Evaluation of Ingenol mebutate efficacy for the treatment of actinic keratosis with Antera 3D camera

OBJECTIVE: Cumulative exposure of the skin to ultraviolet radiation promotes mutation in keratinocytes and their abnormal growth led to the formation of scaly lesions, called actinic keratoses (AKs). Its incidence is growing at an emerging rate, becoming a worldwide problem especially for occupational ultraviolet (UV) rays exposure. Detectable lesions are often associated with field changes, where the surrounding skin is altered and subclinical lesions may be present. Thus, a field-directed therapy, such as topical treatment, should be preferred for the prevention of invasive cancer development. A retrospective analysis was made, evaluating the efficacy of ingenol-mebutate gel, using a novel device the 3D in vivo optical skin Imaging (Antera 3D, Miravex, Ireland). PATIENTS AND METHODS: We included all patients with multiple non-hypertrophic Aks, to whom it was prescribed ingenol-mebutate gel, applied at the dosages of 0.015 for lesions in the scalp/face (for 3 consecutive days) and at the dosage of 0.05% for lesions in the trunk and/or extremities (for 2 consecutive days). RESULTS: A reduction of the lesions and of median hemoglobin levels, after a follow-up of 60 days, was observed in 100% of patients. CONCLUSIONS: Ingenol mebutate gel, the last topical molecule appeared in the Italian market showed its efficacy using Antera 3D also in terms of hemoglobin reduction. Therefore, this camera could be considered an useful tool for the identification of the area to be treated and for therapeutic follow-up

Steady state fluctuation relations for systems driven by an external random force

We experimentally study the fluctuations of the work done by an external Gaussian random force on two different stochastic systems coupled to a thermal bath: a colloidal particle in an optical trap and an atomic force microscopy cantilever. We determine the corresponding probability density functions for different random forcing amplitudes ranging from a small fraction to several times the amplitude of the thermal noise. In both systems for sufficiently weak forcing amplitudes the work fluctuations satisfy the usual steady state fluctuation theorem. As the forcing amplitude drives the system far from equilibrium, deviations of the fluctuation theorem increase monotonically. The deviations can be recasted to a single master curve which only depends on the kind of stochastic external force.Comment: 6 pages, submitted to EP

VHCF response of AM materials: A literature review

The present paper is an overview of the recent experimental results on the Very High Cycle Fatigue (VHCF) response of materials produced through additive manufacturing (AM) processes. At present, VHCF tests have been carried out on AlSi12, AlSi10Mg, and Ti6Al4V specimens produced through AM processes (SLM and EBM). The VHCF strength and the main findings provided in the literature are analyzed in the paper, focusing on the main factors that affect the fatigue response

Capillaroscopy in 2016 : new perspectives in systemic sclerosis

Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc. The best method to evaluate vascular injury is nailfold videocapillaroscopy, which detects peripheral capillary morphology, and classifies and scores the abnormalities into different patterns of microangiopathy. Microangiopathy appears to be the best evaluable predictor of the disease development and has been observed to precede the other symptoms by many years. Peripheral blood perfusion is also impaired in SSc, and there are different methods to assess it: laser Doppler and laser speckle techniques, thermography and other emerging techniques

Modelling size effects for static strength of brittle materials

The paper proposes a new model for the assessment of size effects affecting the fracture strength of brittle materials. The proposed model permits to accurately estimate the relation between the specimen strength, the initial defect size and to take into account the strength variation with respect to the tested volume. The proposed methodology is analytically defined and thereafter validated with the literature data obtained through tests on different types of brittle materials, and on specimens with increasing volume. A simple procedure for parameter estimation is also defined in the paper. The literature validation proves the effectiveness of the proposed methodology, with the resulting fitting models in well agreement with the experimental dataset and characterized by high values of coefficients of correlation, similar or larger than those obtained in the literature with different approaches

Investigation of influence of tab types on tensile strength of E-glass/epoxy fiber reinforced composite materials

Abstract Mechanical response of E-glass/epoxy fiber reinforced composite was investigated in tensile loading. Different types of tabs were considered in order to evaluate their effects on the tensile strength of material. Specifically, two types of molded tabs and five types of bonded tabs were considered in the study. The influence of different amount of gripping pressures on failure mode and on tensile strength of specimens was also considered in the analysis. The experimental results showed that the tabs configuration affected the tensile strength of the specimens. Starting from the experimental results, an appropriate testing methodology is proposed for E-glass/epoxy fiber reinforced composite specimens in order to reduce problems that may arise during the test and to optimize procedures for preparation of specimens

Effect of defect size on P-S-N curves in Very-High-Cycle Fatigue

It is well-known that internal defects play a key role in the Very-High-Cycle Fatigue (VHCF) response of metallic materials. VHCF failures generally nucleate from internal defects, whose size strongly affects the material strength and life. Therefore, S-N curves in the VHCF regime are defect size dependent and the scatter of fatigue data is significantly influenced by the statistical distribution of the defect size within the material. The present paper proposes an innovative approach for the statistical modeling of Probabilistic-S-N (P-S-N) curves in the VHCF regime. The proposed model considers conditional P-S-N curves that depend on a specific value of the initial defect size. From the statistical distribution of the initial defect size, marginal P-S-N curves are estimated and the effect of the risk-volume on the VHCF response is also modeled. Finally, the paper reports a numerical example that quantitatively illustrates the concepts of conditional and marginal P-S-N curves and that shows the effect of the risk-volume on the VHCF response

An innovative nondestructive technique for the local assessment of residual elastic properties in laminated composites

In this work, an innovative experimental methodology is presented for the assessment of damage severity in composites. The technique aims at determining the local variation of the elastic properties in the damaged region of a composite component. Based on the Impulse Excitation Technique (IET), the vibrational response of the inspected region is isolated by clamping its extremities through vacuum, thus allowing the assessment of local variations. Complementarily, a new analytical approach is derived for the assessment of the residual elastic properties of the damaged area from the measurement of the first resonant frequency. Validation of the proposed methodology is performed on two glass-fibre woven fabric composites, damaged by impact. The material properties of the damaged zone determined through the proposed technique are compared to the results of tensile tests performed on specimens cut from the impacted plates. In particular, the specimens are equipped with optic fibre in order to punctually measure the elastic parameters. Results show that the residual elastic properties assessed with the proposed technique are in very good agreement with those measured through the optic fibre, thus proving the effectiveness of the methodology