Changes in Energy Expenditure with Ingestion of High Protein, High Fat versus High Protein, Low Fat Meals among Underweight, Normal Weight, and Overweight Females.

Background: Metabolic rate is known to rise above basal levels after eating, especially following protein consumption. Yet, this postprandial rise in metabolism appears to vary among individuals. This study examined changes in energy expenditure in response to ingestion of a high protein, high fat (HPHF) meal versus an isocaloric high protein, low fat (HPLF) meal in underweight, normal weight, or overweight females (n = 21) aged 19–28 years. Methods: Energy expenditure, measured using indirect calorimetry, was assessed before and every 30 minutes for 3.5 hours following consumption of the meals on two separate occasions. Height and weight were measured using standard techniques. Body composition was measured using bioelectrical impedance analysis. Results: Significant positive correlations were found between body mass index (BMI) and baseline metabolic rate (MR) (r = 0.539; p = 0.017), between body weight and baseline MR (r = 0.567; p = 0.011), between BMI and average total change in MR (r = 0.591; p = 0.008), and between body weight and average total change in MR (r = 0.464; p = 0.045). Metabolic rate (kcal/min) was significantly higher in the overweight group than the normal weight group, which was significantly higher than the underweight group across all times and treatments. However, when metabolic rate was expressed per kg fat free mass (ffm), no significant difference was found in postprandial energy expenditure between the overweight and normal groups. Changes in MR (kcal/min and kcal/min/kg ffm) from the baseline rate did not significantly differ in the underweight (n = 3) or in the overweight subjects (n = 5) following consumption of either meal at any time. Changes in MR (kcal/min and kcal/min/kg ffm) from baseline were significantly higher in normal weight subjects (n = 11) across all times following consumption of the HPHF meal versus the HPLF meal. Conclusion: There is no diet-induced thermogenic advantage between the HPHF and HPLF meals in overweight and underweight subjects. In contrast, in normal weight subjects, ingestion of a HPHF meal significantly increases MR (69.3 kcal/3.5 hr) versus consumption of a HPLF meal and provides a short-term metabolic advantage

Integrated Nutrient Management for Natural Grasslands of Mid-Hills of Himalayas

Livestock rearing is an important pursuit in mountain farming in India and plays a crucial role throughout the country. The preponderance of marginal and small landholdings (about 82%) in hilly regions does not allow the farmers to allocate even a small part of their land exclusively for forage production. In Himachal Pradesh state of India about 1.16 m ha (20% of the total area) is under permanent pastures and other grazing lands and none of the natural grasslands are fertilised in any form. Existing grasslands have deteriorated to such an extent that their carrying capacity is only 1.05 ACU (Adult Cattle Unit, with an average body weight of 350 kg)/ha (Vashist et al., 2000). Biofertiliser-based technologies could be appropriate and cost effective approaches that are easy to adopt and eco-friendly. Response may arise from increased populations of phosphate solubilisers in the rhizosphere in P- deficient soils resulting in mobilisation of insoluble phosphorus (Raghu & Mac Rac, 1967). The study was undertaken with the main objectives of assessing the effects of biofertilisers on productivity and quality of natural grassland and the level of N and P substitution by biofertilisers

A Longitudinal Study of the Temporal Relation Between Problem Gambling and Mental and Substance Use Disorders Among Young Adults

Objective: Relatively little is known about the temporal relation between at-risk gambling or problem gambling (PG) and mental and substance use disorders (SUDs) in young adulthood. Our study aimed to examine whether past-year, at-risk, or PG is associated with incident mental disorders and SUDs (that is, depression, generalized anxiety disorder, obsessive–compulsive disorder [OCD], or alcohol dependence) and illegal drug use, and whether past-year mental disorders and SUDs and illegal drug use is associated with incident at-risk or PG. Method: Data for this longitudinal study were drawn from the Manitoba Longitudinal Study of Young Adults (MLSYA). Respondents aged 18 to 20 years in 2007 were followed prospectively for 5 years. Results: In cross-sectional analyses, at-risk or PG was associated with increased odds of depression, OCD, alcohol dependence, and illegal drug use. In longitudinal analysis at-risk or PG at cycle 1 was associated with incident major depressive disorder, alcohol dependence, and illegal drug use in the follow-up period. Only illegal drug use at cycle 1 was associated with incident at-risk or PG during follow-up. Conclusions: At-risk or PG was associated with more new onset mental disorders and SUDs (depression, alcohol dependence, and illegal drug use), compared with the reverse (illegal drug use was the only association with new onset at-risk or PG). Preventing at-risk or PG from developing early in adulthood may correspond with decreases in new onset mental disorders and SUDs later in adulthood

