(2E,4E)-1-(6-Chloro-2-methyl-4-phenyl-3-quinol­yl)-5-phenyl­penta-2,4-dien-1-one

In the title compound, C27H20ClNO, the quinoline ring forms a dihedral angle of 62.53 (5)° with the substituent benzene ring. In the crystal, inter­molecular C—H⋯Cl inter­actions link the mol­ecules into chains along the b axis. Inter­molecular C—H⋯N and C—H⋯O hydrogen bonds further consolidate the structure into a three-dimensional network. The unit cell contains four solvent-accessible voids, each with a volume of 35 Å3, but no significant electron density was found in them

1-(6-Chloro-2-methyl-4-phenyl­quinolin-3-yl)-3-(3-methoxy­phen­yl)prop-2-en-1-one

In the title compound, C26H20ClNO2, the quinoline ring system is approximately planar with a maximum deviation of 0.028 (2) Å and forms a dihedral angle of 73.84 (5)° with the phenyl ring. Two neighbouring mol­ecules are arranged into a centrosymmetric dimer through a pair of inter­molecular C—H⋯Cl inter­actions. A pair of inter­molecular C—H⋯O hydrogen bonds link two methoxy­phenyl groups into another centrosymmetric dimer, generating an R 2 2(8) ring motif. The structure is further stabilized by C—H⋯π inter­actions

(E)-1-(6-Chloro-2-methyl-4-phenyl-3-quinol­yl)-3-(2-methoxy­phen­yl)prop-2-en-1-one

In the title compound, C26H20ClNO2, the quinoline ring system and the methoxy­phenyl ring form dihedral angles of 69.97 (6) and 22.10 (10)°, respectively, with the propenone linkage. The 4-phenyl ring substituent on the quinoline ring system is oriented at a dihedral angle of 66.47 (3)°. In the crystal, mol­ecules exist as C—H⋯O hydrogen-bonded dimers. The structure is further stabilized by C—H⋯π inter­actions

3-Acetyl-6-chloro-2-methyl-4-phenyl­quinolinium perchlorate

In the title mol­ecular salt, C18H15ClNO+·ClO4 −, the quinolin­ium ring system is approximately planar, with a maximum deviation of 0.027 (1) Å. The dihedral angle formed between the mean planes of the quinolinium ring system and the benzene ring is 78.46 (3)°. In the crystal structure, inter­molecular N—H⋯O and C—H⋯O hydrogen bonds link the cations and anions into a three-dimensional network. The crystal structure is further consolidated by C—H⋯π inter­actions

N-[(2-Chloro-3-quinol­yl)meth­yl]-4-fluoro­aniline

In the title compound, C16H12ClFN2, the dihedral angle between the quinoline ring system and the flourophenyl ring is 86.70 (4)°. In the crystal, mol­ecules are linked into chains along the a axis by N—H⋯N hydrogen bonds. In addition, C—H⋯π inter­actions involving the two benzene rings are observed

(E)-1-(2-Methyl-4-phenyl­quinolin-3-yl)-3-phenyl­prop-2-en-1-one

In the title compound, C25H19NO, the quinoline ring system is approximately planar, with a maximum deviation of 0.32 (1) Å, and forms dihedral angles of 80.74 (3) and 81.71 (4)° with the two phenyl rings. In the crystal. mol­ecules are stacked along the b axis by way of a C—H⋯π inter­action and a weak π–π inter­action between the pyridine and phenyl rings with a centroid–centroid distance of 3.6924 (5) Å

Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice

OBJECTIVE—NOD mice model human type 1 diabetes and are used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. However, costimulation blockade–based tolerance protocols have failed in prolonging islet allograft survival in NOD mice

Mechanism of cellular rejection in transplantation

The explosion of new discoveries in the field of immunology has provided new insights into mechanisms that promote an immune response directed against a transplanted organ. Central to the allograft response are T lymphocytes. This review summarizes the current literature on allorecognition, costimulation, memory T cells, T cell migration, and their role in both acute and chronic graft destruction. An in depth understanding of the cellular mechanisms that result in both acute and chronic allograft rejection will provide new strategies and targeted therapeutics capable of inducing long-lasting, allograft-specific tolerance