Boundary layer studies in an arc-heated tunnel Final report, May 1, 1965 - Oct. 31, 1967

Experimental and theoretical analyses of high speed laminar boundary layer in nozzle of arc heated wind tunne

Experimental analyses of trailing edge flows

An experimental study of several of the trailing edge and wake turbulence properties for a NACA 64A010 airfoil section was completed. The experiment was conducted at the Ohio State University Aeronautical and Astronautical Research Laboratory in the 6 inch X 22 inch transonic wind tunnel facility. The data were obtained at a free stream Mach number of 0.80 and a flow Reynolds number (based on chord length) of 5 million. The principle diagnostic tool was a dual-component laser Doppler velocimeter. The experimental data included surface static pressures, chordwise and vertical mean velocities, RMS turbulence intensities, local flow angles, and a determination of turbulence kinetic energy in the wake. Two angles of attack (0 and 2 degrees) were investigated. At these incidence angles, four flow field surveys were obtained ranging in position from the surface of the airfoil, between the transonic shock and the trailing edge, to the far-wake. At both angles of attack, the turbulence intensities and turbulence kinetic energy were observed to decay in the streamwise direction. In the far wake, for the non-lifting case, the turbulence intensities were nearly isotropic. For the two degree case, the horizontal component of the turbulence intensity was observed to be substantially higher than the vertical component

Cognitive support for older people from multimedia options

If older users of multimedia displays could select among presentation options, would they choose display combinations that supported their performance? After three short touch-screen tasks which measured the perceptual and cognitive abilities of 50 older adults, they answered questions about a route on an online map that could be accompanied by written and/or spoken text. Half the participants saw animated routes; and they were less accurate answering questions than those who saw static routes but this did not affect people’s multimedia choices which, although diverse, were systematic. Spoken text was more often selected by people who had lower scores on the spatial working memory task, than by the older adults with higher scores. This suggests that older people with cognitive limitations recognise ways in which multimedia information can be supportive

Protocol for the effective feedback to improve primary care prescribing safety (EFIPPS) study : a cluster randomised controlled trial using ePrescribing data

High-risk prescribing in primary care is common and causes considerable harm. Feedback interventions to improve care are attractive because they are relatively cheap to widely implement. There is good evidence that feedback has small to moderate effects, but the most recent Cochrane review called for more high-quality, large trials that explicitly test different forms of feedback. The study is a three-arm cluster-randomised trial with general practices being randomised and outcomes measured at patient level. 262 practices in three Scottish Health Board areas have been randomised (94% of all possible practices). The two active arms receive different forms of prescribing safety data feedback, with rates of high-risk prescribing compared with a ‘usual care’ arm. Sample size estimation used baseline data from participating practices. With 85 practices randomised to each arm, then there is 93% power to detect a 25% difference in the percentage of high-risk prescribing (from 6.1% to 4.5%) between the usual care arm and each intervention arm. The primary outcome is a composite of six high-risk prescribing measures (antipsychotic prescribing to people aged ≥75 years; non-steroidal anti-inflammatory drug (NSAID) prescribing to people aged ≥75 without gastroprotection; NSAID prescribing to people prescribed aspirin/clopidogrel without gastroprotection; NSAID prescribing to people prescribed an ACE inhibitor/angiotensin receptor blocker and a diuretic; NSAID prescription to people prescribed an oral anticoagulant without gastroprotection; aspirin/clopidogrel prescription to people prescribed an oral anticoagulant without gastroprotection). The primary analysis will use multilevel modelling to account for repeated measurement of outcomes in patients clustered within practices. The study was reviewed and approved by the NHS Tayside Committee on Medical Research Ethics B (11/ES/0001). The study will be disseminated via a final report to the funder with a publicly available research summary, and peer reviewed publications

Association is not causation: treatment effects cannot be estimated from observational data in heart failure

Aims: Treatment ‘effects’ are often inferred from non-randomized and observational studies. These studies have inherent biases and limitations, which may make therapeutic inferences based on their results unreliable. We compared the conflicting findings of these studies to those of prospective randomized controlled trials (RCTs) in relation to pharmacological treatments for heart failure (HF). Methods and results: We searched Medline and Embase to identify studies of the association between non-randomized drug therapy and all-cause mortality in patients with HF until 31 December 2017. The treatments of interest were: angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, mineralocorticoid receptor antagonists (MRAs), statins, and digoxin. We compared the findings of these observational studies with those of relevant RCTs. We identified 92 publications, reporting 94 non-randomized studies, describing 158 estimates of the ‘effect’ of the six treatments of interest on all-cause mortality, i.e. some studies examined more than one treatment and/or HF phenotype. These six treatments had been tested in 25 RCTs. For example, two pivotal RCTs showed that MRAs reduced mortality in patients with HF with reduced ejection fraction. However, only one of 12 non-randomized studies found that MRAs were of benefit, with 10 finding a neutral effect, and one a harmful effect. Conclusion: This comprehensive comparison of studies of non-randomized data with the findings of RCTs in HF shows that it is not possible to make reliable therapeutic inferences from observational associations. While trials undoubtedly leave gaps in evidence and enrol selected participants, they clearly remain the best guide to the treatment of patients

