21 research outputs found
Pyridazines. LXXVIII. Use of N,N-Dimethylaminomethylene Derivatives of Some Amino and Hydrazino Heterocycles in Organic Synthesis
The formation of N,N-dimethylaminomethylenehydrazino derivatives
of pyridazine and azolopyridaz~nes is described and th.e
synthetic utility of these compounds is explored. An unusual transformation
could be observed with a aminomethyleinehydrazino
derivative where upon .nitrosation the side chain is trainsformed
into an azido group. From the corresponding N,N-dimethylaminomethyleneamino
derivatives two new tricyclic azolotriazolopyridazmes
could be prepared
Pyridazines. LXXVIII. Use of N,N-Dimethylaminomethylene Derivatives of Some Amino and Hydrazino Heterocycles in Organic Synthesis
The formation of N,N-dimethylaminomethylenehydrazino derivatives
of pyridazine and azolopyridaz~nes is described and th.e
synthetic utility of these compounds is explored. An unusual transformation
could be observed with a aminomethyleinehydrazino
derivative where upon .nitrosation the side chain is trainsformed
into an azido group. From the corresponding N,N-dimethylaminomethyleneamino
derivatives two new tricyclic azolotriazolopyridazmes
could be prepared
Chancen und Herausforderungen der Digitalisierung am Beispiel des TeleDerm-Projekts - Ergebnispräsentation und Selbsterfahrung
Pyran-2-ones as synthons for pyridazine-3-carboxylic derivatives. Oxidation of nitrogen-rich compounds
Byla studována reakce 3-amino-6-(pyridin-2-yl)-2H-pyran-2-onu s N2H4.H2O s deriváty pyridazine. Ke zjištění reakčního mechanismu byl úspěšně izolován intermediárně vznikající ?,?-dihydrazonohydrazid. Popsány jsou také oxidace výše uvedených sloučenin a jiných derivátů pyridazinu obsahujících karbohydrazidovou skupinu dusičnanem ceričito-amonným (CAN), trihydrátem dusičnanu thallitého (TTN) nebo hydrátem octanu měďnatéhoThe reaction of 3-amino-6-(pyridin-2-yl)-2H-pyran-2-one with N2H4.H2O towards pyridazine derivs. was investigated. To elucidate the reaction pathway, an intermediary-formed ?,?-dihydrazono hydrazide was successfully isolated. Oxidns. of the above compds. as well as of other pyridazine derivs. contg. a carbohydrazido group, using cerium(IV) ammonium nitrate (CAN), thallium(III) nitrate trihydrate (TTN), or copper(II) acetate hydrate (CuDA), are also presented
Implementierung teledermatologischer Konsile in Hausarztpraxen: Erste Ergebnisse aus dem Innovationsfondsprojekt TELEDerm
Entwicklung eines Research-Ready-Konzeptes für die Initiative Deutscher Forschungspraxennetze - DESAM-ForNet
Biological evaluation of diazene derivatives as anti-tubercular compounds.
<p>Despite efforts made in chemotherapeutic research in the past and present, Mycobacterium tuberculosis (M.tb), the etiological agent of tuberculosis, still causes more than a million deadly casualties each year, second only to HIV. The rapid generation and spread of drug resistant strains, a problem exacerbated by co-infection with HIV demands further efforts in the investigation of novel classes of anti-tubercular compounds. A library of eight substituted diazenecarboxamides, three carbamoyldiazenecarboxylates and four diazene-1,2-dicarboxamides was synthesized in a straightforward manner followed by a biological evaluation of the compounds. We observed minimal inhibitory concentrations below 10 μg/mL against the H37Rv lab strain of M.tb. Three compounds that showed a potency of 90% growth inhibition of M.tb at a concentration lower than 10 μg/mL were further evaluated and showed potency against other clinically relevant mycobacterial species such as Mycobacterium bovis, Mycobacterium avium and Mycobacterium ulcerans. The selected compounds were examined for acute cell toxicity on a murine macrophage like monocyte cell line J774 A.1 in which the cell viability was reduced by 50% at concentrations ranging from 7.4 μg/mL to 20.7 μg/mL. Neither of the three compounds showed signs of genotoxicity by VITOTOX or by Comet assay. The study was complemented by demonstration of the inhibition of intracellular replication of M.tb H37Rv inside J774 A.1 cells at 2 μg/mL concentration and the susceptibility of a MDR LAM-1 strain at concentrations between 5 and 1 μg/mL of the most active compound.</p></p
Synthesis and X-ray-analysis of Spiro Compounds From Twofold [2+2] Cycloaddition of Ynamines To Carbon Suboxide
The first 1,1'-spirocyclobutenones 5 are obtained from ynamines and carbon suboxide via a double cycloaddition. The X-ray analysis data are discussed in detail