Phase transformations in mechanically alloyed Al-Cu-Cr powders

Mechanical alloying was used to form a decagonal phase in the Al-Cu-Cr system. Elemental powders of Al67Cu20Cr13, Al75Cu10Cr15, Al65Cu24Cr11, Al69Cu21Cr10 and Al78Cu10Cr12 compositions (in at. %) were mechanically alloyed in a planetary ball mill. Annealing in the temperature range of 500 to 550 0C results in the formation of binary and ternary compounds including the decagonal quasicrystalline phase that was found to be stable at least up to 800 0C and was present in various amounts in all investigated alloys. No icosahedral quasicrystalline phase was found in the samples. The maximum content (95 vol. %) of decagonal quasicrystalline phase was observed for Al69Cu21Cr10 compound annealed at 635 0С. Further increase in the annealing temperature results in the quasicrystalline phase transformation into ψ-Al65Cu25Cr10 phase, which is an approximant phase to icosahedral quasicrystal

Pionic Degrees of Freedom in Atomic Nuclei and Quasielastic Knockout of Pions by High-Energy Electrons

The nonlinear model of pionic condensate in nuclei by G. Preparata can be efficiently verified by investigation of the quasielastic knockout process of pions out of nuclei by high energy electrons. First, a momentum distribution (MD) of the collective pions has a bright maximum at q=0.3 Gev.Second the excitation spectrum of a recoil nucleus is concentrated at low energies E lesser than 1MeV. The results for the pion knockout from mesonic clouds of individual nucleons are absolutely different. The latter results are presented both for pion and rho-meson clouds localized on nucleons.Comment: 13 pages, 3 figure

Mechanisms of Development of Heart Failure in Chronic Kidney Disease

The study of scientific data over the past 5 years has shown that cardiorenal syndrome, which has a complex and multifactorial pathophysiology, is a clinical problem. Modern pharmacological methods of treatment are effective, but insufficient to satisfactorily influence or mitigate the progression of cardiorenal syndrome, therefore, the discovery of new drugs and new therapeutic strategies for cardiorenal syndrome is a high priority tas

Microscopics of meson degrees of freedom in nucleons and mesons in nuclei - what can be seen in the process of quasielastic knockout of mesons by high-energy electrons

Developed earlier concept of quasielastic knock out of pions from nucleons by high-energy electrons is propounded as a tool for checking microscopical model ($^3P_0$ - fluctuation) for decay of N to different channels $\pi+B$ and Preparata model of nucleus structure.Comment: 6 pages, 5 figures, Talk given at 16 Baldin Symposium in June 200

Аллерген-ассоциированные молекулярные паттерны: новое слово в современной аллергологии

Over the last decade the role of innate immunity has been known to be crucial for the activation of adaptive immune system. The main triggers that upregulate reactions of innate immunity are small exogenous molecules with conserved motifs, molecular patterns. The article discusses a variety of possible roles of molecular patterns in the immune mechanisms, including the participation of Allergen Associated Molecular Patterns (AAMPs) in allergic processes.В последнее десятилетие ни у кого не вызывает сомнения факт важности вовлечения в формирование адаптивного иммунного ответа компонентов врожденной иммунной системы. Основным триггером, вызывающим активацию врожденного иммунитета, являются молекулярные паттерны. В статье рассмотрены вопросы, касающиеся роли паттернов в механизмах иммунитета, а также освещены новые данные об аллерген-ассоциированных молекулярных паттернах

Piezo-Responsive Hydrogen-Bonded Frameworks Based on Vanillin-Barbiturate Conjugates

