The Effects of Vitamins on Micropropagation of Desiree and Mozart Potatoes (Solanum Tuberosum L.)

An attempt was done to achieve a micropropagation protocol by determining the most optimal types and concentrations of vitamins including thiamine (B1), nicotinic acid (B3), pyridoxine (B6) and folic acid to induce shoot formation and rooting in vitro, as replacement vitamins in the culture medium. The four vitamins were included in the medium at two concentrations and the control treatment without vitamins. The highest number of shoots per explant (2.50 shoots/ explant) was achieved from the addition of 0.3 mgl-1thiamin to Desiree cultivar grown on MS medium. Whereas, the highest mean length of shoots was recorded in the case of adding nicotinic acid at 3.0 mgl-1 to Mozart cultivar grown on MS medium. The highest number of leaves 10.50 leaves/ explant) was obtained from Mozart cultivar grown on a medium enriched with 0.6 mgl-1 pyridoxine. The highest number of roots (7.00 roots/ explant) was achieved from the control treatment from Desiree potato cultivar. The longest roots (12.50 cm) were produced by Desiree potato cultivar grown on MS medium supplemented with 0.5 mgl-1 thiamin. Mozart potato cultivar performed better than Desiree cultivar in concern to mean length of shoots, number of leaves, number of roots and mean length of roots. No significant differences were found between the both cultivars in concern to the number of shoots and roots

Improved linear response for stochastically driven systems

The recently developed short-time linear response algorithm, which predicts the average response of a nonlinear chaotic system with forcing and dissipation to small external perturbation, generally yields high precision of the response prediction, although suffers from numerical instability for long response times due to positive Lyapunov exponents. However, in the case of stochastically driven dynamics, one typically resorts to the classical fluctuation-dissipation formula, which has the drawback of explicitly requiring the probability density of the statistical state together with its derivative for computation, which might not be available with sufficient precision in the case of complex dynamics (usually a Gaussian approximation is used). Here we adapt the short-time linear response formula for stochastically driven dynamics, and observe that, for short and moderate response times before numerical instability develops, it is generally superior to the classical formula with Gaussian approximation for both the additive and multiplicative stochastic forcing. Additionally, a suitable blending with classical formula for longer response times eliminates numerical instability and provides an improved response prediction even for long response times

Current and emerging osteoporosis pharmacotherapy for women: state of the art therapies for preventing bone loss.

INTRODUCTION: Pharmacological options to address the imbalance between bone resorption and accrual in osteoporosis include anti-resorptive and osteoanabolic agents. Unique biologic pathways such as the Wnt/β-catenin pathway have been targeted in the quest for new emerging therapeutic strategies. Areas covered: This review provides an overview of existing pharmacotherapy for osteoporosis in women and explore state-of-the-art and emerging therapies to prevent bone loss, with an emphasis on the mechanism of action, indications and side effects. Expert opinion: Bisphosphonates appear to be a reliable and cost-effective option, whereas denosumab has introduced a simpler dosing regimen and may achieve a linear increase in bone mineral density (BMD) with no plateau being observed, along with continuous anti-fracture efficacy. Abaloparatide, a parathyroid-hormone-related peptide (PTHrP)-analogue, approved by the FDA in April 2017, constitutes the first new anabolic osteoporosis drug in the US for nearly 15 years and has also proven its anti-fracture efficacy. Romosozumab, a sclerostin inhibitor, which induces bone formation and suppresses bone resorption, has also been developed and shown a significant reduction in fracture incidence; however, concerns have arisen with regard to increased cardiovascular risk

Age and growth of the dusky grouper Epinephelus marginatus (Lowe 1834) in an exploited population of the western Mediterranean Sea

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