SYNTHESIS, CHARACTERIZATION AND BIOCIDAL ACTIVITY OF NOVEL HALOGENATED -4-[(SUBSTITUTED-BENZOTHIAZOL-2-YL) HYDRAZONO]-2- (SUBSTITUTED-PHENYL)-5-METHYL /ETHOXY -2,4-DIHYDRO-PYRAZOL-3-ONE DERIVATIVES

ABSTRACT Some new 4-[(substituted-benzothiazol-2-yl)hydrazono]-2-(substituted-phenyl)-5-methyl/ethoxy-2,4-dihydro-pyrazol-3-one(4) have been synthesized by reacting substituted 2-amino benzothiazol (1) with acetoacetic ester and malonic ester (2). 2-[(substituted-benzothiazol-2-yl)hydrazono]-3-oxo-butyric acid ethyl ester and 2-[(substituted-benzothiazol-2-yl)hydrazono]-malonic acid diethyl ester (3) react with different hydrazines to give the title compounds(4). These compounds are evaluated for their antifungal and insecticidal activity

Sustaining or declining physical activity: Reports from an ethnically diverse sample of older adults

Over 80% of adults in the US fail to meet the ≥150 min weekly physical activity guideline; 40% age ≥ 75 are entirely inactive. The study purpose was to understand the reasons why community-dwelling older adults (age ≥ 60) from diverse backgrounds increase, sustain, or decline in their physical activity levels over time. Sixty-two older adults were interviewed. Two-thirds of the African Americans, 57% of the Afro-Caribbeans, and 50% of the European Americans reported being less active than 2–3 years ago. Reasons for activity decline included health issues (e.g., pain, shortness of breath), lack of time, interest, or motivation. Reasons for sustaining or increasing activity levels included meeting personal goals, having a purpose for remaining active, or feeling better when active (e.g., it is important to keep moving, good for the joints, going on a cruise). Themes identified were pride in maintaining activity, goal-driven activity, pushing oneself to get past pain or fatigue, and some confusion between social and physical activity in participant reports. The results indicate widespread acceptance that activity is beneficial, but that knowledge alone was insufficient to maintain activity levels over time unless individuals had a goal or purpose (“means to an end”) and could overcome their physical and psychological barriers to physical activity

Juvenile root traits show limited correlation with grain yield, yield components and grain mineral composition traits in Indian wheat under hostile soils

Correlations between juvenile wheat root traits, and grain yield and yield component traits under optimal field conditions have previously been reported in some conditions. The aim of this study was to test the hypothesis that juvenile wheat root traits correlate with yield, yield components and grain mineral composition traits under a range of soil environments in India. A diverse panel of 36 Indian wheat genotypes were grown for ten days in ‘pouch and wick’ high-throughput phenotyping (HTP) system (20 replicates). Correlations between juvenile root architecture traits, including primary and lateral root length, and grain yield, yield components and grain mineral composition traits were determined, using field data from previously published experiments at six sites in India. Only a limited number of juvenile root traits correlated with grain yield (GYD), yield components, and grain mineral composition traits. A narrow root angle, potentially representing a ‘steep’ phenotype, was associated with increased GYD and harvest index (HI) averaged across sites and years. Length related root traits were not correlated with GYD or HI at most sites, however, the total length of lateral roots and lateral root number correlated with GYD at a sodic site of pH 9.5. The total length of lateral roots (TLLR) correlated with grain zinc (Zn) concentration at one site. A wider root angle, representing a shallow root system, correlated with grain iron (Fe) concentration at most sites. The total length of all roots (TLAR) and total length of primary roots (TLPR) correlated with grain S concentration at most sites. Narrow root angle in juvenile plants could be a useful proxy trait for screening germplasm for improved grain yield. Lateral root and shallow root traits could potentially be used to improve grain mineral concentrations. The use of juvenile root traits should be explored further in wheat breeding for diverse environments