A concept of piezo-responsive hydrogen-bonded π-π-stacked organic frameworks made from Knoevenagel-condensed vanillin–barbiturate conjugates was proposed. Replacement of the substituent at the ether oxygen atom of the vanillin moiety from methyl (compound 3a) to ethyl (compound 3b) changed the appearance of the products from rigid rods to porous structures according to optical microscopy and scanning electron microscopy (SEM), and led to a decrease in the degree of crystallinity of corresponding powders according to X-ray diffractometry (XRD). Quantum chemical calculations of possible dimer models of vanillin–barbiturate conjugates using density functional theory (DFT) revealed that π-π stacking between aryl rings of the vanillin moiety stabilized the dimer to a greater extent than hydrogen bonding between carbonyl oxygen atoms and amide hydrogen atoms. According to piezoresponse force microscopy (PFM), there was a notable decrease in the vertical piezo-coefficient upon transition from rigid rods of compound 3a to irregular-shaped aggregates of compound 3b (average values of d33 coefficient corresponded to 2.74 ± 0.54 pm/V and 0.57 ± 0.11 pm/V), which is comparable to that of lithium niobate (d33 coefficient was 7 pm/V). © 2022 by the authors.2.1.06.03, 20211572; Russian Foundation for Basic Research, РФФИ: 20-53-00043-Bel_a; Ministry of Science and Technology, Taiwan, MOST: 19-52-06004 MNTI_a; Ural Federal University, UrFU: 2968; Ministry of Science and Higher Education of the Russian Federation: 075-15-2021-677The work was supported by the Russian Foundation for Basic Research (RFBR, project no. 20-53-00043-Bel_a) and the PFM measurements were done under RFBR and MOST project no. 19-52-06004 MNTI_a. The equipment of the Ural Center for Shared Use “Modern nanotechnology” Ural Federal University (Reg. No. 2968), which is supported by the Ministry of Science and Higher Education RF (project No. 075-15-2021-677), was used. T.V.S. acknowledges the support from the State Program of Scientific Researchers of Belarus (research issue 2.1.06.03, state registration number: 20211572)

Remote heart rate monitoring - Assessment of the Facereader rPPg by Noldus

Remote photoplethysmography (rPPG) allows contactless monitoring of human cardiac activity through a video camera. In this study, we assessed the accuracy and precision for heart rate measurements of the only consumer product available on the market, namely the Facereader™ rPPG by Noldus, with respect to a gold standard electrocardiograph. Twenty-four healthy participants were asked to sit in front of a computer screen and alternate two periods of rest with two stress tests (i.e. Go/No-Go task), while their heart rate was simultaneously acquired for 20 minutes using the ECG criterion measure and the Facereader™ rPPG. Results show that the Facereader™ rPPG tends to overestimate lower heart rates and underestimate higher heart rates compared to the ECG. The Facereader™ rPPG revealed a mean bias of 9.8 bpm, the 95% limits of agreement (LoA) ranged from almost -30 up to +50 bpm. These results suggest that whilst the rPPG Facereader™ technology has potential for contactless heart rate monitoring, its predictions are inaccurate for higher heart rates, with unacceptable precision across the entire range, rendering its estimates unreliable for monitoring individuals

PRODUCTION, PROPERTIES AND APPLICATION OF SACCHAROMYCES CEREVISIAE VGSH-2 INULINASE

Summary. Experimental data on an acid and thermal inactivation of a high refined inulinase (2,1-β-D- fructanfructanohydrolase, KF 3.2.17), produced by the race of Saccharomyces cerevisiae VGSh-2 yeast are presented. The strain of S. cerevisiae VGSh-2 was produced by the method of the induced mutagenesis and deposited to the collection of pure cultures of the chair of biochemistry and biotechnology of Voronezh state university of engineering technologies. The cells of source culture (S. cerevisiae XII) were affected step-by-step by the ultra-violet radiation (UFR) and UFR in a complex with a chemical mutagen (etilenimine). The culture was grown up by the method of liquid-phase deep cultivation on a constant nutrient medium. Refining conditions for inulinase are sorted out. Activity of enzyme dependence on physical and chemical factors (рН and temperature) is obtained and numerical values of the main kinetic constants – Km and Vmax are determined. The structure of enzyme molecule is studied by an infrared-spectroscopy method: the type and relative quantity of elements of secondary structure of protein are defined. Substrate binding groups of the active center of an inulinase are found. The comparative analysis of the ability to hydrolysis of inulin in several enzyme preparations from Jerusalem artichoke and to the subsequent their fermentation by the VGSh-2 and XI S. cerevisiae yeasts is carried out. Optimum conditions of enzyme hydrolysis of inulin are selected. Research of the fermentation process of starchcontaining raw materials by yeasts of VGSh-2 and XI races is done. It is established that the using of VGSh-2 S. cerevisiae yeast for a grain wort and the Jerusalem artichoke fermentation, allows to increase an extraction of ethyl alcohol comparing to control race, to improve its quality characteristics, and also allows to predict the using of new race in the food industry for production ethanol from grain raw materials and a fermentation of inulin containing raw materials