How small is too small? A systematic review of center volume and outcome after cardiac transplantation

Background—The aim of this study was to assess the relationship between the volume of cardiac transplantation procedures performed in a center and the outcome after cardiac transplantation. Methods and Results—PubMed, Embase, and the Cochrane library were searched for articles on the volume–outcome relationship in cardiac transplantation. Ten studies were identified, and all adopted a different approach to data analysis and varied in adjustment for baseline characteristics. The number of patients in each study ranged from 798 to 14401, and observed 1-year mortality ranged from 12.6% to 34%. There was no association between the continuous variables of center volume and observed mortality. There was a weak association between the continuous variables of center volume and adjusted mortality up to 1 year and a stronger association at 5 years. When centers were grouped in volume categories, low-volume centers had the highest adjusted mortality, intermediate-volume centers had lower adjusted mortality, and high-volume centers had the lowest adjusted mortality but were not significantly better than intermediate-volume centers. Category limits were arbitrary and varied between studies. Conclusions—There is a relationship between center volume and mortality in heart transplantation. The existence of a minimum acceptable center volume or threshold is unproven. However, a level of 10 to 12 heart transplants per year corresponds to the upper limit of low-volume categories that may have relatively higher mortality. It is not known whether outcomes for patients treated in low-volume transplant centers would be improved by reorganizing centers to ensure volumes in excess of 10 to 12 heart transplants per year

Evidence for polar jets as precursors of polar plume formation

Observations from the Hinode/XRT telescope and STEREO/SECCHI/EUVI are utilized to study polar coronal jets and plumes. The study focuses on the temporal evolution of both structures and their relationship. The data sample, spanning April 7-8 2007, shows that over 90% of the 28 observed jet events are associated with polar plumes. EUV images (STEREO/SECCHI) show plume haze rising from the location of approximately 70% of the polar X-ray (Hinode/XRT) and EUV jets, with the plume haze appearing minutes to hours after the jet was observed. The remaining jets occurred in areas where plume material previously existed causing a brightness enhancement of the latter after the jet event. Short-lived, jet-like events and small transient bright points are seen (one at a time) at different locations within the base of pre-existing long-lived plumes. X-ray images also show instances (at least two events) of collimated-thin jets rapidly evolving into significantly wider plume-like structures that are followed by the delayed appearance of plume haze in the EUV. These observations provide evidence that X-ray jets are precursors of polar plumes, and in some cases cause brightenings of plumes. Possible mechanisms to explain the observed jet and plume relationship are discussed.Comment: 10 pages, 4 figures, accepted as APJ Lette

The Effects of Instructional Media on Learning Outcomes in Graduate Nursing and Physical Therapy Students at Angelo State University

Instructional media is the use of aids by an instructor to supplement student learning. Such aids have improved over the years in congruence with advances in technology. In this study, graduate physical therapy students (DPT) and graduate nursing students (GN) enrolled at Angelo State University were divided into two groups to examine the effects of supplemental instructional media on their learning experience. One group received instructional media resources in addition to PowerPoint lectures, while the control group received only the PowerPoint lectures. The intent was to determine if these additional resources contributed to improvements in the students’ grades as well as their level of engagement during a DPT and GN course. Students were separated into two GPA-matched groups with researchers blinded to participants’ group assignment. Learning outcomes were 3 quizzes, a written assignment, a test, and a survey regarding the instructional media interactions (administered to only the intervention group). Increased age of participants was negatively correlated with lack of engagement in the instructional media while all other outcomes were not found to be statistically significant. At this point, supplemental instructional media may not be necessary for students at the graduate level of healthcare education. However, as exposure to technology occurs at an earlier age, it may be necessary for teaching styles to adapt to accommodate technology influenced learning styles. Further studies should be conducted to determine if such adjustments will be necessary

Auxiliary field diffusion Monte Carlo calculations of light and medium-mass nuclei with local chiral interactions

Quantum Monte Carlo methods have recently been employed to study properties of nuclei and infinite matter using local chiral effective field theory interactions. In this work, we present a detailed description of the auxiliary field diffusion Monte Carlo algorithm for nuclei in combination with local chiral two- and three-nucleon interactions up to next-to-next-to-leading order. We show results for the binding energy, charge radius, charge form factor, and Coulomb sum rule in nuclei with $3\le A\le16$. Particular attention is devoted to the effect of different operator structures in the three-body force for different cutoffs. The outcomes suggest that local chiral interactions fit to few-body observables give a very good description of the ground-state properties of nuclei up to $^{16}$O, with the exception of one fit for the softer cutoff which predicts overbinding in larger nuclei.Comment: 23 pages, 10 figure