluid simulations

The influence of the temperature and its fluctuations on the ion saturation current and the floating potential, which are typical quantities measured by Langmuir probes in the turbulent edge region of fusion plasmas, is analysed by global nonlinear gyrofluid simulations for two exemplary parameter regimes. The numerical simulation facilitates a direct access to densities, temperatures and the plasma potential at different radial positions around the separatrix. This allows a comparison between raw data and the calculated ion saturation current and floating potential within the simulation. Calculations of the fluctuation-induced radial particle flux and its statistical properties reveal significant differences to the actual values at all radial positions of the simulation domain, if the floating potential and the temperature averaged density inferred from the ion saturation current is used.Comment: Submitted to Plasma Physics and Controlled Fusio

Concentric double hollow grid cathode discharges

A new cathode system, consisting of two concentric spherical hollow grids with two aligned orifices, is investigated by space-resolved Langmuir probe measurements and non-linear dynamics analysis. Negative biases of this spherical hollow grids arrangement lead to the formation of two complex space charge structures in the regions of the orifices. The overall dynamics of the current-voltage characteristic (I–V characteristic) of each discharge is characterized by strong oscillatory behaviour with various waveforms correlated with jumps in the static I–V characteristics. Space-resolved measurements through the two aligned orifices of the two grids show a peak increase of the electron temperature and particle density in the regions of the two space-charge structures. The effects of the biases and Ar pressure on the overall spatial distribution of all plasma parameters are investigated. Two important working points of the concentric double hollow grid cathode discharges are revealed which could make this configuration suitable as an electron source

Formal framework for reasoning about the precision of dynamic analysis

Dynamic program analysis is extremely successful both in code debugging and in malicious code attacks. Fuzzing, concolic, and monkey testing are instances of the more general problem of analysing programs by dynamically executing their code with selected inputs. While static program analysis has a beautiful and well established theoretical foundation in abstract interpretation, dynamic analysis still lacks such a foundation. In this paper, we introduce a formal model for understanding the notion of precision in dynamic program analysis. It is known that in sound-by-construction static program analysis the precision amounts to completeness. In dynamic analysis, which is inherently unsound, precision boils down to a notion of coverage of execution traces with respect to what the observer (attacker or debugger) can effectively observe about the computation. We introduce a topological characterisation of the notion of coverage relatively to a given (fixed) observation for dynamic program analysis and we show how this coverage can be changed by semantic preserving code transformations. Once again, as well as in the case of static program analysis and abstract interpretation, also for dynamic analysis we can morph the precision of the analysis by transforming the code. In this context, we validate our model on well established code obfuscation and watermarking techniques. We confirm the efficiency of existing methods for preventing control-flow-graph extraction and data exploit by dynamic analysis, including a validation of the potency of fully homomorphic data encodings in code obfuscation

Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS)) : Part B

In 2014 the International Endohernia Society (IEHS) published the first international "Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias". Guidelines reflect the currently best available evidence in diagnostics and therapy and give recommendations to help surgeons to standardize their techniques and to improve their results. However, science is a dynamic field which is continuously developing. Therefore, guidelines require regular updates to keep pace with the evolving literature. Methods For the development of the original guidelines all relevant literature published up to year 2012 was analyzed using the ranking of the Oxford Centre for Evidence-Based-Medicine. For the present update all of the previous authors were asked to evaluate the literature published during the recent years from 2012 to 2017 and revise their statements and recommendations given in the initial guidelines accordingly. In two Consensus Conferences (October 2017 Beijing, March 2018 Cologne) the updates were presented, discussed, and confirmed. To avoid redundancy, only new statements or recommendations are included in this paper. Therefore, for full understanding both of the guidelines, the original and the current, must be read. In addition, the new developments in repair of abdominal wall hernias like surgical techniques within the abdominal wall, release operations (transversus muscle release, component separation), Botox application, and robot-assisted repair methods were included. Results Due to an increase of the number of patients and further development of surgical techniques, repair of primary and secondary abdominal wall hernias attracts increasing interests of many surgeons. Whereas up to three decades ago hernia-related publications did not exceed 20 per year, currently this number is about 10-fold higher. Recent years are characterized by the advent of new techniques-minimal invasive techniques using robotics and laparoscopy, totally extraperitoneal repairs, novel myofascial release techniques for optimal closure of large defects, and Botox for relaxing the abdominal wall. Furthermore, a concomitant rectus diastasis was recognized as a significant risk factor for recurrence. Despite still insufficient evidence with respect to these new techniques it seemed to us necessary to include them in the update to stimulate surgeons to do research in these fields. Conclusion Guidelines are recommendations based on best available evidence intended to help the surgeon to improve the quality of his daily work. However, science is a continuously evolving process, and as such guidelines should be updated about every 3 years. For a comprehensive reference, however, it is suggested to read both the initially guidelines published in 2014 together with the update. Moreover, the presented update includes also techniques which were not known 3 years before