Validity of energy social research during and after COVID-19: challenges, considerations, and responses

Measures to control the spread of coronavirus disease 2019 (COVID-19) are having unprecedented impacts on people’s lives around the world. In this paper, we argue that those conducting social research in the energy domain should give special consideration to the internal and external validity of their work conducted during this pandemic period. We set out a number of principles that researchers can consider to give themselves and research users greater confidence that findings and recommendations will still be applicable in years to come. Largely grounded in existing good practice guidance, our recommendations include collecting and reporting additional supporting contextual data, reviewing aspects of research design for vulnerability to validity challenges, and building in longitudinal elements where feasible. We suggest that these approaches also bring a number of opportunities to generate new insights. However, we caution that a more systemic challenge to validity of knowledge produced during this period may result from changes in the kinds of social research that it is practicable to pursue

Hypoxia-induced shift in the phenotype of proteasome from 26S toward immunoproteasome triggers loss of immunoprivilege of mesenchymal stem cells

Allogeneic mesenchymal stem cells (MSCs) are immunoprivileged and are being investigated in phase I and phase II clinical trials to treat different degenerative and autoimmune diseases. In spite of encouraging outcome of initial trials, the long-term poor survival of transplanted cells in the host tissue has declined the overall enthusiasm. Recent analyses of allogeneic MSCs based studies confirm that after transplantation in the hypoxic or ischemic microenvironment of diseased tissues, MSCs become immunogenic and are rejected by recipient immune system. The immunoprivilege of MSCs is preserved by absence or negligible expression of cell surface antigen, human leukocyte antigen (HLA)-DRα. We found that in normoxic MSCs, 26S proteasome degrades HLA-DRα and maintains immunoprivilege of MSCs. The exposure to hypoxia leads to inactivation of 26S proteasome and formation of immunoproteasome in MSCs, which is associated with upregulation and activation of HLA-DRα, and as a result, MSCs become immunogenic. Furthermore, inhibition of immunoproteasome formation in hypoxic MSCs preserves the immunoprivilege. Therefore, hypoxia-induced shift in the phenotype of proteasome from 26S toward immunoproteasome triggers loss of immunoprivilege of allogeneic MSCs. The outcome of the current study may provide molecular targets to plan interventions to preserve immunoprivilege of allogeneic MSCs in the hypoxic or ischemic environment

Slope deviatory alignment, stream network and lineament orientation of the Sabarmati river system- neotectonic activity in the Mid -to Late Quaternary

The Gujarat alluvial plain located in the semi-arid zone is bounded by the arid Thar region in the north and the coastal/estuarine zone fringing the Arabian Sea in the south. It has been built by the rivers originating in the Aravalli Hills in the northeast. The drainages, with an average length of about 300 km, generally follow the NE-SW regional slope. However, the Sabannati River shows a flow deviating from the regional slope and follows a N-S to NNE-SSW trend in the alluvial area. The slope-deviatory trend of the Sabarmati has been investigated with regard to Late Quaternary neotectonics, fluvial-aeolian interaction and sea-level change. Lineament analysis indicates an E-W to WNW-ESE trajectory of maximum principal stress, and that drainage is primarily controlled by geodynamic processes. This is obvious from the correspondence in stress trajectories obtained from the lineament and drainage orientations, respectively. Sub-surface data indicate pre-Neogene faulting in the basin. It is inferred that these faults have been reactivated in the Mid- to Late Quaternary times. The slope-deviatory drainage of the Sabarmati River is, to a large extent, the result of fluvial adjustment to neotectonic reactivation in the region